Halıl Yaman

Mersin Üniversitesi

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EÖ

Emin Özgür Akgül

Memorial Ankara Hospital

EÇ

Erdinç Çakır

Turkish Armed Forces

TÇ

Tuncer Çaycı

Turkish Armed Forces

Yasemin Gülcan Kurt

Turkish Armed Forces

M. Erbil

Cukurova University

Mİ

Mahmut İlker Yılmaz

Gülhane Askerî Tıp Akademisi

Mehmet Ağıllı

University of Health Sciences Antigua

Selim Kılıç

GATA Haydarpaşa Eğitim Hastanesi

İA

İbrahim Aydın

Education Training And Research

TÇ

Turgay Çelik

Wake Forest University

Cooperative Institutions

Turkish Armed Forces

274

Gülhane Askerî Tıp Akademisi

237

Military Medical Academy

222

Sağlık Bilimleri Üniversitesi

129

Gazi University

Hacettepe University

Ankara University

Military Hospital

Memorial Ankara Hospital

University of Health Sciences Antigua

Author Statistics

Papers

Citation

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Experimental immunology The impact of oral dexamethasone on Toll-like receptor levels in neonatal rat intestine

Central European Journal of Immunology (2012)

Tarık Purtuloğlu Gökhan Aydemir Mehmet Saldır Abdülbaki Karaoğlu Galip Erdem

AMA Purtuloglu T, Aydemir G, Saldir M, et al. Experimental immunologyThe impact of oral dexamethasone on Toll-like receptor levels in neonatal rat intestine. Central European Journal of Immunology. 2012;37(4):303-306. doi:10.5114/ceji.2012.32715. APA Purtuloglu, T., Aydemir, G., Saldir, M., Karaoglu, A., Erdem, G., & Fidanci, K. et al. (2012). Experimental immunologyThe impact of oral dexamethasone on Toll-like receptor levels in neonatal rat intestine. Central European Journal of Immunology, 37(4), 303-306. https://doi.org/10.5114/ceji.2012.32715 Chicago Purtuloglu, Tarik, Gokhan Aydemir, Mehmet Saldir, Abdulbaki Karaoglu, Galip Erdem, Kursat M. Fidanci, and Oguzhan Babacan et al. 2012. "Experimental immunologyThe impact of oral dexamethasone on Toll-like receptor levels in neonatal rat intestine". Central European Journal of Immunology 37 (4): 303-306. doi:10.5114/ceji.2012.32715. Harvard Purtuloglu, T., Aydemir, G., Saldir, M., Karaoglu, A., Erdem, G., Fidanci, K., Babacan, O., Cekmez, F., Tunc, T., Yaman, H., and Sarici, S. (2012). Experimental immunologyThe impact of oral dexamethasone on Toll-like receptor levels in neonatal rat intestine. Central European Journal of Immunology, 37(4), pp.303-306. https://doi.org/10.5114/ceji.2012.32715 MLA Purtuloglu, Tarik et al. "Experimental immunologyThe impact of oral dexamethasone on Toll-like receptor levels in neonatal rat intestine." Central European Journal of Immunology, vol. 37, no. 4, 2012, pp. 303-306. doi:10.5114/ceji.2012.32715. Vancouver Purtuloglu T, Aydemir G, Saldir M, Karaoglu A, Erdem G, Fidanci K et al. Experimental immunologyThe impact of oral dexamethasone on Toll-like receptor levels in neonatal rat intestine. Central European Journal of Immunology. 2012;37(4):303-306. doi:10.5114/ceji.2012.32715.

