OBJECTIVE: To evaluate the therapeutic efficiency of compound Radix sophorae flavescentis injection in the chemotherapy of malignant tumor.METHODS:100 cases with malignant tumor were divided in to two Groups,50 patients of test group were treated with chemotherapy,and the same time using radix sophorae flavescentis injection,and 50 patients of control group only received chemotherapy.RESULTS: The incidence rates of nausea,vomit and hepaticin jury in test group were lower than control group(P0.05),and the incidence rates of oral cavity inflammation and diarrhea were lower than control group(P0.05).The change of WBC in test group after chemotherapy was not apparent but the WBC reduced apparently in control group(P0.05).CONCLUSIONS: The application of compound radix sophorae flavescentis injection in chemotherapy can decrease the incidence rates of the side effect of chemotherapy apparently,increase the patients' tolerance to chemotherapy,and improve the patients' quality of life.
Objective To investigate the effect of TNF-α on production of nitric oxide (NO) and activity of nitric oxide synthase(eNOS) in human umbilical vein endothelial cells(HUVECs). Methods HUVECs were incubated with TNF-α at different concentrations (2-20ng/ml) and different times(2-48h) or pretreatment with L-NMMA or DXM. Nitric oxide production and activity of nitric oxide synthase in HUVECs were measured by NO and NOS assay kits. Results (1) Activity of eNOS was down-regulated by TNF-α in a concentration-dependent manner, while production of NO was upregulated. (2) The activity of eNOS attenuated after long-time treatment with TNF-α, but marked increased production of NO was detected after 24h. (3) The induction of NO by TNF-α can be inhibited by L-NMMA and DXM. Conclusion TNF-α can reduce activity of eNOS and induce iNOS, so that production of NO is increased.
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