Dhanalekshmi UM

Muscat College

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Shah Alam Khan

The University of Agriculture, Peshawar

Khouloud Hachani

Technical University of Munich

NAS. Nik Nur Dayana

Fahd Othmani

Muscat College

Pawan K. Dhar

Jawaharlal Nehru University

Raniah R Majeed

Oman Medical College

Kedah Darul Aman

Friedrich-Alexander-Universität Erlangen-Nürnberg

Gurpreet KN

Muscat College

Alaa M Soliman

Oman Medical College

Rehab Khokar

Muscat College

Cooperative Institutions

Muscat College

Oman Medical College

Saveetha University

Pondicherry University

Jamia Hamdard

National University of Science and Technology

Technical University of Munich

Klinikum rechts der Isar

Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde

Jawaharlal Nehru University

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Evaluation of Phytochemicals and Antioxidant Properties of Leaves, Fruits and Stems of Ficus deltoidea Plant Extract

Annals of biological research (2017)

Usha Kumari R Ayyappadhas Dhanalekshmi UM

The fundamental mechanism underlying a number of human neurodegenerative disorders, diabetes, inflammation, viral infections, autoimmune pathologies and digestive system disorders due to free radicals or reactive oxygen species (ROS). World is blessed with mammoth biodiversity resources, but overwhelmed with several diseases, including those with ROS as the etiological factor. In the present study, the antioxidant activity, total phenolic and flavonoids content of different parts of the plant F. deltoidea, collected from three different areas in Malaysia has been evaluated. Plant extract exhibited strong antioxidant activity. Methanolic extract of F. deltoidea possess more antioxidant principles than aqueous extracts. Among the three sources, F. deltoidea 1 (FD1) possess higher antioxidant activity than the others [FD2 and FD3]. In the present study, we discovered that fruits of F. deltoidea contain more antioxidant principles and free radical scavenging activity and the effects are significantly comparable with standard antioxidants

Ficus

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Role of the Gut Microbiome in Diabetes and Cardiovascular Diseases Including Restoration and Targeting Approaches- A Review

Drug Metabolism and Bioanalysis Letters (2022)

Alka Ahuja Dhanalekshmi UM Saraswathy MP S Nandakumar Arul Prakash Francis

Metabolic diseases, including cardiovascular diseases (CVD) and diabetes, have become the leading cause of morbidity and mortality worldwide. Gut microbiota appears to play a vital role in human disease and health, according to recent scientific reports. The gut microbiota plays an important role in sustaining host physiology and homeostasis by creating a cross-talk between the host and microbiome via metabolites obtained from the host's diet. Drug developers and clinicians rely heavily on therapies that target the microbiota in the management of metabolic diseases, and the gut microbiota is considered the biggest immune organ in the human body. They are highly associated with intestinal immunity and systemic metabolic disorders like CVD and diabetes and are reflected as potential therapeutic targets for the management of metabolic diseases. This review discusses the mechanism and interrelation between the gut microbiome and metabolic disorders. It also highlights the role of the gut microbiome and microbially derived metabolites in the pathophysiological effects related to CVD and diabetes. It also spotlights the reasons that lead to alterations of microbiota composition and the prominence of gut microbiota restoration and targeting approaches as effective treatment strategies in diabetes and CVD. Future research should focus onunderstanding the functional level of some specific microbial pathways that help maintain physiological homeostasis, multi-omics, and develop novel therapeutic strategies that intervene with the gut microbiome for the prevention of CVD and diabetes that contribute to a patient's well-being.

Gut microbiome

10.2174/2949681015666220615120300

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Identification and Prevalence of Food Colors in Candies Commonly Consumed by Children in Muscat, Oman

International journal of Nutrition Pharmacology Neurological Diseases (2021)

Majed AbuKhader Dhanalekshmi UM Abdulsalam Nazmi

Background: A food color, or a color additive, is any dye, pigment, or a chemical substance that imparts colors to food. There have been several concerns about the safety of food colors reported in the literature that require further evaluation. Purpose: The aim of this study was to identify the type, synthetic and natural, frequency, and prevalence of food colors in candy confectionary items commonly consumed by children. Methods: A random cross-sectional product survey approach was followed in selected supermarkets and convenience stores in Muscat, Oman. The ingredient label was utilized as a reliable source of information about food colors used in the selected candy confectionery items. Results: A greater variety of natural food colors were used in candy confectionery when compared with the synthetic ones. It seems, however, that synthetic food colors were more frequently used. Brilliant Blue FCF (E133) and Allura Red AC (E129) are synthetic food colors used more frequently in the studied sample. Although a general observation of the collected data highlights some variation in the frequency of food colors used in candy confectionery sold in supermarkets and convenience stores, statistical analysis has revealed an insignificant correlation. Conclusion: Both synthetic and natural food colors were found to be used in the studied sample. There was no correlation between the type of food colors used in candies and the outlets where these items were sold. This research encourages further exploration of consumption patterns among young children and the actual levels of food colors in food items including candy confectionery marketed in Oman.

