S. Haque Nizamie

Central Institute of Psychiatry

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Nishant Goyal

Central Institute of Psychiatry

Sai Krishna Tikka

All India Institute of Medical Sciences

Harpreet S. Duggal

Kaiser Permanente Walnut Creek Medical Center

Karuppiah Jagadheesan

Royal Australian and New Zealand College of Psychiatrists

Samir Kumar Praharaj

Manipal Academy of Higher Education

Mohammad Zia Ul Haq Katshu

Institute of Mental Health

Biswa Ranjan Mishra

All India Institute of Medical Sciences Bhubaneswar

Alka Nizamie

Seva Mandir

Sayantanava Mitra

Monash Health

Vinod Kumar Sinha

Central Institute of Psychiatry

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Central Institute of Psychiatry

UNSW Sydney

Harvard University

Creative Commons

All India Institute of Medical Sciences

All India Institute of Medical Sciences Raipur

National Institute of Mental Health and Neurosciences

University of Washington

Columbia University

Massachusetts General Hospital

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Efficacy of repetitive transcranial magnetic stimulation in alcohol dependence: a sham‐controlled study

Addiction (2009)

Biswa Ranjan Mishra S. Haque Nizamie Basudeb Das Samir Kumar Praharaj

ABSTRACT Objective To study the anticraving efficacy of high‐frequency repetitive transcranial magnetic stimulation (rTMS) of the right dorsolateral pre‐frontal cortex (DLPFC) in patients with alcohol dependence. Methods We performed a prospective, single‐blind, sham‐controlled study involving 45 patients with alcohol dependence syndrome (according to ICD‐10 DCR), with Clinical Institute of Withdrawal Assessment in Alcohol Withdrawal (CIWA‐Ar) scores ≤10. Patients were allocated to active and sham rTMS in a 2 : 1 ratio, such that 30 patients received active and 15 patients sham rTMS to the right DLPFC (10 Hz frequency, 4.9 seconds per train, inter‐train interval of 30 seconds, 20 trains per session, total 10 sessions). The Alcohol Craving Questionnaire (ACQ‐NOW) was administered to measure the severity of alcohol craving at baseline, after the last rTMS session and after 1 month of the last rTMS session. Results Two‐way repeated‐measures analysis of variance (ANOVA) showed significant reduction in the post‐rTMS ACQ‐NOW total score and factor scores in the group allocated active rTMS compared to the sham stimulation. The effect size for treatment with time interaction was moderate (η 2 = 0.401). Conclusions Right dorsolateral pre‐frontal high‐frequency rTMS was found to have significant anticraving effects in alcohol dependence. The results highlight the potential of rTMS which, combined with other anticraving drugs, can act as an effective strategy in reducing craving and subsequent relapse in alcohol dependence.

Repeated measures design

Alcohol Dependence

Dorsolateral prefrontal cortex

10.1111/j.1360-0443.2009.02777.x

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Citations (222)

Evaluation of spontaneous dense array gamma oscillatory activity and minor physical anomalies as a composite neurodevelopmental endophenotype in schizophrenia

International Journal of Developmental Neuroscience (2014)

Sai Krishna Tikka S. Haque Nizamie Nishant Goyal N. Pradhan Deyashini Lahiri Tikka

Minor physical anomalies (MPAs) and gamma oscillatory activity have been proposed as associated endophenotypes in schizophrenia. Combining these endophenotypes to create a composite endophenotype may help identify those at risk for schizophrenia better. The present study aims to investigate MPAs and gamma oscillatory activity in schizophrenia patients, their unaffected first degree relatives and healthy controls and appreciate whether they can be used together as a composite endophenotype.This was a cross sectional family study conducted at a tertiary care mental health setup. Ninety participants including schizophrenia patients, their first degree relatives and controls (thirty each) were assessed for MPAs on the Extended Waldrop Scale. All participants underwent an awake, resting 192-channel EEG recording. Spectral power and coherence in 30-100Hz gamma bands were estimated using Welch's averaged periodogram method. One-way ANOVA, chi square test were used for comparing socio-demographic-clinical variables. MANOVA supplemented by one-way ANOVAs (post hoc Tukey HSD) were done for comparison of spectral measures. Pearson's correlation, step-by-step linear discriminant functional and intra-familial correlation analysis were subsequently performed.An endophenotype pattern of finding was found for MPAs in the craniofacial region, the total number of MPAs, spectral power in right temporal region on all bands and in the right parietal region in 50-70Hz and 70-100Hz gamma bands. The three groups were most accurately classified when MPA total score, right temporal 30-50Hz gamma power and right occipital 'intra hemispheric' 50-70Hz gamma coherence were considered together than when considered independently. Significant intra familial correlation was seen for MPA total score and right temporal gamma 30-50Hz power.Composite evaluation of two developmentally linked markers i.e. MPAs and gamma spectral measures may prove useful in categorizing schizophrenia and identifying at-risk individuals.

