Maria C. Jockers‐Scherübl

Charité - Universitätsmedizin Berlin

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Johannes Rentzsch

Medizinische Hochschule Brandenburg Theodor Fontane

Rainer Hellweg

Charité - Universitätsmedizin Berlin

Jürgen Gallinat

Universität Hamburg

Heidi Danker‐Hopfe

Freie Universität Berlin

Andres H. Neuhaus

Charité - Universitätsmedizin Berlin

Christiane Montag

Charité - Universitätsmedizin Berlin

Theresa Wolf

Charité - Universitätsmedizin Berlin

Undine E. Lang

University of Basel

F. Godemann

St. Joseph-Krankenhaus

Pavel Halkin

Brandenburg University of Applied Sciences

Cooperative Institutions

Charité - Universitätsmedizin Berlin

Freie Universität Berlin

Humboldt-Universität zu Berlin

Klinik und Poliklinik für Psychiatrie und Psychotherapie

Franklin University

Berlin Institute of Health at Charité - Universitätsmedizin Berlin

Ludwig-Maximilians-Universität München

University of Göttingen

Johannes Gutenberg University Mainz

LMU Klinikum

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Differential impact of heavy cannabis use on sensory gating in schizophrenic patients and otherwise healthy controls

Experimental Neurology (2007)

Johannes Rentzsch A Penzhorn K KERNBICHLER Doris Plöckl A GOMEZCARRILLODECASTRO

Effects of cannabis

Sensory gating

Tetrahydrocannabinol

10.1016/j.expneurol.2007.02.004

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Citations (53)

Cannabis induces different cognitive changes in schizophrenic patients and in healthy controls

Progress in Neuro-Psychopharmacology and Biological Psychiatry (2007)

Maria C. Jockers‐Scherübl Theresa Wolf Nicole Radzei Peter Schlattmann Johannes Rentzsch

Effects of cannabis

Cannabis Dependence

10.1016/j.pnpbp.2007.03.006

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Citations (119)

Electroconvulsive Monotherapy in the Treatment of Acute Confusion Psychosis

Pharmacopsychiatry (2005)

Andres H. Neuhaus Juri Katchanov Carolin Opgen‐Rhein P. Neu Maria C. Jockers‐Scherübl

This report focuses on the successful treatment of a most acute case of confusion psychosis according to the concept of Karl Leonhard. The 18-year-old patient was hospitalized three times before the current episode and his case has been characterized as pharmacologically treatment-resistant psychosis since he failed to respond to any psychopharmacological therapy including sufficient clozapine medication. In the patient’s history, typical and atypical antipsychotic as well as mood-stabilizing and sedating pharmacological treatments have been conducted. However, only adverse effects could be observed. When receiving electroconvulsive monotherapy (ECT), the patient showed a marked reduction of symptoms while experiencing no adverse effects. The implications of this finding are discussed with regard to Leonhard’s diagnostic system.

Confusion

Acute Psychosis

Antipsychotic drug

10.1055/s-2005-916192

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Citations (1)

Primary negative symptoms in schizophrenia: Treatment with paroxetine in a double-blind placebo-controlled trial

European Neuropsychopharmacology (2002)

Maria C. Jockers‐Scherübl F. Godemann Amber Bauer U. Wolfensteller

Paroxetine

10.1016/s0924-977x(02)80494-1

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Citations (1)

Negative Symptoms of Schizophrenia Are Improved by Paroxetine Added to Neuroleptics

The Journal of Clinical Psychiatry (2001)

Maria C. Jockers‐Scherübl F. Godemann Adolf Pietźcker

Article AbstractLetter to the Editor Sir: Conventional antipsychotic drugs are highly effective in alleviating positive symptoms in schizophrenia, but they have little impact on primary negative symptoms such as apathy, social withdrawal, blunted affect, and motor retardation. Atypical neuroleptics could only bridge part of this treatment gap. In the 1970s, tricyclic and tetracyclic antidepressants were added to antipsychotic treatment in chronic schizophrenia, but none improved negative symptoms consistently. Since the early 1990s, selective serotonin reuptake inhibitors such as fluvoxamine and fluoxetine have been added to neuroleptic treatment strategies on the assumption that negative symptoms might be associated with serotonergic dysfunction.