10.5114/ceji.2012.32715

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Citations (0)

Toll-like receptor levels and caffeine responsiveness in rat pups during perinatal period

Regulatory Peptides (2013)

Turan Tunç Gökhan Aydemir Abdülbaki Karaoğlu Ferhat Çekmez Mustafa Kul

Bronchopulmonary Dysplasia

TLR9

10.1016/j.regpep.2012.12.016

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Citations (17)

The protective effect of melatonin and S-methylisothiourea treatments in nitrogen mustard induced lung toxicity in rats

Environmental Toxicology and Pharmacology (2013)

Enis Macit Hakan Yaren İbrahim Aydın Zeki Ilker Kunak Halıl Yaman

10.1016/j.etap.2013.10.001

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Citations (17)

Protective Effects of Melatonin and S-Methylisothiourea on Mechlorethamine Induced Nephrotoxicity

Journal of Surgical Research (2011)

Zeki Ilker Kunak Enis Macit Hakan Yaren Halıl Yaman Erdinç Çakır

Nephrotoxicity

10.1016/j.jss.2011.11.002

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Citations (24)

Beneficial Effects ofN-Acetylcysteine and Ebselen on Renal Ischemia/Reperfusion Injury

Renal Failure (2011)

Murat Kızılgün Yavuz Poyrazoğlu Yeşim Öztaş Halıl Yaman Erdinç Çakır

Introduction: It has been demonstrated that peroxynitrite accompanies acute renal ischemia and contributes to the pathophysiology of renal damage. Therefore, we aimed to investigate the roles of N-acetylcysteine (NAC), a well-known powerful antioxidant, and ebselen (E), a scavenger of peroxynitrite, on renal injury induced by renal ischemia/reperfusion injury (IRI) of rat kidney. Materials and methods: Forty male Sprague–Dawley rats were divided into five groups: sham, renal IRI, renal IRI+NAC, renal IRI+E, and renal IRI+NAC+E. IR injury was induced by 60 min of bilateral renal ischemia followed by 6 h of reperfusion. After reperfusion, kidneys and blood samples were obtained for histopathological and biochemical evaluations. Results: Renal IR resulted in increased malondialdehyde and nitrite/nitrate levels suggesting increased lipid peroxidation and peroxynitrite production and decreased superoxide dismutase and glutathione peroxidase activities. Both NAC and E alone significantly decreased malondialdehyde and nitrite/nitrate levels and increased superoxide dismutase and glutathione peroxidase activities. Additionally in the renal IRI+NAC+E group, all biochemical results were quite close to those of sham group. Histopathologically, the kidney injury in rats treated with combination of NAC and E was found significantly less than the other groups. Conclusions: Both NAC and E are able to ameliorate IRI of the kidney by decreasing oxidative and nitrosative stresses and increasing free radical scavenger properties. Additionally, combination of NAC and E prevents kidney damage more than when each drug is used alone, suggesting that scavenging peroxynitrite nearby antioxidant activity is important in preventing renal IRI.

Malondialdehyde

Renal ischemia

Ebselen

10.3109/0886022x.2011.574767

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Citations (41)

Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients

Journal of Hypertension (2006)

Turgay Çelik Atila Iyısoy Hürkan Kurşaklıoğlu Ejder Kardeşoğlu Selim Kılıç

Objectives To determine the effects of nebivolol on oxidative stress, insulin resistance, adiponectin and plasma soluble P-selectin levels in hypertensive patients in comparison with metoprolol. Material and methods Eighty newly diagnosed hypertensive patients in grade 1 hypertension according to the European Society of Hypertension and European Society of Cardiology guidelines were enrolled in this prospective, blinded, randomized study. Seventy-two patients completed the study. After baseline assessment, each patient was randomly allocated to a 5 mg daily dose of nebivolol (n = 37, 20 male) or a 100 mg daily dose of metoprolol (n = 35, 18 male) and treated for 6 months. Blood pressure, heart rate, oxidative stress (malonyldialdehyde), homeostasis model assessment: insulin resistance, adiponectin and plasma soluble P-selectin levels were measured before and after treatment. Results At the end of treatment, nebivolol and metoprolol significantly decreased blood pressure and heart rate, with a more pronounced bradycardic effect of metoprolol. Nebivolol, but not metoprolol, significantly lowered oxidative stress (P = 0.03), the insulin resistance index (P = 0.003) and plasma soluble P-selectin levels (P = 0.008), and increased adiponectin levels (P = 0.04). Conclusion Nebivolol, in contrast to metoprolol, improved oxidative stress, insulin sensitivity, decreased plasma soluble P-selectin and increased adiponectin levels in hypertensive patients. These beneficial effects of nebivolol may contribute to a reduction in cardiovascular risk in hypertensive patients.

