F. Turrini

University of Turin

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Paolo Arese

University of Turin

Federico Bussolino

Candiolo Cancer Institute

Franca Mannu

University of Sassari

Gianpiero Pescarmona

University of Turin

Amalia Bosìa

University of Turin

Maria Domenica Cappellini

University of Milan

Lucia De Franceschi

University of Verona

Giuliana Giribaldi

University of Turin

H. Ginsburg

Hebrew University of Jerusalem

Achille Iolascon

University of Naples Federico II

Cooperative Institutions

University of Turin

University of Sassari

Istituti di Ricovero e Cura a Carattere Scientifico

University of Milan

Azienda Ospedaliero Universitaria San Giovanni Battista

University of Verona

Ospedale Regina Margherita

Ospedale Maggiore

Azienda Ospedaliera Citta' della Salute e della Scienza di Torino

Fondazione Ricerca Molinette

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Analysis of membrane proteins from fractioned red cell by 2-D electrophoresis: comparison between normal and sickle red cells.

Lucia De Franceschi Andrea Biondani Franco Carta Paola Roncada Roberto Corrocher

Red Cell

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Citations (0)

Role of hemichrome binding to erythrocyte membrane in the generation of band-3 alterations in beta-thalassemia intermedia erythrocytes

Blood (1995)

Franca Mannu Paolo Arese Maria Domenica Cappellini G. Fiorelli Marina Cappadoro

Band 3

Heinz body

10.1182/blood.v86.5.2014.bloodjournal8652014

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Citations (107)

Platelet activating factor induces dopamine release in PC-12 cell line

AJP Cell Physiology (1988)

Federico Bussolino F. Tessari F. Turrini P. Braquet Giovanni Camussi

The ability of platelet activating factor (PAF) to stimulate dopamine release and modify calcium homeostasis in PC-12 cell line was studied. PAF-induced dopamine release is related to its molecular form, with only the R-form steric configuration [(R)PAF], but not its S-form or its 2-lyso derivative, effective at being active. In addition, PAF acts at very low concentrations in a dose-dependent manner (0.1-30 nM). Preincubation with PAF receptor antagonists (CV-3988 and BN52021) as well as the specific desensitization of PC-12 cells to (R)PAF abolish the (R)PAF-induced dopamine release. Several lines of evidence suggest that dopamine release is dependent on a (R)PAF-induced calcium influx and efflux modulation. Dopamine release by PC-12 cells challenged with (R)PAF is associated with a rapid 45Ca influx and efflux and a rise in cytoplasmic calcium concentrations ([Ca2+]i) evaluated by using the calcium indicators fura-2 and quin2. At 30 nM (R)PAF, the absence of extracellular calcium inhibits the dopamine release but not the rise of [Ca2+]i from the internal stores, suggesting the importance of calcium influx in (R)PAF-induced dopamine release. PAF, which has been reported to be synthesized by stimulated neuronal cells (J. Biol. Chem. 261: 16502-16508, 1986) may thus have a physiological modulatory role on cells with neurosecretory properties.

Platelet-activating factor

10.1152/ajpcell.1988.255.4.c559

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Citations (31)

Stimulation of the Na+/H+ exchanger in human endothelial cells activated by granulocyte- and granulocyte-macrophage-colony-stimulating factor

Journal of Biological Chemistry (1989)

Federico Bussolino Jie‐Mei Wang F. Turrini Daniela Alessi Dario Ghigo

It has been shown that human endothelial cells (HEC)are stimulated to migrate and proliferate by granulocyte (G)and granulocyte-macrophage (GM)-colonystimulating factor (CSF) (Bussolino, F.,

Colony-stimulating factor

10.1016/s0021-9258(18)51460-5

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Citations (66)

Phagocytosis of Plasmodium falciparum-infected human red blood cells by human monocytes: involvement of immune and nonimmune determinants and dependence on parasite developmental stage

Blood (1992)

F. Turrini H. Ginsburg Federico Bussolino Gianpiero Pescarmona MV Serra

Phagocyte

Monocyte

Antibody opsonization

10.1182/blood.v80.3.801.801

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Citations (109)

Prevention of Acute Renal Failure (ARF) by Diuretics and Hydration

Springer eBooks (1987)

R. Faedda Andrea Satta G. F. Branca F. Turrini E Bartoli

Renal ischemia

Oliguria

10.1007/978-1-4613-2067-8_88

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Erythrophagocytosis in malaria: Host defence or menace to the macrophage?

