Hwan Mook Kim

Gachon University

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Sang‐Bae Han

Chungbuk National University

Jong Soon Kang

Korea Research Institute of Bioscience and Biotechnology

Song‐Kyu Park

Korea University

Gyoonhee Han

Yonsei University

Kiho Lee

Kyung Hee University

Kiho Lee

University of Missouri

Keun‐Yeong Jeong

Naver (South Korea)

Yeo Dae Yoon

Korea Research Institute of Bioscience and Biotechnology

Song-Kyu Park

Korea University

Won Kee Yoon

Korea Research Institute of Bioscience and Biotechnology

Cooperative Institutions

Korea Research Institute of Bioscience and Biotechnology

154

Seoul National University

Korea University

Yonsei University

Chungnam National University

Chungbuk National University

Korea Advanced Institute of Science and Technology

Sungkyunkwan University

Korea University of Science and Technology

University of Ulsan

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Improvement of high-fat diet-induced obesity by a mixture of red grape extract, soy isoflavone and l-carnitine: Implications in cardiovascular and non-alcoholic fatty liver diseases

Food and Chemical Toxicology (2011)

Jong Soon Kang Won Kyung Lee Chang Woo Lee Won Kee Yoon Nayang Kim

Transaminase

10.1016/j.fct.2011.06.071

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Citations (42)

Antagonistic effects of interferons(IFNs) and sodium orthovanadate on responses produced by TCDD in several culture systems

Toxicological Research (1991)

Hwan Mook Kim

Sodium orthovanadate

Mixed Function Oxidase

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Citations (0)

NSC126188, a piperazine alkyl derivative, induces apoptosis via upregulation of RhoB in HeLa cells

Investigational New Drugs (2010)

Bo‐Kyung Kim Dong‐Myung Kim Kyung‐Sook Chung Song-Kyu Park Shin-Jung Choi

RHOB

HeLa

10.1007/s10637-010-9433-3

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Citations (10)

Midazolam Induces Cellular Apoptosis in Human Cancer Cells and Inhibits Tumor Growth in Xenograft Mice

Molecules and Cells (2013)

Siddhartha Kumar Mishra Ju‐Hee Kang Chang Woo Lee Seung Hyun Oh Junsun Ryu

Midazolam

K562 cells

Growth inhibition

10.1007/s10059-013-0050-9

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Citations (34)

Preliminary report Antitumor activity of cytokine-induced killer cells against human lung cancer

Hwan Mook Kim Jaeseung Lim Song‐Kyu Park Jong Soon Kang Kiho Lee

Lung cancer is the leading cause of cancer-related death among men and women in the world. Despite the aggressive treatment with surgery, radiation and chemotherapy, the long term survival for lung cancer patients remains low. In this study, the anti-tumor activity of cytokine-induced killer (CIK) cells against human lung cancer was evaluated in vitro and in vivo. Although CD3 +CD56 + CIK cells were rare in fresh human peripheral blood mononuclear cells, they could expand more than 1000-fold on day 14 in the presence of anti-CD3 antibody plus IL-2. At an effector-target cell ratio of 30:1, CIK cells destroyed 98% of NCI-H460 human lung cancer cells, which was determined by the 51 Cr-release assay. In addition, CIK cells at doses of 3 and 30 million cells per mouse inhibited 57% and 77% of NCI-H460 tumor growth in nude mouse xenograft assay, respectively. This study suggests that CD3 + CD56 + CIK cells may be used as an adoptive immunotherapy for patients with lung cancer.

Cytokine-induced killer cell

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Histamine receptor 2-mediated growth-differentiation factor-15 expression is involved in histamine-induced melanogenesis

The International Journal of Biochemistry & Cell Biology (2012)

Hye Ja Lee Mi Kyung Park Eun Ji Lee You Lee Kim Hyun Ji Kim

Histamine H4 receptor

10.1016/j.biocel.2012.08.020

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Citations (23)

Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai

Immunopharmacology (1998)

Sang‐Bae Han Young Hee Kim Chang Woo Lee Sun Mi Park Hae‐Young Lee

Lentinan

10.1016/s0162-3109(98)00026-5

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Citations (163)

Lipid‐soluble extract of Red Ginseng inhibits the growth of lung cancer cells through induction of apoptosis and cell cycle arrest

The FASEB Journal (2010)

Moo Rim Kang Sung Kyu Park Hwan Mook Kim Chang Woo Lee Dong Chung Kim

It is known that red ginseng has a lot of biological activities, including anti‐tumor activity. In this study we investigated the anticancer activity of lipid‐soluble ginseng extract (HRE) prepared by n‐hexane extraction. The inhibitory activity of HRE on the growth of NCI‐H460 human lung cancer cells was evaluated by the sulforhodamine B assay. The effect of HRE on apoptosis and cell cycle was also analyzed. HRE exhibited a potent antiproliferative effect against the NCI‐H460 cells and induced G0/G1 cell cycle arrest. The percentage of G0/G1 increased from 54.5 to 74.0%, but S phase decreased from 42.1 to 17.2%. HRE effectively reduced the level of cell cycle mediators, such as CDK,2, CDK4, CDK6, cyclin D3 and cyclin E, at the concentration of 100 ug/ml. In addition, HRE also induced apoptosis in these cells, which was accompanied by the activation of caspases, including caspase‐9, caspase‐8 and caspase‐3. The pan‐caspase inhibitor, Z‐VAD‐fmk, partially blocked the cell death induced by HRE. Our results indicate that HRE exerts an anti‐proliferative activity against lung cancer cells by perturbing the cell cycle and activating the caspase pathways.

Cyclin-dependent kinase 6

10.1096/fasebj.24.1_supplement.lb500

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A Combination of Grape Extract, Green Tea Extract and l‐Carnitine Improves High‐fat Diet‐induced Obesity, Hyperlipidemia and Non‐alcoholic Fatty Liver Disease in Mice

Phytotherapy Research (2011)

Jong Soon Kang Won Kyung Lee Won Kee Yoon Nayang Kim S. Y. Park

To develop a therapeutic agent for obesity‐related metabolic disorders, a mixture of dietary components was prepared, including grape extract, green tea extract and l ‐carnitine (RGTC), and its effects on obesity, hyperlipidemia and non‐alcoholic fatty liver disease examined. The RGTC dramatically inhibited the high‐fat diet (HFD)‐induced increase in body weight and fat in C57BL/6 mice, whereas food consumption was not affected by RGTC treatment. The RGTC also concentration‐dependently suppressed the HFD‐induced increase in plasma lipids, such as low‐density lipoprotein cholesterol and triglycerides. In addition, increases in liver weight and liver steatosis were returned to normal by RGTC treatment in HFD‐fed C57BL/6 mice. The plasma levels of glutamic‐oxaloacetic transaminase and glutamic‐pyruvic transaminase were also significantly down‐regulated by RGTC treatment. These results suggest that RGTC suppressed HFD‐induced obesity, hyperlipidemia and non‐alcoholic fatty liver disease, suggesting that RGTC supplementation might be a promising adjuvant therapy for the treatment of these metabolic disorders. Copyright © 2011 John Wiley & Sons, Ltd.

Hyperlipidemia

Steatosis

Transaminase

10.1002/ptr.3476

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Citations (21)

Inhibition of bone marrow-derived dendritic cell maturation by glabridin

International Immunopharmacology (2010)

Jee Youn Kim Jong Soon Kang Hwan Mook Kim Hwa Sun Ryu Hyung Sook Kim

CD86

CD80

Zymosan

IκBα

10.1016/j.intimp.2010.06.025

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Citations (44)