Liang Xu

Capital Medical University

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Jost B. Jonas

Heidelberg University

Ya Xing Wang

Beijing Tongren Hospital

Qi Sheng You

Kresge Eye Institute

Wen Bin Wei

Beijing Tongren Hospital

Hua Yang

Chinese Institute for Brain Research

Jie Xu

Capital Medical University

Tien Yin Wong

National University of Singapore

E. Shyong Tai

National University of Singapore

Ching‐Yu Cheng

National University of Singapore

Chiea Chuen Khor

Agency for Science, Technology and Research

Cooperative Institutions

Capital Medical University

182

Beijing Tongren Hospital

121

Shandong First Medical University

Peking University

Singapore Eye Research Institute

National University of Singapore

Chinese Academy of Medical Sciences & Peking Union Medical College

Singapore National Eye Center

Shandong Tumor Hospital

Shandong University

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Ten-Year Progression of Myopic Maculopathy

Ophthalmology (2018)

Yan Ni Yan Ya Xing Wang Yan Yang Liang Xu Jie Xu

Fundus (uterus)

10.1016/j.ophtha.2018.01.035

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Citations (124)

Efficacy and safety of pyrotinib combined with albumin‐bound paclitaxel as first‐line treatment for HER2‐positive metastatic breast cancer in patients previously treated with adjuvant and/or neoadjuvant trastuzumab therapy: The stage 1 results of a single‐arm, phase 2 prospective clinical trial

Clinical and Translational Medicine (2024)

Xiaochu Man Jie Huang Shujuan Sun Dongdong Zhou Baoxuan Zhang

Abstract Objective It has been observed that the prognosis of patients with HER2‐positive metastatic breast cancer has improved significantly with HER2‐targeted agents. However, there is still a lack of evidence regarding first‐line anti‐HER2 treatment options for patients who have received adjuvant and/or neoadjuvant trastuzumab for HER2‐positive metastatic breast cancer. Besides, there are no reliable markers that can predict the efficacy of anti‐HER2 treatment in these patients. Methods Patients who have received adjuvant and/or neoadjuvant trastuzumab for HER2‐positive metastatic breast cancer were enrolled. Pyrotinib plus albumin‐bound paclitaxel were used as first‐line treatment. The primary endpoint was the objective response rate (ORR). The safety profile was also assessed. In order to explore predictive biomarkers using Olink technology, blood samples were collected dynamically. Results From December 2019 to August 2023, the first stage of the study involved 27 eligible patients. It has not yet reached the median PFS despite the median follow‐up being 17.8 months. Efficacy evaluation showed that the ORR was 92.6%, and the DCR was 100%. Adverse events of grade 3 or higher included diarrhoea (29.6%), leukopenia (11.1%), neutropenia (25.9%), oral mucositis (3.7%), and hand‐foot syndrome (3.7%). Toll‐like receptor 3 (TLR3) and Proto‐oncogene tyrosine‐protein kinase receptor (RET) were proteins with significant relevance to PFS in these patients. Conclusions This study demonstrates that pyrotinib plus albumin‐bound paclitaxel as a first‐line treatment regimen shows good efficacy and manageable safety for patients who have received adjuvant and/or neoadjuvant trastuzumab for HER2‐positive metastatic breast cancer. Besides, a significant association was identified between the expression levels of TLR3 and RET and the PFS in patients.

Regimen

Leukopenia

10.1002/ctm2.1687

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Corneal Nerve Structure and Function in Patients With Non-Sjögren Dry Eye: Clinical Correlations

Investigative Ophthalmology & Visual Science (2013)