Ingredient

Food Products

10.4103/ijnpnd.ijnpnd_2_21

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Anti-Alzheimer potential of a waste by-product (peel) of Omani pomegranate fruits: Quantification of phenolic compounds, in-vitro antioxidant, anti-cholinesterase and in-silico studies

Biocatalysis and Agricultural Biotechnology (2021)

Rehab Khokar Khouloud Hachani Mariya Hasan Fahd Othmani Mohammad Essam

Phytochemical

Punica

10.1016/j.bcab.2021.102223

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PRELIMINARY STUDIES ON ANTIMICROBIAL ACTIVITY OF SWIETENIA MACROPHYLLA LEAF EXTRACT Research Article

C Jestin Ngure Kenneth NAS. Nik Nur Dayana Dhanalekshmi UM Kedah Darul Aman

The plant Swietenia macrophylla belonging to the family Meliaceae is a traditionally important plant with more medicinal properties. Phytochemical investigation of crude extracts of Swietenia macrophylla resulted in the identification of various chemical constituents. The crude extracts were also tested against human pathogenic bacteria and fungal strains. Based on minimum inhibitory concentration (MIC) of the present study, the plant extract has antibacterial activity as well as good antifungal activity. This study supports the traditional claim and usefulness of the plant.

Swietenia macrophylla

Phytochemical

Meliaceae

Pathogenic bacteria

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Phytochemical and Pharmacological Aspects of Cissus quadrangularis in Ayurveda

The Royal Society of Chemistry eBooks (2022)

Dhanalekshmi UM Jawaid Akhtar Shah Alam Khan

Cissus quadrangularis L. (family: Vitaceae) is an indigenous medicinal plant of India. It is used to treat several acute and chronic ailments, including bone-related disorders in Ayurveda. This chapter documents various bioactive metabolites isolated from C. quadrangularis. A detailed account of its in vitro and in vivo pharmacological activities, along with plausible mechanisms have been covered in this review. Few clinical studies have been conducted to evaluate its role in bone diseases and in weight loss. Light has been shed on its application and patents which have been granted to help the scientific community to explore the future therapeutic and scientific potential of this plant. Data from several acute and sub-chronic animal studies indicate that daily use of C. quadrangularis stem powder or extract for 90 days does not produce any unwanted side effects. However, there is a scarcity of data on their long-term clinical use in humans. Further preclinical investigations depicting the deep molecular pathways, potential, and mechanistic insights of phytoconstituents are warranted for in-depth scientific knowledge about this pharmaceutically important medicinal plant. Also, more randomized clinical trials are needed to establish the safety and efficacy of this miraculous Ayurvedic medicine in the management and treatment of various ailments.

Phytochemical

Vitaceae

10.1039/9781839166211-00289

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In vitro Cytotoxic, Antioxidant and Antimicrobial Activities of Alcoholic and Chloroform Extracts of Dhofari Frankincense

Dhaka University Journal of Pharmaceutical Sciences (2020)

Alaa M Soliman Raniah R Majeed Hala F Ali Himyari Dhanalekshmi UM Shah Alam Khan

Omani (Dhofari) frankincense is world famous for its high quality and fragrance. The oleo-gum resin obtained from the tree of Omani species i.e., Boswellia sacra (local name: luban) is widely used by the natives. The aim of the study was to determine the presence of phytochemicals in chloroform and ethanol extracts of B. sacra resin and to evaluate the in vitro cytotoxic, antimicrobial- and antioxidant-activities. The ethanol and chloroform extracts of Hojari luban were obtained in good yield. The extracts were subjected to phytochemical screenings, quantification of total phenolics (TP) and evaluation of in vitro biological activities viz. antioxidant, antibacterial and cytotoxic potential. The bioactivities of four boswellic acids, the major constituents of the oleo-gum resin, were also predicted with the help of PASS and CLC-pred software. Both the extracts showed similar level of TP (14.67 mg/g and 14.79 mg/g in terms of gallic acid equivalent) but polar fraction was noted to be more active against E. coli. A moderate antioxidant activity was shown by the resin extracts however their cytotoxic activity was observed to be quite remarkable at 1000 μg/l which could be attributed to their high boswellic acid content. Results of in silico PASS studies showed boswellic acids to possess an array of useful biological activities including chemopreventive activity. Further, CLC-pred software revealed that only keto boswellic acid is expected to exert antineoplastic activity against pancreatic carcinoma cell lines, however all the four major boswellic acids are likely to be active against non-tumor embryonic lung fibroblast (MRC5). The study confirmed that frankincense is rich in bioactive metabolites which are of significant economic and therapeutic importance. Dhaka Univ. J. Pharm. Sci. 19(2): 105-110, 2020 (December)

Phytochemical

10.3329/dujps.v19i2.50624

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Fibroadenoma and breast cancer patientsâ lymphocytes sensitivity to gamma rays- An evaluation by micronuclei assay

Annals of biological research (2013)

Usha Kumari Pawan K. Dhar Dhanalekshmi UM Gopala Krishna Bhat

Micronuclei [MN] in lymphocytes of patients suffering from fibroadenoma [n=29] and breast cancer [n=37] was compared with the data from healthy individuals [n=10]. Healthy controls lymphocytes were exposed at G0 stage to different doses [0.5 Gy, 1.0 Gy, 2.0 Gy and 4.0 Gy] of γ-rays. Lymphocytes were cultured for 72 hours to obtain MN with cytochalasin B. A dose dependent increase in the incidence of MN frequency and a decrease in the survival of lymphocytes. Frequency of PBLs [Peripheral blood lymphocytes] with one, two, three and four MN is analyzed. In comparison to baseline, the radiation exposed samples showed higher frequency of MN in control, fibroadenoma and breast cancer. The degree of increase was 4.7 times in control, 10.8 in fibroadenoma and 15.2 in breast cancer as compared to samples without radiation. The overall degree of increase in MN frequency from control to breast cancer was 3.2 times. Non irradiated and irradiated samples showed an increase in MN frequency from stage I to stage IV. Influence of age on MN frequency was not significant. MN assay is an additional diagnostic, prognostic tool in benign and malignant tumors of breast to assess the degree of genetic damage and radiosensitivity.

Radiosensitivity

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