Endophenotype

10.1016/j.ijdevneu.2014.11.002

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Citations (16)

CASE REPORT - Bereitschaftspotential in Tic Disorders : A Preliminary Observation

Harpreet S. Duggal S. Haque Nizamie

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Risk factors and outcome of mood disorders in epilepsy: a case-control study

Seizure (2003)

Karuppiah Jagadheesan ASHWANI K GARG S. Haque Nizamie

10.1016/s1059-1311(02)00192-9

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Citations (14)

Publication concerning an article single CT (ring) lesion in epilepsy patients : A new observation by Garget al Indian Journal of Pediatrics, January-February, 1999, vol.66, No.1, pages 155-157

The Indian Journal of Pediatrics (1999)

H. S. Duggal S. Haque Nizamie

10.1007/bf02723876

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Schneiderian first rank symptoms in schizophrenia: A developmental neuroscience evaluation

International Journal of Developmental Neuroscience (2016)

Sai Krishna Tikka S. Haque Nizamie Archana Kumari Das Nidhi Agarwal Nishant Goyal

Abstract Introduction Self disorders in schizophrenia have been suggested to have distinct neurobiological underpinnings. Using comprehensive neuro‐scientific assessments including a neurophysiological, a neurochemical and a neuropsychological marker, this study assesses disordered‐“self” in schizophrenia. Methods Twenty schizophrenia patients with first rank symptoms (FRS;FRS+), 20 patients without FRS (FRS−) and 20 healthy controls (HC) were assessed for psychopathology, especially on specially designed FRS score sheets with a narrow and a broad definition. Resting state electroencephalography was acquired using 256‐electrodes; gamma spectral‐power was measured in 8 regions of interest. Serum BDNF and self‐monitoring were also assessed. Comparative and correlation analysis were conducted in addition to a step‐wise discriminant function analysis. Results FRS+ group with greater positive symptom score and a lower negative symptom score, showed significantly increased gamma spectral power, especially on right hemispheric regions, along with lower BDNF levels and lower scores on self‐monitoring compared to FRS− and HC. Serum BDNF levels and gamma spectral power in the region corresponding right inferior parietal lobule were identified as predictors that most accurately classified the defined groups. Conclusions Schizophrenia patients satisfying the criteria of presence of first rank symptoms represent a distinct neurodevelopmental subgroup with associated features of predominantly positive symptoms, significantly lower neurotrophin levels, aberrant resting state brain activity in the heteromodal association cortex and performing poorer on self‐monitoring tasks.

Neurochemical

10.1016/j.ijdevneu.2016.02.001

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Citations (6)

Cognitive Functioning in Remitted Bipolar Patients

S. Haque Nizamie Neha Sayeed

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Efficacy of Adjuvant High Frequency Repetitive Transcranial Magnetic Stimulation on Negative and Positive Symptoms of Schizophrenia: Preliminary Results of a Double-Blind Sham-Controlled Study

Journal of Neuropsychiatry (2007)

Nishant Goyal S. Haque Nizamie Pushpal Desarkar

The potential effect of repetitive transcranial magnetic stimulation (rTMS) on core positive and negative symptoms in schizophrenia has not yet been clearly established. The aim of this study was to examine the efficacy of adjuvant 10 Hz, suprathreshold left prefrontal rTMS in negative symptoms of schizophrenia in a double-blind sham-controlled design. Additionally, our study also investigated the suitability of applying the same stimulus condition on positive symptoms. Ten right-handed schizophrenia patients received sham or active 10 Hz suprathreshold rTMS to the left dorsolateral prefrontal cortex with psychopathology, depression and global improvement ratings before and after rTMS sessions. Compared to sham, active rTMS significantly improved negative symptoms, irrespective of change in depressive symptoms.

Stimulus (psychology)

Depression

10.1176/jnp.2007.19.4.464

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Citations (59)

Efficacy of Paroxetine in Primary Palmoplantar Hyperhidrosis Occurring with Juvenile Myoclonic Epilepsy

Dermatology (2011)

Mohammad Zia Ul Haq Katshu Arnab Bhattacharya S. Haque Nizamie

Primary palmoplantar hyperhidrosis (PPH) is believed to be a dysfunction of emotional sweating, with an estimated prevalence of around 3%. Several treatment options including topical antiperspirants, tap water iontophoresis, botulinum toxin injections, oral anticholinergics, and tricyclic antidepressants are available, each with a significant adverse event profile. For the first time, we report a PPH patient with comorbid juvenile myoclonic epilepsy (JME) treated successfully with a combination of paroxetine and divalproex sodium. Paroxetine resulted in improvement in PPH, possibly through its anticholinergic and/or noradrenergic actions. Though the occurrence of PPH and JME together seems to be a chance association, some common frontal lobe mechanisms may be involved that need to be explored further.

Juvenile myoclonic epilepsy

Paroxetine

Myoclonic Jerk

Anticholinergic agents

10.1159/000330559

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Effectiveness of Continuing Nursing Education Program in Child Psychiatry

Journal of Child and Adolescent Psychiatric Nursing (2006)

Nirmalya Chakraborty Baxi Neeraj Prasad Sinha S. Haque Nizamie Vinod Kumar Sinha Sayeed Akhtar

Program evaluation of the effectiveness of two continuing nursing education programs (CNE) in child psychiatry in India.Pre- and postevaluation of a total of 51 nurses attending a 10-day CNE program, using a 30-item (six-domain) questionnaire according to CNE topics in child psychiatry.The CNE program resulted in significant increase in the total scores as well as scores in several sub-domains in the field of child psychiatry.In a country that does not offer degree programs that integrate psychiatric nursing into the curriculum, CNE programs are an important educational option for nurses. The CNE program offered in this study, comprising lectures, discussion, interactive sessions, and case demonstrations totaling 60 hr across 10 days, was effective in improving the level of knowledge of nurses. It was equally beneficial for senior as well as less experienced nurses.

Educational program

10.1111/j.1744-6171.2006.00039.x

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Citations (10)