Antoine Labbé Qingfeng Liang Zhiqun Wang Yang Zhang Liang Xu

To evaluate the relationship between the in vivo confocal microscopic (IVCM) morphology of subbasal corneal nerves, corneal sensitivity, and clinical parameters in patients with non-Sjögren dry eye disease (NSDD).Forty-three patients with NSDD and 14 healthy age- and sex-matched control subjects were included. Each patient underwent an evaluation of ocular surface disease symptoms using the Ocular Surface Disease Index (OSDI); tear film break-up time (TBUT); corneal and conjunctival staining (Oxford scale); the Schirmer test; corneal sensation testing using the Cochet-Bonnet esthesiometer; and corneal subbasal nerve analysis with IVCM. One eye of each subject was included in the study.Mean corneal sensitivity was significantly lower in the NSDD group as compared with the control group (P = 0.014). Corneal subbasal nerves showed significant changes in NSDD patients as compared with normal subjects: lower density (P < 0.001); increased tortuosity (P < 0.001); number of beadings (P < 0.001); and width (P = 0.041). In patients with NSDD, corneal subbasal nerve density was correlated to age (r = -0.352, P = 0.021); the Oxford scale (r = -0.486, P = 0.01); and central corneal sensitivity (r = 0.383, P = 0.041). The maximum length of nerve fibers within a frame (MaxL) was correlated to the OSDI (r = -0.265, P = 0.019) and the Oxford scale (r = -0.307, P = 0.039). In multivariate analysis after adjustment for age, corneal subbasal nerve density remained correlated to the Oxford score (P < 0.001). The Oxford score was also correlated to central corneal sensitivity (r = -0.304, P = 0.042).NSDD patients have both structural and functional alterations of subbasal corneal nerves and these changes are related to the severity of dry eye.

Schirmer test

10.1167/iovs.13-12370

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Citations (185)

Fundus Tessellation: Prevalence and Associated Factors

Ophthalmology (2015)

Yan Ni Yan Ya Xing Wang Liang Xu Jie Xu Wen Bin Wei

Fundus (uterus)

10.1016/j.ophtha.2015.05.031

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Citations (104)

Prevalence of Age-related Maculopathy in the Adult Population in China: The Beijing Eye Study

American Journal of Ophthalmology (2006)

Yibin Li Liang Xu Jost B. Jonas Hua Yang Yingnan Ma

Fundus Photography

Age-related maculopathy

Fundus (uterus)

10.1016/j.ajo.2006.06.001

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Citations (130)

Nine Loci for Ocular Axial Length Identified through Genome-wide Association Studies, Including Shared Loci with Refractive Error

The American Journal of Human Genetics (2013)

Ching‐Yu Cheng Maria Schäche M. Kamran Ikram Terri L. Young Jeremy A. Guggenheim

Genome-wide Association Study

Genetic Association

10.1016/j.ajhg.2013.06.016

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Citations (146)

Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium

Scientific Reports (2016)

Qiao Fan Xiaobo Guo J. Willem L. Tideman Katie Williams Seyhan Yazar

Abstract Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci associated with refractive error and myopia. Here, the age-of-onset of association between genetic variants at these 39 loci and refractive error was investigated in 5200 children assessed longitudinally across ages 7–15 years, along with gene-environment interactions involving the major environmental risk-factors, nearwork and time outdoors. Specific variants could be categorized as showing evidence of: (a) early-onset effects remaining stable through childhood, (b) early-onset effects that progressed further with increasing age, or (c) onset later in childhood (N = 10, 5 and 11 variants, respectively). A genetic risk score (GRS) for all 39 variants explained 0.6% (P = 6.6E–08) and 2.3% (P = 6.9E–21) of the variance in refractive error at ages 7 and 15, respectively, supporting increased effects from these genetic variants at older ages. Replication in multi-ancestry samples (combined N = 5599) yielded evidence of childhood onset for 6 of 12 variants present in both Asians and Europeans. There was no indication that variant or GRS effects altered depending on time outdoors, however 5 variants showed nominal evidence of interactions with nearwork (top variant, rs7829127 in ZMAT4 ; P = 6.3E–04).

Genome-wide Association Study

Genetic Association

10.1038/srep25853

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Citations (96)

Prevalence of Diabetic Retinopathy and Vision Loss in the Beijing Eye Study: the Potential Role of the Cerebrospinal Fluid Pressure

Current Diabetes Reports (2015)

Jost B. Jonas Liang Xu Jie Xu Wen Bin Wei Ya Xing Wang

Cerebrospinal fluid pressure

10.1007/s11892-015-0649-7

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Citations (7)