Apathy

Fluvoxamine

Tricyclic

Paroxetine

10.4088/jcp.v62n07c13

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Citations (7)

Neurotrophins - From Pathophysiology to Treatment in Alzheimers Disease

Current Alzheimer Research (2008)

Rainer Hellweg Olaf Schulte‐Herbrüggen Maria C. Jockers‐Scherübl

Alzheimers disease (AD) is the most common diagnosis among dementia. As increasing longevity results in larger numbers of AD patients and thus rising economic costs, there has been intense research about the pathophysiology and treatment strategies during the last years. Since neurotrophic factors are not only responsible for neuronal development but also critical for the maintenance of neurons, they represent mediators of high interest within the research of neurodegeneration. Thereby, NGF has been identified as a dynamic pattern during the time course of neurodegeneration in AD. Post mortem studies point to a lack of NGF action in early stages of AD. In contrast NGF is found in enhanced concentrations in brains with severe AD partly due to a pathologically altered axonal transport of NGF in the neurons. Therefore, pharmacological interventions starategies focus on an neurotrophin substitution in mild to moderate cases of AD. Intensive research mostly in rodents has recently led to first promising clinical trials of intracerebral neurotrophin application pointing to a growing role of neurotrophins in the establishment of new pharmacological strategies concerning AD. Keywords: Cholinergic system, neurotrophins, Alzheimer's disease, basal forebrain, NGF, BDNF

Pathophysiology

10.2174/156720508783884620

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Citations (68)

From Wish to Reality: Soteria in Regular Care—Proof of Effectiveness of the Implementation of Soteria Elements in Acute Psychiatry

Frontiers in Psychiatry (2021)

Theresa Wolf Philine Fabel Adrian Kraschewski Maria C. Jockers‐Scherübl

Objective: This article examines the influence of the implementation of Soteria elements on coercive measures in an acute psychiatric ward after reconstruction in 2017, thereby comparing the year 2016 to the year 2019. The special feature is that this is the only acute psychiatric ward in Hennigsdorf Hospital, connected now both spatially and therapeutically to an open ward and focusing on the treatment of patients suffering from schizophrenia and schizophrenia spectrum disorders. Methods: The following parameters were examined: aggressive assaults, use of coercion (mechanical restraints), duration of treatment in open or locked ward, type of discharge, coercive medication, and dosage of applied antipsychotics. For this purpose, the data of all legally accommodated patients in the year 2016 (before the reconstruction) and 2019 (after the reconstruction) were statistically analyzed in a pre–post mirror quasi-experimental design. Results: In 2019, the criteria of the Soteria Fidelity Scale for a ward with Soteria elements were reached. In comparison to 2016 with a comparable care situation and a comparable patient clientele, there was now a significant decrease in aggressive behavior toward staff and fellow patients, a significantly reduced number of fixations, a significantly reduced overall duration of inpatient stay, and a significant increase in treatment time in the open area of our acute ward. Conclusion: The establishment of Soteria elements in the acute psychiatric ward leads to a verifiable less violent environment of care for severely ill patients and to a drastic reduction in coercive measures.

Coercion (linguistics)

Psychiatric ward

Acute care

Acute Psychosis

Acute hospital

Psychomotor agitation

10.3389/fpsyt.2021.685779

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Citations (7)

Massive Creatine Kinase Elevations with Quetiapine: Report of Two Cases

Pharmacopsychiatry (2006)

Jan Philipp Klein Ute Fiedler H. Appel Arnim Quante Maria C. Jockers‐Scherübl

Massive elevations of serum creatine kinase (CK) can occur in a significant number of patients treated with neuroleptics in the absence of neuroleptic malignant syndrome (NMS). We report two cases of CK-elevations associated with quetiapine treatment, which disappeared after drug discontinuation. To our knowledge, case number one is the first case of quetiapine-induced CK elevation in a neuroleptic-naïve patient. We thus suggest CK assessment when myalgia occurs with neuroleptic treatment.

