Héctor Freilij

Hospital General de Niños Ricardo Gutierrez

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Jaime Altcheh

Hospital General de Niños Ricardo Gutierrez

Guillermo Moscatelli

Hospital General de Niños Ricardo Gutierrez

Griselda Ballering

Hospital General de Niños Ricardo Gutierrez

Samanta Moroni

Hospital General de Niños Ricardo Gutierrez

Facundo García‐Bournissen

Western University

Margarita Bisio

Consejo Nacional de Investigaciones Científicas y Técnicas

M. Biancardi

Boston Children's Hospital

Alejandro G. Schijman

Consejo Nacional de Investigaciones Científicas y Técnicas

Juan M. Burgos

Consejo Nacional de Investigaciones Científicas y Técnicas

Nicolás González

Hospital General de Niños Ricardo Gutierrez

Cooperative Institutions

Hôpital Xavier Arnozan

257

Consejo Nacional de Investigaciones Científicas y Técnicas

Hospital General de Niños Ricardo Gutierrez

University of Buenos Aires

Inserm

Centers for Disease Control and Prevention

Johns Hopkins University

Office of Infectious Diseases

National Institutes of Health

Ministerio de Salud

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Chagas Disease

Birkhäuser advances in infectious diseases (2019)

Jaime Altcheh Héctor Freilij

This book offers a comprehensive overview of Chagas disease, including its vectorial and congenital transmission, as well as molecular diagnosis, which is essential for screening. Pathogenesis of the disease and the development of timely, effective anti-trypanosomal treatments are discussed.

Chagas Disease

Pathogenesis

10.1007/978-3-030-00054-7

Cite

Citations (12)

Improved vector control of Triatoma infestans limited by emerging pyrethroid resistance across an urban-to-rural gradient in the Argentine Chaco

Parasites & Vectors (2021)

María Sol Gaspe Marta Victoria Cardinal María del Pilar Fernández Claudia Vassena Pablo Luis Santo‐Orihuela

The sustainable elimination of Triatoma infestans in the Gran Chaco region represents an enduring challenge. Following the limited effects of a routine pyrethroid insecticide spraying campaign conducted over 2011-2013 (first period) in Avia Terai, an endemic municipality with approximately 2300 houses, we implemented a rapid-impact intervention package to suppress house infestation across the urban-to-rural gradient over 2015-2019 (second period). Here, we assess their impacts and whether persisting infestations were associated with pyrethroid resistance.The 2011-2013 campaign achieved a limited detection and spray coverage across settings (< 68%), more so during the surveillance phase. Following community mobilization and school-based interventions, the 2015-2019 program assessed baseline house infestation using a stratified sampling strategy; sprayed all rural houses with suspension concentrate beta-cypermethrin, and selectively sprayed infested and adjacent houses in urban and peri-urban settings; and monitored house infestation and performed selective treatments over the follow-up.Over the first period, house infestation returned to pre-intervention levels within 3-4 years. The adjusted relative odds of house infestation between 2011-2013 and 2015-2016 differed very little (adj. OR: 1.17, 95% CI 0.91-1.51). Over the second period, infestation decreased significantly between 0 and 1 year post-spraying (YPS) (adj. OR: 0.36, 95% CI 0.28-0.46), with heterogeneous effects across the gradient. Mean bug abundance also dropped between 0 and 1 YPS and thereafter remained stable in rural and peri-urban areas. Using multiple regression models, house infestation and bug abundance at 1 YPS were 3-4 times higher if the house had been infested before treatment, or was scored as high-risk or non-participating. No low-risk house was ever infested. Persistent foci over two successive surveys increased from 30.0 to 59.3% across the gradient. Infestation was more concentrated in peridomestic rather than domestic habitats. Discriminating-dose bioassays showed incipient or moderate pyrethroid resistance in 7% of 28 triatomine populations collected over 2015-2016 and in 83% of 52 post-spraying populations.The intervention package was substantially more effective than the routine insecticide spraying campaign, though the effects were lower than predicted due to unexpected incipient or moderate pyrethroid resistance. Increased awareness and diagnosis of vector control failures in the Gran Chaco, including appropriate remedial actions, are greatly needed.

Triatoma infestans

Triatoma

10.1186/s13071-021-04942-9

Cite

Citations (17)

Additional file 4 of Improved vector control of Triatoma infestans limited by emerging pyrethroid resistance across an urban-to-rural gradient in the Argentine Chaco

Figshare (2021)

María Sol Gaspe Marta Victoria Cardinal María del Pilar Fernández Claudia Vassena Pablo Luis Santo‐Orihuela

Additional file 4: Table S2. Block-level data including entomological variables and pyrethroid spraying during the follow-up, Avia Terai, 2015–2018.