Nebivolol

10.1097/01.hjh.0000209993.26057.de

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Citations (195)

Serum neutrophil gelatinase-associated lipocalin is associated with cardiovascular events in patients with chronic kidney disease

International Urology and Nephrology (2015)

Yalçın Solak Mahmut İlker Yılmaz Dimitrie Siriopol Mutlu Sağlam Hilmi Umut Ünal

Neutrophil gelatinase-associated lipocalin

Nephrology

10.1007/s11255-015-1136-4

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Citations (13)

Serum ischemia modified albumin levels in pregnancies with neural tube defects.

PubMed (2012)

İsmail Güzelmansur Yusuf Üstün Yaprak Engin Üstün Özlem Görüroğlu Öztürk Halıl Yaman

To evaluate ischemia-modified albumin (IMA) in women who had been pregnant with a child suffering from neural tube defect.Samples from 50 women who had been pregnant with an affected child (25 spina bifida, 25 anencephaly) and 25 controls matched for age, gestational age, and body mass index were studied. We measured serum IMA by enzyme-linked immunosorbent assay.Serum IMA was significantly higher in the study group compared to normal pregnancies (p < 0.05). The area under the receiver operating curve was 0.858 for IMA (95% CI, 0.769-0.947), whereas the optimal threshold value of IMA to discriminate between affected children and controls was 0.409 (sensitivity 88%, specificity 80%). The risk for increased IMA in mothers who have conceived a fetus with neural tube defect is 24.5 times higher than in the control group (rr = 24.5, 6.9-86.9, 95% CI) (p = 0.001).This study indicates that serum IMA in women who have conceived a fetus with neural tube defect is significantly higher than that in normal pregnant women.

Anencephaly

Neural tube defect

Ischemia-modified albumin

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Citations (2)

Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever

Clinical Chemistry and Laboratory Medicine (CCLM) (2009)

Yasemin Gülcan Kurt Tuncer Çaycı Pınar Öngürü Emin Özgür Akgül Halıl Yaman

Crimean-Congo hemorrhagic fever (CCHF) is a public health problem in many countries. Chitotriosidase (ChT) is an enzyme secreted by activated macrophages that catalyzes the hydrolysis of chitin and chitin-like substrates. The goal of this study was to assess the relationship between serum ChT activity and mortality.ChT activities on the first day of hospitalization were analyzed in serum from 46 patients with CCHF and 36 healthy controls. Serum ChT activities and other clinical and laboratory parameters for patients with non-fatal and fatal CCHF were compared.The median ChT activity was increased in all patients with CCHF [189.9 (134.8-246.6) nmol/mL/h]. The median ChT activity in the non-fatal CCHF group [220.2 (180.6-290.1) nmol/mL/h] was higher compared with the fatal CCHF group [29.2 (16.5-45.7) nmol/mL/h] (p<0.001). In univariate analysis, platelet count, lactate dehydrogenase (LDH), and activated partial thromboplastin time were associated with mortality.This is the first study investigating the association of serum ChT enzyme activity with mortality from CCHF. This study suggested that relatively low ChT enzyme activities may be a prognostic marker in patients with CCHF.

Crimean–Congo hemorrhagic fever

10.1515/cclm.2009.347

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Citations (11)

Elevated plasma asymmetric dimethylarginine level in acute myocardial infarction patients as a predictor of poor prognosis and angiographic impaired reperfusion

Atherosclerosis (2011)

Nihat Şen Mehmet Fatih Özlü Emin Özgür Akgül Selçuk Kanat Tuncer Çaycı

TIMI

Asymmetric dimethylarginine

10.1016/j.atherosclerosis.2011.06.021

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Citations (31)