Some mild, moderate, and moderately severe-hearing impaired children have poor language and educational problems despite comparatively good hearing. We studied 30 mild, moderate, and moderately severe hearing-impaired children cared for at Showa University and Jiseikai Hospitals. Their ages ranged from 3 to 14 years and average hearing from 35.0 dB HL to 68.8 dB HL. Our findings were as follows: (1) The average age of suspected hearing problem onset was 2 years 10 months. On the average, delayed diagnosis was made at 4 years 2 months and children were fitted with hearing aids at 5 years 3 months. (2) Over 25% them wore hearing aids infrequently. (3) Language delay was observed in 14 of 24 children examined using the WISC-III test. Many wore hearing aids infrequently and exhibited inadequate oral communication in Japanese due, for example, to deaf parents or children educated overseas. (4) According to a questionnaire, many mothers usually talked to the children aware of their hearing condition. But almost mothers of children with delayed development could not teach children if they couldn't hear, and only repeated same words for children's clarification, e.g., "Pardon?". It is important to detect hearing impairment in children as early as possible. Guidance by specialists and communication training are very important, especially for children who are mild, moderate, and moderately severe hearing-impaired.
われわれは, 両側側頭葉前方下部に病変を有し, 比較的選択的に意味記憶の障害をきたした症例 R. N. を経験した。症例 R. N. は神経学的には異常を示さず神経心理学的には Korsakoff 症状群と超皮質性感覚失語を呈していたが, 大きな特徴は, 洗顔クリームの代わりに歯磨き粉を使ったりするように物品の使用に障害を示したことである。物品使用の障害は失語では説明できない現象であり, また, 物品使用の検査では, 症例 R. N. は観念運動/観念失行患者群および健忘症状群とは異なった反応パターンを示し, 症例 R. N.の物品使用の誤りは使用法の忘却に起因すると考えられるものであった。この現象は, 超皮質性感覚失語も考慮すると, 意味記憶の障害の反映であると考察された。症例 R. N.の意味記憶の障害には様態特異性と上位概念の保持は必ずしも認められるとは言い難かったが, 範疇特異性が一応認められた。
A bacteriological study on otorrhea in 152 cases of acute purulent otitis media in children was carried out. Forty strains of Haemophilus influenzae (26%), 35 strains of Streptococcus pneumoniae (23%), 33 strains of Staphylococcus epidermidis (22%), 32 strains of Staphylococcus aureus (21%), 3 strains of Streptococcus pyogenes (Group A) (2%) and other 8 strains (5%) were isolated.Reviewing the annual data of otorrhea isolates from 1963 to 1980, Staphylococcus aureus and Streptococcus pyogenes (Group A) of gram-positive cocci decreased, while Haemophilus influenzae of gram-negative bacIlli remarkably increased. Increase of Haemophilus influenzae is caused by the technical improvement of isolating the said bacterium and also actual increase of otitis media by the pathagen of Haemophilus influenzae.One-forth of the children with otorrhea showed the hard-curable process such as recurrenceor recovery-delaying. Haemophilus influenzae was isolated in a high rate (46.9%) from otor-rhea of the children with hard-curable otitis media.
ACTH and cAMP stimulate steroidogenesis and the mitochondrial electron transport system for steroid hydroxylation in cultured mouse adrenal cortex tumor cells. During this stimulation, the biosynthesis of adrenodoxin, a non-heme iron protein which is one of the electron transport enzymes, was examined. 14C-labeled adrenodoxin was isolated by employing a purified rabbit antibody to bovine adrenodoxin. The antibody-adrenodoxin precipitates were further purified by acrylamide gel electrophoresis. It was observed that the biosynthesis of adrenodoxin was stimulated in response to ACTH induction and that this stimulation was completely inhibited with cycloheximide and partially inhibited with chloramphenicol. As a result, it was concluded that adrenodoxin requires both mitochondrial and cytosol ribosomal activities for its synthesis and integration into adrenal mitochrondria.
Journal Article Effects of Antibiotics on Adaptive Formation of Mitochondria in Yeast Get access Kimiko ASANO Kimiko ASANO The Laboratory of Molecular Genetics, Osaka University School of MedicineOsaka Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 72, Issue 3, September 1972, Pages 737–747, https://doi.org/10.1093/oxfordjournals.jbchem.a129952 Published: 01 September 1972 Article history Received: 03 April 1972 Published: 01 September 1972
Acute otitis media, generally complicated by conductive hearing loss, sometimes shows raised bone conduction thresholds. Five patients with acute otitis media with mixed hearing loss and much otorrhea were reported. The chief complaints were otalgia in 3 patients, hearing loss in 4, ear fullness in 1 and tinnitus in 1. Four patients had moderate hearing loss. At the first examination, the tympanic membrane showed swelling and injection, while 2 showed bullous myringitis, with swelling of the tympanic mucosa and a yellowish serous discharge following myringotomy. Positive mastoidal CT of all patients without acute inflammatory symptoms in the external ear suggest the complication of acute mastoiditis. After treatment with antibiotics and myingotomy for all patients, steroidal administration for 4, and tympanostomy tube insertion for 3, the hearing levels of 4 patients improved. Sensorineural hearing loss (51.3 dB) remains in 1 patient with sever hearing loss at the first examination. It is important to determine the hearing level for patients with acute otitis media, especially if it is complicated by hearing difficulties.