Triatoma infestans

10.6084/m9.figshare.16529913

Cite

Citations (0)

CHAGAS DISEASE IN IMMUNOCOMPROMISED PEDIATRIC PATIENTS

Pediatric Research (1990)

Héctor Freilij Roberto Debbag Rosa Bologna M F Sackman

Etiology

Chagas Disease

Nifurtimox

10.1203/00006450-199011000-00052

Cite

Citations (0)

Laboratory diagnosis of Trypanosoma cruzi infection: a narrative review

Frontiers in Parasitology (2023)

Constanza Lopez-Albízu Rocío Rivero Griselda Ballering Héctor Freilij María Soledad Santini

Trypanosoma cruzi infection, currently endemic in 21 countries, is a public health problem not only in the Americas but also in countries with Latin American migrants. However, it is estimated that two-thirds of people with Chagas disease currently live in urban areas and that only 10% of them are aware of it. This review summarizes the most important aspects of the diagnosis of human T. cruzi infection by describing the following aspects of clinical laboratory diagnosis: the most widely used tests available in Latin America and those expected to improve access to diagnosis of the affected population with their implementation; the advantages, disadvantages, and sensitivity of the tests in the different phases of infection; and their usefulness in the acute or chronic phases of infection and in the context of immunosuppression. In this way, we hope to contribute to broadening the knowledge about this prevalent infection in the Americas.

Chagas Disease

Immunosuppression

10.3389/fpara.2023.1138375

Cite

Citations (9)

Two brothers with Martsolf's syndrome.

Journal of Medical Genetics (1985)

Juan M. Sánchez Cristina Barreiro Héctor Freilij

Two brothers affected by a syndrome consisting of short stature, hypogonadism, and severe mental retardation are reported. The syndrome shares the features of that described by Martsolf et al in two brothers born to a consanguineous Polish Jewish couple. Although our patients9 parents are Sephardic Jews, they deny consanguinity. These observations and personal knowledge of another affected Jewish boy raise the question of whether Martsolf9s syndrome is a new entity that should be included in the group of those that affect mainly Jewish people, and whether its pattern of inheritance is X linked recessive or autosomal recessive limited to males.

10.1136/jmg.22.4.308

Cite

Citations (22)

Consenso argentino de toxoplasmosis congénita

Ricardo Durlach Federico Kaufer Liliana Carral Cristina Freuler Mariana Ceriotto

La transmision de la infeccion por Toxoplasma gondii de la madre al hijo ocurre cuando la madre se infecta por primera vez en el transcurso del embarazo. Tanto el diagnostico prenatal, como el del primer ano de vida se basa en pruebas serologicas; y la mayoria de las veces es necesario realizar mas de una de estas pruebas ya que tienen distintos porcentajes de sensibilidad y/o especificidad asi como distintos niveles de complejidad. El recien nacido requiere seguimiento serologico en el primer ano de vida o hasta que se descarte el diagnostico de toxoplasmosis congenita. El diagnostico temprano de la infeccion, en la mujer embarazada, permite un tratamiento oportuno y se indica con el proposito de reducir la tasa de transmision y el dano congenito. Es posible que con un programa activo, de prevencion y tratamiento temprano, se pueda reducir la tasa de incidencia de la toxoplasmosis congenita de alrededor del 5 por mil nacimientos a 0.5 por mil. El objetivo de este consenso fue revisar la literatura cientifica para la prevencion, el diagnostico y el tratamiento de la toxoplasmosis congenita, para que se pueda implementar en nuestro pais.

Congenital toxoplasmosis

Cite

Citations (23)

Perinatal human immunodeficiency virus infection and congenital Chagas' disease.

PubMed (1995)

Héctor Freilij Jaime Altcheh G Muchinik

Chagas Disease

Source

Cite

Citations (47)

Lineamientos básicos del tratamiento etiológico de enfermedad de Chagas

Sérgio Sosa Estani Jaime Altcheh Adelina Riarte Héctor Freilij Marisa Fernández

Cite

Citations (2)

Urbanization of congenital transmission of Trypanosoma cruzi: prospective polymerase chain reaction study in pregnancy

Transactions of the Royal Society of Tropical Medicine and Hygiene (2011)

Margarita Bisio María Elena Seidenstein Juan M. Burgos Griselda Ballering Marikena G. Risso

Chagas disease ranks among the world's most neglected tropical diseases and congenital transmission is increasingly responsible for urbanization of Chagas disease in non-endemic areas. Molecular assays for amplification and profiling of parasite minicircle DNA (kDNA) and identification of discrete typing units (DTUs) were prospectively conducted in bloodstream and placental samples from pregnant women cursing chronic Chagas disease residing in Buenos Aires city. Sensitivity of kDNA-PCR increased from 75.6% to 95.6% when one to three sequential blood samples were analysed. Congenital infection (CI) was diagnosed in 3 neonates born to kDNA-PCR positive mothers, one who had transmitted CI in a previous gestation, pointing to family clustering of congenital transmission. Fourteen of 44 placental samples were kDNA-PCR positive, all from non-CI transmitting women, indicating that placental PCR is not useful for CI diagnosis. Placental PCR positivity was not related to maternal bloodstream PCR positivity and placental parasitic subpopulations not observed in bloodstream were detected by minicircle signatures. PCR targeted to intergenic regions of spliced-leader genes and serological tests using trypomastigote small surface recombinant antigens showed predominance of DTU group TcII/V/VI and only one patient infected with TcI. To our knowledge, this is the first PCR-based follow-up study of bloodstream and placental T. cruzi infections during pregnancy, including identification of DTUs. kDNA-PCR assays in serial blood samples provided high sensitivity for detection of T. cruzi DNA in pregnant women with chronic Chagas disease.

Chagas Disease

Minicircle

10.1016/j.trstmh.2011.07.003

Cite

Citations (43)