Caril J. March

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Jana L. Jackson

Emory University

J Wignall

Vita-Salute San Raffaele University

Michael B. Widmer

Mercy Health

C. E. Grubin

University of Washington

David Cosman

IDEX Corporation (United States)

Della Friend

Fred Hutch Cancer Center

A Alpert

Research & Development Corporation

David L. Urdal

Dendreon (United States)

H. Robson MacDonald

University of Toronto

Susan M. Call

Massachusetts Institute of Technology

Cooperative Institutions

IDEX Corporation (United States)

Amgen (United States)

University of Washington

Seattle University

Research & Development Corporation

Harvard University

Fred Hutch Cancer Center

Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa

Dendreon (United States)

University of Florida

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cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

Science (1988)

John E. Sims Caril J. March David Cosman Michael B. Widmer H. Robson MacDonald

Interleukin-1 alpha and -1 beta (IL-1α and IL-1β) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1α and IL-1β in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long.

Expression cloning

Interleukin-4 receptor

Immunoglobulin superfamily

Cloning (programming)

Immunoglobulin domain

10.1126/science.2969618

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Citations (896)