Discontinuation

Creatine kinase

Quetiapine Fumarate

myalgia

Neuroleptic Malignant Syndrome

10.1055/s-2006-931478

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Citations (19)

Step away from depression—results from a multicenter randomized clinical trial with a pedometer intervention during and after inpatient treatment of depression

European Archives of Psychiatry and Clinical Neuroscience (2023)

Julia Große Charlotte Huppertz Astrid Röh Viola Oertel Sara Andresen

Abstract Evidence for the effectiveness of physical activity (PA) in the treatment of depression prevails for outpatients with mild and moderate symptom levels. For inpatient treatment of severe depression, evidence-based effectiveness exists only for structured and supervised group PA interventions. The Step Away from Depression (SAD) study investigated the effectiveness of an individual pedometer intervention (PI) combined with an activity diary added to inpatient treatment as usual (TAU). In this multicenter randomized controlled trial, 192 patients were randomized to TAU or TAU plus PI. The two primary outcomes at discharge were depression—blindly rated with the Montgomery–Åsberg Depression Rating Scale (MADRS)—and average number of daily steps measured by accelerometers. Secondary outcomes were self-rated depression and PA, anxiety, remission and response rates. Multivariate analysis of variance (MANOVA) revealed no significant difference between both groups for depression and daily steps. Mean MADRS scores at baseline were 29.5 (SD = 8.3) for PI + TAU and 28.8 (SD = 8.1) for TAU and 16.4 (SD = 10.3) and 17.2 (SD = 9.9) at discharge, respectively. Daily steps rose from 6285 (SD = 2321) for PI + TAU and 6182 (SD = 2290) for TAU to 7248 (SD = 2939) and 7325 (SD = 3357). No differences emerged between groups in secondary outcomes. For severely depressed inpatients, a PI without supervision or further psychological interventions is not effective. Monitoring, social reinforcement and motivational strategies should be incorporated in PA interventions for this population to reach effectiveness.

Depression

Pedometer

10.1007/s00406-023-01646-2

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Citations (1)

Auditory Mismatch Negativity and Repetition Suppression Deficits in Schizophrenia Explained by Irregular Computation of Prediction Error

PLoS ONE (2015)

Johannes Rentzsch Christina Shen Maria C. Jockers‐Scherübl Jürgen Gallinat Andres H. Neuhaus

Background The predictive coding model is rapidly gaining attention in schizophrenia research. It posits the neuronal computation of residual variance ('prediction error') between sensory information and top-down expectation through multiple hierarchical levels. Event-related potentials (ERP) reflect cortical processing stages that are increasingly interpreted in the light of the predictive coding hypothesis. Both mismatch negativity (MMN) and repetition suppression (RS) measures are considered a prediction error correlates based on error detection and error minimization, respectively. Methods Twenty-five schizophrenia patients and 25 healthy controls completed auditory tasks designed to elicit MMN and RS responses that were investigated using repeated measures models and strong spatio-temporal a priori hypothesis based on previous research. Separate correlations were performed for controls and schizophrenia patients, using age and clinical variables as covariates. Results MMN and RS deficits were largely replicated in our sample of schizophrenia patients. Moreover, MMN and RS measures were strongly correlated in healthy controls, while no correlation was found in schizophrenia patients. Single-trial analyses indicated significantly lower signal-to-noise ratio during prediction error computation in schizophrenia. Conclusions This study provides evidence that auditory ERP components relevant for schizophrenia research can be reconciled in the light of the predictive coding framework. The lack of any correlation between the investigated measures in schizophrenia patients suggests a disruption of predictive coding mechanisms in general. More specifically, these results suggest that schizophrenia is associated with an irregular computation of residual variance between sensory input and top-down models, i.e. prediction error.

10.1371/journal.pone.0126775

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Citations (42)