N Chenari

Shiraz University of Medical Sciences

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Abbas Ghaderi

Shiraz University of Medical Sciences

Mahboobeh Razmkhah

Shiraz University of Medical Sciences

Zahra Faghih

Shiraz University of Medical Sciences

Mousa Taghipour

Shiraz University of Medical Sciences

Fatemeh Sadat Toghraie

Shiraz University of Medical Sciences

Farin Kiany

Ahvaz Jundishapur University of Medical Sciences

Hamid Ghaderi

The University of Texas Southwestern Medical Center

Mohammad Ali Gholipour

University of Tehran

Ali Mehrafshan

Qom University of Medical Science and Health Services

Seifollah Dehghani Nazhvani

Shiraz University

Cooperative Institutions

Shiraz University of Medical Sciences

Shiraz University

Indiana University School of Medicine

Tabriz University of Medical Sciences

Khalili Hospital

Stem Cell Technology Research Center

Guilan University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Royan Institute

University of Glasgow

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Differentiation of adipose-derived stem cells into ear auricle cartilage in rabbits

The Journal of Laryngology & Otology (2012)

H Bahrani Mahboobeh Razmkhah Mohammad Javad Ashraf Nader Tanideh N Chenari

Adipose-derived stem cells have been reported as a novel candidate for the repair of cartilage injuries in vivo.In order to assess their differentiation ability, adipose-derived stem cells isolated from rabbit fat tissue were injected into the midportion of a surgically created rabbit ear auricle cartilage defect. After several months, the auricles were resected, histopathologically assessed and compared with a control group.Histopathological examination of auricles removed three, four and five months after injection showed islands of new cartilage formation at the site of the surgically induced defect. Six months after injection, we observed well-formed, mature cartilaginous plates that completely filled the defect in the native cartilage. In the control group, there was no significant growth of new cartilage.The results of this study suggest the great potential of adipose-derived stem cells to repair damaged cartilage tissue in vivo.

Auricle

10.1017/s0022215112001065

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Citations (44)

MYRICETIN: AS A THERAPEUTIC INTERVENTION FOR MENINGIOMA; POSTER PRESENTATION

Mahboobeh Razmkhah N Chenari Mousa Taghipour M Sharifirad Arman Ghaderi

Presentation (obstetrics)

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ADIPOSE - TISSUE DERIVED MESENCHYMAL STEM CELL (ASC) AS ALTERNATIVE SOURCE FOR AUTOLOGOUS CELL THERAPY

Mahboobeh Razmkhah N Chenari Zahra Faghih Behzad Khalatbari H Nemati

Cell therapy

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Sorption determination of hollow VLC resin obturators

Journal of Dentistry (1991)

Hamid Ghaderi Mahboobeh Razmkhah Farin Kiany N Chenari Mohammad Reza Haghshenas

Acrylic resin

10.1016/0300-5712(91)90107-a

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Scaffold-free adipose-derived stem cells (ASCs) improve experimentally induced osteoarthritis in rabbits.

PubMed (2012)

Fatemeh Sadat Toghraie Mahboobeh Razmkhah Mohammad Ali Gholipour Zahra Faghih N Chenari

Osteoarthritis (OA) is the most common form of arthritis seen clinically. Current treatments for OA are limited to decreasing associated pain, maintaining or improving joint function, and minimizing disability. However, these treatments have no effect on the regeneration of hyaline cartilage. Since mesenchymal stem cells (MSCs) have been described as promising cell sources for cartilage repair, the present study was designed to examine whether intra-articular injection of scaffold-free adipose-derived stem cells (ASCs) obtained from subcutaneous adipose tissue could restore the matrix of arthritic knee joints in mature animals.OA was induced in adult white New Zealand rabbits by unilateral anterior cruciate ligament transection (ACLT); the contralateral knee was considered the sham-operated group. At 12 weeks following surgery, the ASCs treated group was injected intra-articularly with a single dose of 1 × 10(6) cells suspended in 1 mL of medium. The control group received 1 mL of medium without cells and the sham-operated group received no treatment. All rabbits were sacrificed at 16 and 20 weeks after surgery. OA progression was evaluated radiologically, grossly, and histologically using hematoxylin and eosin, Safranin-O, and toluidine blue staining.At 12 weeks after surgery all knees subjected to ACLT showed radiological signs of OA. The findings showed significant differences in the quality of cartilage between ASCs-injected group compared to control group, particularly at 20 weeks after surgery.This study suggests that ASCs obtained from subcutaneous adipose tissue could be a viable approach for treating OA.

