Maha A. El-Gayyar

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Evaluation of chitosan impregnated with silver nanoparticles in the treatment of chronic venous leg ulcer: An open-label controlled study

Clinical Dermatology Review (2019)

Maha A. El-Gayyar Ahmed Abdelmoneim Khalid Mowafy Moustafa A. Elsaied Mqdad Hasan Faqe

Background: The treatment of chronic venous leg ulcer (CVLU) is a major challenge. Much scientific advancement was made. Chitosan, derived from N-deacetylation of chitin, has been successfully used to promote wound healing. Silver nanoparticles (AgNPs) are used as bactericides. The aim of this work is to evaluate the efficacy and safety of chitosan alone or that impregnated with AgNPs compared to traditional compression bandage dressing in the treatment of CVLU. Materials and Methods: Thirty-eight CVLU patients completed the treatment for 3 months. They were treated with compression bandage and categorized into three groups: Group A included 12 patients used chitosan impregnated with the AgNPs, Group B included 11 patients used chitosan alone, and Group C included 15 patients used compression bandage alone. For all patients, routine investigations, lower limbs Duplex ultrasound and bacterial culture and sensitivity from the ulcers before and after treatment were done. Results: The healing of ulcers in the treated groups was mostly apparent in Groups A and C. Conclusions: Chitosan impregnated with AgNPs can be a hopeful treatment for CVLU. However, compression bandage alone is also effective for the treatment of CVLU.

Compression Bandage

Compression Therapy

10.4103/cdr.cdr_11_18

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Impact Of Helicobacter Pylori In Hyperemesis Gravidarum Associated With Rosacea.

Mansoura Nursing Journal (2014)

M Emam Maha A. El-Gayyar S. A. Agha

Background: Helicobacter pylori (H.pylori) infection is common in Egypt.It is implicated in causation of both hyperemesis gravidarum (H.G) and rosacea (chronic skin disease).It is diagnosed by positive serum IgG antibodies.Objective: is to detect any possible relationship between infection with H.pylori and (H.G) when associated with rosacea.Design: prospective controlled study.Setting: Ob. & Gyn., dermatology and clinical pathology departments, Mansoura Faculty of Medicine, Egypt.Subjects : 266 non obese women, singleton pregnancy, divided into three groups; group (I): H.G without rosacea (n=108), group (II): H.G with rosacea (n=46) and group (III), 112 pregnant women without H.G or rosacea.Results: No statistically significant difference (P>0.05)regarding age, gravidity, gestational age and Body mass index between three groups.Regarding the positive cases, from the qualitative and the quantitative point of view, IgG antibodies (group II versus III) showed extremely significance (P = 0.001), while group I versus II and I versus III showed significant difference (P = 0.019 & 0.021) respectively.Erythematous lesions of rosacea showed the most prevalent and significant skin lesion compared to papules and pustules (P = 0.14 and 0.15) respectively.Conclusions and recommendations: H.pylori infection is sugegsted to be one of the important factors in the pathogenesis of (H.G).When rosacea is associated with (H.G), the obstetrician should expect that H.pylori is often the culprit responsible for the pathogenesis of both.We recommended more studies to clarify the different non teratogenic drugs which can be used for eradication of H.pylori during the period of organogenesis.Hence a specific and a causative treatment of H.G. will be elicited.

Pathogenesis

Hyperemesis gravidarum

10.21608/mnj.2014.148992

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Evaluation of Therapeutic Effects of Aloe Vera: Coal Tar Mixture in Psoriasis: An Immunohistochemical Study

Asian Journal of Dermatology (2012)

Maha A. El-Gayyar Amany A. El‐Hawwary Nagwa I. Bakre

Aloe Vera

Coal tar

tar (computing)

10.3923/ajd.2012.16.28

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Langerhans Cell Histiocytosis: Clinical, Histopathological and Radiological Case Series Study: An Institutional Experience

Maha A. El-Gayyar Manar Sallam M. Ben Khaled Mohamed El-Mougy Amany A. El‐Hawwary

Langerhans Cell Histiocytosis

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New Methodology for Achieving Trim Condition for a small Flapping Wing Air Vehicle

Bulletin of the Faculty of Engineering Mansoura University (2020)

Mohammed Fanni Maha A. El-Gayyar Ahmed Sameh

When dealing with a conventional aircraft, the design must be based on simplification assumptions, such as a cruising flight or a trimmed flight condition, which requires aircraft to have forces and moments equilibrium with respect to the center of gravity without any continuous control efforts.However, in case of ornithopters, there is no such equilibrium point due to the continuous flapping wing motion during the cruising flight.Therefore, this paper introduces a new methodology to obtain trimmed flight condition for a small flapping wing air vehicle.This methodology is based on applying initial impulsive forces to the air vehicle in such a way that the flapping wing air vehicle reaches almost constant flight speed after removing the initial impulsive forces.This enables the designer to examine the design parameters of the vehicle during realistic flight performance.A refined aerodynamic model programmed with MATLAB ® is integrated into a flapping vehicle model using efficient multi body dynamics software MSC.ADAMS ® to test the system.The results show perfect trimmed flight condition for a flapping wing air vehicle that never presented before in the literature.

Trim

Flapping

Micro air vehicle

10.21608/bfemu.2020.100784

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IL-13 gene expression in patients with atopic dermatitis: relation to IgE level and to disease severity.

PubMed (2004)

Shereen S Metwally Youssef M. Mosaad Elham R Abdel-Samee Maha A. El-Gayyar Abeer Abdelaziz

Atopic dermatitis (AD) is a chronic inflammatory skin disease frequently associated with an increased serum IgE level. T helper cells are thought to play an important role in the pathogenesis of AD. It is commonly believed that allergens activate Th2 cells, and it is likely that the cytokines produced by Th2 cells are crucial factors in the induction and maintenance of the disease. IL-13 is one of the cytokines that are produced by Th2 lymphocytes and, like IL-4, it can induce the production of IgE. In order to evaluate its role in the pathogenesis of AD, IL-13 mRNA expression was studied in peripheral blood of patients with different degrees of AD and compared with healthy subjects. Also, we correlated its level of expression with the level of serum IgE and with the severity of the disease. EDTA blood was obtained from 25 patients (divided into three groups ranged from mild to severe AD) and 12 normal subjects as a control group. We examined the blood sample for IL-13 mRNA expression using RNA extraction technique, RT-PCR, PCR amplification using primers specific for IL-13 and beta- actin (as internal control) this is followed by visualization of the expressed bands using gel electrophoresis and DNA marker. Serum IgE level was detected using an ELISA kit. Our results revealed that, IL-13 mRNA is significantly expressed in patients with AD as compared to normal control (P<0.001). IL-13 mRNA shows higher level of expression in severe AD group in comparison with both moderate and mild groups (P = 0.05). Serum levels of IgE showed highly significant increase in patients with AD as compared with the control group (p=0.019), its level is significantly higher in severe AD group versus moderate and mild AD groups (P=0.009 and 0.022, respectively). There is a highly significant positive correlation between serum levels of IgE and the levels of IL-13 mRNA expression in all AD groups (P=0.001). In conclusion, the high level of IL-18 mRNA expression in AD, and its correlation with serum level of IgE and with severity of disease indicates that IL-13 is involved in the pathogenesis of the disease and is an important in vivo IgE inducer.

Pathogenesis

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Citations (24)