Hawai'i experiences some of the highest rates of houselessness per capita in the country. COVID-19 has exacerbated these disparities and made it difficult for these individuals to seek medical care. Hawai'i's Houseless Outreach in Medical Education (HOME) clinic is the largest student run free clinic in the state, which provides medical services to this patient population. This article reports the demographics, medical needs, and services provided to patients of Hawai'i's HOME clinic during the era of COVID-19. From September 2020 to 2021, the HOME clinic saw 1198 unique visits with 526 distinct patients. The most common chief complaints included wound care (42.4%), pain (26.9%), and skin complaints (15.7%). A large portion of the population suffered from comorbidities including elevated blood pressure (66%), a formal reported history of hypertension (30.6%), diabetes (11.6%), and psychiatric concerns including schizophrenia (5.2%) and generalized anxiety (5.1%). Additionally, a large portion of patients (57.2%) were substance users including 17.8% of patients endorsing use of alcohol, 48.5% tobacco and 12.5% marijuana. The most common services provided were dispensation of medication (58.7%), wound cleaning/dressing changes (30.7%), and alcohol or other drug cessation counseling (25.2%). This study emphasizes that the houseless are a diverse population with complex, evolving medical needs and a high prevalence of chronic diseases and comorbidities.
Introduction:The World Health Organization (WHO) recently reported that depression is a major cause of disability worldwide, with more than 320 million people affected globally (World Health Organization, 2017).Aim of the work: is to describe sociodemographic characteristics in a sample of patients diagnosed with major depressive disorder.Patients and methods: 51 Patients were referred from the outpatient psychiatric clinics of Minia governorate, Minia University hospitals outpatient psychiatric clinic, Minia psychiatric hospital and the study was held in Minia university hospitals during the period from December 1, 2018 to October 1, 2019.Results: the mean age of the sample was 35.44 ± 10.402 years, ranging from 18 to 55 years.Nearly half of the participants were females (55.6%).More than a half of them (57.8%) were married, while (31.3%) were single.Rural residents (53.3%) were more common than urban (46.7 %).The most common educational level was high-education (31.1%) followed by technical education (26.7%).Full time employees were (53.3%) followed by unemployed and not looking for work (31.1%).The majority of patients (73.3%) reported significant environmental stressor or precipitant prior to the onset of depression.Conclusion: depression is more common in third decade of life, more common in females more than males and highly-related to significant life stressors.
The aim of this study was to evaluate whether the blockade of renin-angiotensin system (RAS), achieved by angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs), could affect the plasma lipid profile in chronic kidney disease (CKD) patients. Ninety-four hypertensive patients with CKD (stage 3-5) were enrolled. Forty-nine patients were treated with either ACEIs or ARBs daily for 6 months, and forty-five patients were treated with other antihypertensive agents (calcium channel blockers (amlodipine), b blockers, diuretics) as positive control group. Creatinine, estimated glomerular filtration rate (eGFR), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglyceride (TG) levels measurements were performed before and after the six-month treatment. An improvement in serum lipids levels in hypertensive patients with CKD resulted from RAS blocked therapy and other antihypertensive agents. Both treatment groups significantly decreased total cholesterol (TC), by 7.77% in ACEIs/ARBs group (p≤0.01) and 6.42% in other antihypertensive group (p≤0.05). In CKD patients treated with ACEIs/ARBs, levels of TG (3.29%), and LDL-C (3.15%) dropped more than with other antihypertensive medications (2.12%, and 1.19% respectively). RAS blocked therapy significantly increased HDL-C levels in CKD patients by 5.94% (p≤0.05). The results indicate that RAS blockade therapy with ACEIs or ARB positively affects lipid profile, which may improve the cardiovascular risks caused by CKD.
Nous etudions un systeme semi-lineaire des equations aux derivees partielles issu de la physique du laser-plasma. Ce systeme est faiblement amorti, partiellement dissipatif et decrit l'interaction resonnante de trois ondes non lineaires. Dans la premiere partie, on demontre des resultats d'existence, d'unicite et de regularite de la solution. On demontre aussi l'existence d'un attractor universel et d'une variete inertielle et on estime les dimensions correspondantes. Les resultats precedents sont obtenus dans un domaine fini. Finalement, des resultats d'existence, d'unicite et de regularite pour le meme probleme sont obtenus dans un domaine infini
Chronic kidney disease (CKD) is associated with high morbidity and increased cardiovascular mortality. Chronic inflammation was found to be correlated with cardiovascular disease (CVD) in CKD population. High-sensitivity C-reactive protein (hs-CRP), is one of biomarkers of subclinical inflammation, and widely used as an independent predictor of cardiovascular risk. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were introduced as potential markers for evaluation of inflammation in several diseases. However, there are a few studies in CKD patients. We aimed to evaluate the relationship of NLR and PLR with hs-CRP levels in Syrian patients with CKD. The study included 100 CKD patients in stages 3 to 5 seen at Tishreen University Hospital, and 22 subjects served as control. CKD patients were divided into two groups, according to the presence or absence of inflammation, based on the high-sensitivity C-reactive protein (hs-CRP) cut off value of 3 mg/l. Blood samples were collected for blood count and hs-CRP levels determination. hs-CRP concentration was measured by immunoturbidimetry assay kit. NLR and PLR were calculated based on the absolute number of neutrophils, lymphocytes and platelets. We used the SPSS 25.0 program for the statistical analysis. Probability (P) value<0.05 was considered statistically significant. NLR as well as PLR and hs-CRP levels were significantly higher in all CKD groups compared to control subjects (p<0.05, for all). NLR and PLR values were significantly different between CKD groups with and without inflammation (for both, p<0.001). Both NLR and PLR were positively correlated with hs-CRP (r=0.50, p<0.001 for NLR; r=0.43, p<0.001 for PLR) in CKD patients. The best cutoff point for NLR to detect inflammation was ≥3.06, with 70% sensitivity and 81.1% specificity. For PLR, the cut off was ≥144.78, with 59% sensitivity and 73% specificity. There was no significant difference between the area under the NLR and PLR curve (0.77 vs. 0.70, p=0.19) for this population. Our findings suggests that NLR and PLR are available, simple and less expensive methods that could be used as markers of inflammation in CKD patients instead of hs-CRP.