Hyaline cartilage

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INVESTIGATION OF SIMVASTATIN EFFECTS ON DIFFERENTIATION OF PERIODONTAL LIGAMENT CELLS (PDLS) TO CEMENTOBLASTS; POSTER PRESENTATION

Mahboobeh Razmkhah H Khosropanah Z Emami N Chenari Abbas Ghaderi

Cementoblast

Periodontal fiber

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POSTER PRESENTATIONS; ISOLATION OF CD133 POSITIVE STEM CELLS FROM MENINGIOMA BRAIN TUMOR TISSUES

N Chenari Ali Mehrafshan Mousa Taghipour Mehdi Rasouli Abbas Ghaderi

Isolation

Brain tumor

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Expression of Chemokines and Chemokine Receptors in Brain Tumor Tissue Derived Cells

Asian Pacific Journal of Cancer Prevention (2014)

Mahboobeh Razmkhah Fahimeh Arabpour Mousa Taghipour Ali Mehrafshan N Chenari

Chemokine and chemokine receptor expression by tumor cells contributes to tumor growth and angiogenesis and thus these factors may be considered as tumor markers. Here we aimed to characterize cells directly extracted from glioma, meningioma, and secondary brain tumors as well as non-tumoral cells in vitro. Cells were isolated from brain tissues using 0.2% collagenase and characterized by flow cytometry. Expression of SDF-1, CXCR4, CXCR7, RANTES, CCR5, MCP-1 and IP-10 was defined using flow cytometry and qRT-PCR methods. Brain tissue isolated cells were observed as spindle-shaped cell populations. No significant differences were observed for expression of SDF-1, CXCR4, CXCR7, RANTES, CCR5, and IP-10 transcripts. However, the expression of CXCR4 was approximately 13-fold and 110-fold higher than its counterpart, CXCR7, in meningioma and glioma cells, respectively. CXCR7 was not detectable in secondary tumors but CXCR4 was expressed. In non tumoral cells, CXCR7 had 1.3-fold higher mRNA expression than CXCR4. Flow cytometry analyses of RANTES, MCP-1, IP-10, CCR5 and CXCR4 expression showed no significant difference between low and high grade gliomas. Differential expression of CXCR4 and CXCR7 in brain tumors derived cells compared to non-tumoral samples may have crucial impacts on therapeutic interventions targeting the SDF-1/CXCR4/CXCR7 axis.

CCR1

CC chemokine receptors

CCL13

CCR10

CCR3

CCL21

10.7314/apjcp.2014.15.17.7201

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mRNA expression of pattern recognition receptors and their signaling mediators in healthy and diseased gingival tissues

Journal of Indian Society of Periodontology (2014)

Abbas Ghaderi Hamid Ghaderi Farin Kiany Mahboobeh Razmkhah Somayeh Dadras

Gingivitis and periodontitis are initiated by inflammation caused by microorganisms. Pathogen-associated molecular patterns (PAMPs) from these microorganisms are recognized through various toll-like receptors (TLRs) and NOD-like receptors (NLRs). In this study, we have chosen five TLRs and two NLRs as representatives taking part in the recognition and inflammation process, along with a few of their signaling mediators including CD14, MYD88, and TRIF to compare their mRNA expression levels between healthy and diseased gingival tissues. This will provide deeper insight into the mechanisms underlying gingivitis and periodontitis. Understanding the mechanisms involved in the onset and progression of the periodontal diseases could greatly help in establishing effective ways for prevention and treatment of these diseases besides decreasing the risk factor for relevant systemic disorders.Gingival tissue samples for mRNA extraction and cDNA synthesis were taken from patients with gingivitis and periodontitis and from healthy control subjects. Messenger RNA expression of all genes was assessed using real-time polymerase chain reaction (PCR).Among the genes studied in different groups, only MYD88 mRNA expression was significantly higher in the periodontitis group compared to that of the controls. The expression level of this molecule was also significantly higher in patients with severe periodontitis compared to other patients and also compared to healthy individuals. In different tissues, positive significant correlations were observed between the mRNA expression levels of some genes.Elevated mRNA levels of MYD88 in periodontitis might have a key role in the pathogenesis of this disease. Therefore, MYD88 may be a useful target for the therapy of this disease.

Pathogenesis

10.4103/0972-124x.131309

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Citations (12)

Treatment of osteoarthritis with infrapatellar fat pad derived mesenchymal stem cells in Rabbit

The Knee (2010)

Fatemeh Sadat Toghraie N Chenari Mohammad Ali Gholipour Zahra Faghih Simin Torabinejad

Infrapatellar fat pad

Chondrogenesis

10.1016/j.knee.2010.03.001

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Citations (153)