Parasitology Today (1991)

Paolo Arese F. Turrini H. Ginsburg

Plasmodium (life cycle)

10.1016/0169-4758(91)90082-y

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Citations (38)

Platelet-activating factor enhances complement-dependent phagocytosis of diamide-treated erythrocytes by human monocytes through activation of protein kinase C and phosphorylation of complement receptor type one (CR1)

Journal of Biological Chemistry (1989)

Federico Bussolino Evelyne Fischer F. Turrini M Kazatchkine Paolo Arese

Oligomerization of band 3 protein has been recently indicated as an early event in senescent or damaged red cell membrane followed by specific deposition of anti-band 3 antibodies and binding of complement C3 fragments. The band 3-anti-band 3-C3b complex is recognized by homologous monocytes, and phagocytosis ensues. This study shows that recognition of the anti-band 3-C3b complex by the monocyte C3b receptor type one (CR1) plays a crucial role in the process of removal of damaged red cells. Indeed, blocking of monocyte CR1 with an anti-CR1 monoclonal antibody abrogated phagocytosis of diamide-treated red cells. Platelet-activating factor (PAF) is a phospholipid mediator involved in inflammatory processes. Nanomolar (R)-PAF enhanced the CR1-dependent phagocytosis of diamide-treated human red cell and of sheep red cells coated with C3b, induced the fast translocation of protein kinase C to monocyte membrane compartment, and stimulated the phosphorylation of monocyte CR1. The biologically inert lyso-PAF and the enantiomer (S)-PAF were inactive. PAF receptor antagonists and inhibitors of protein kinase C blocked the enhancement of phagocytosis induced by PAF. Protein kinase C translocation, phosphorylation of CR1, and stimulation of this receptor to an active state capable of mediating phagocytosis represent a novel pathway by which PAF interferes with red cell homeostasis and possibly modulates inflammatory reactions and host mechanisms against infections.

Complement

10.1016/s0021-9258(20)88244-1

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Citations (40)

Helicobacter infection and cirrhosis in hepatitis C virus carriage: is it an innocent bystander or a troublemaker?

Medical Hypotheses (2000)

Antonio Ponzetto Rinaldo Pellicano Nicola Leone Miguel Angel Cutufia F. Turrini

Helicobacter

Pathogenesis

10.1054/mehy.1999.0987

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Citations (97)

Pathophysiology of favism.

PubMed (1989)

Paolo Arese L Mannuzzu F. Turrini

Haemolytic crises occurring in G6PD-deficient individuals after ingestion of fava beans (favism) are much less frequent than in the past. However, favism is a unique natural model of oxidant damage in vivo, useful for the study of senescent or damaged red blood cells (RBC) clearance from circulation. The following aspects have been considered: 1. Pathophysiology of favism, including incidence, salient features, and sequence of events. 2. RBC alterations during the haemolytic crisis: biochemical, rheological and morphological alterations occurring in RBC isolated at different stages of the crisis. 3. Toxic substances of Vicia faba and their mechanism of action: treatment of G6PD-deficient RBC with divicine or isouramil (redox substances present in fava beans) provokes the same changes as observed during favism. 4. Intravascular vs. extravascular haemolysis: extravascular (i.e. phagocytic) removal of damages RBC seems predominant in favism. 5. The signal for RBC removal: in analogy with a recent model for recognition and removal of oxidant-stressed or senescent RBC, we propose removal of fava bean damaged RBC be mediated by apposition of antiband 3 antibodies and complement C3 fragments, recognized as non-self recognition signal by monocytes and macrophages.

Haemolysis

Pathophysiology

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Citations (19)