Yang Song

Shanghai Jiao Tong University

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Tuomas P. J. Knowles

University of Cambridge

Ho Cheung Shum

University of Hong Kong

Ulyana Shimanovich

Weizmann Institute of Science

Jingmei Li

National University Health System

Anke Zhang

Second Affiliated Hospital of Zhejiang University

Thomas C. T. Michaels

ETH Zurich

Yuyuan Xue

Taiyuan University of Technology

Lori Avery

UConn Health

Jie Yang

Peking University

Shengren Li

Taiyuan University of Technology

Cooperative Institutions

Beijing University of Chinese Medicine

Shanghai Jiao Tong University

Chinese Academy of Medical Sciences & Peking Union Medical College

University of Cambridge

University of Connecticut

Tsinghua University

Peking University

Dalian University of Technology

Chinese Academy of Sciences

National University of Singapore

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UV‐Induced Oxidation Preparation of Multi‐Functional Lignin‐Based AgNPs and its Application for Conductive Coating, Antibacterial Enhancement, and Product Separation

ChemistrySelect (2024)

Yang Song Shengren Li Yuyuan Xue

Abstract This study presents a novel approach for regulating the properties of lignin‐based silver nanoparticles (AgNPs), which was UV‐induced Tetrahydrofuran (THF) to form peroxide for the etching of these nanoparticles. The lignin coating was first degraded by oxidation, and the properties of the exposed AgNPs changed under etching. Notably, water can greatly regulate the oxidation capacity of the THF medium, thereby controlling the degradation degree of lignin coating and obtaining dissolution, aggregation, precipitation, and color‐variable phenomena of AgNPs under the synergistic effect of UV irradiation and peroxide etching. By adjusting UV irradiation time, various functional products of silver nanowires (AgNWs), color‐variable AgNPs, lignin‐based AgNPs aggregates, and composite solution of Ag particles and Ag + were obtained. The transformation of these product properties is closely related to the oxidation capacity of H 2 O/THF medium. In addition, Multi‐functional Lignin‐based AgNPs show excellent application potential in conductive coating, antibacterial enhancement, and product separation, providing a promising avenue for the targeted utilization of lignin‐based AgNPs.

Silver nanoparticle

10.1002/slct.202400300

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A point-of-care microfluidic biosensing system for rapid and ultrasensitive nucleic acid detection from clinical samples

Lab on a Chip (2023)

Yuxuan Zhang Yang Song Zhengyan Weng Jie Yang Lori Avery

A point-of-care microfluidic device takes unprocessed clinical samples, actively lyses viral RNAs, and performs the target amplification-free nucleic acid detection with a limit of detection down to 10 aM with 25 min sample-to-result time.

Point of care

Point-of-Care Testing

Nucleic acid detection

Nucleic acid quantitation

10.1039/d3lc00372h

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Citations (7)

Effect of Ultrasonic and Alkylation Method on Emulsifying Stability of Soybean Protein Isolate

Zhongguo Shipin Xuebao (2016)

Yang Song Xiuqing Zhu Haibo Wu Xu Hui Zhao Caihong

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Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces

Nature Communications (2016)

Yang Song Ulyana Shimanovich Thomas C. T. Michaels Qingming Ma Jingmei Li

Abstract All-aqueous emulsions exploit spontaneous liquid–liquid separation and due to their water-based nature are particular advantageous for the biocompatible storage and processing of biomacromolecules. However, the ultralow interfacial tensions characteristic of all-aqueous interfaces represent an inherent limitation to the use of thermally adsorbed particles to achieve emulsion stability. Here, we use protein nanofibrils to generate colloidosome-like two-dimensional crosslinked networks of nanostructures templated by all-aqueous emulsions, which we term fibrillosomes. We show that this approach not only allows us to operate below the thermal limit at ultra-low surface tensions but also yields structures that are stable even in the complete absence of an interface. Moreover, we show that the growth and multilayer deposition of fibrils allows us to control the thickness of the capsule shells. These results open up the possibility of stabilizing aqueous two-phase systems using natural proteins, and creating self-standing protein capsules without the requirement for three-phase emulsions or water/oil interfaces.

Aqueous two-phase system

Thermal Stability

Emulsified fuel

10.1038/ncomms12934

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Citations (149)

Corrosion barriers induced by nano-heterogeneous structure in a biodegradable Mg Zn-based metal

Journal of Magnesium and Alloys (2024)

Xinbao Kang Anke Zhang Xiyue Zhang Yu Han Yuhui Zhang

Due to its excellent biocompatibility and biodegradability, Mg has received widespread attention in biomaterials as implants and even bio-batteries. However, the poor corrosion resistance makes it difficult to meet the growing demand for implant materials. This study developed a biodegradable nano-heterogeneous Mg(48 wt%)Zn(52 wt%)-based metal (NHMZ) comprising nanocrystalline matrix phase Mg51Zn20 and nanoscale MgZn2 precipitates. The unique microstructure of NHMZ enhances its corrosion resistance. The spherical aberration-corrected transmission electron microscope (AC-TEM) and precession electron diffraction (PED) characterized the microstructures. The corrosion rate of NHMZ is about 0.21 mm y−1 after soaking for 4 weeks, approximately 58 % of high pure Mg. In addition, the anode discharge of NHMZ is more stable than Mg, indicating it has great potential in biological batteries. This work hopes to broaden the development direction of biodegradable metallic materials and break through the performance limitation of current biodegradable Mg alloys.

Nanocrystalline material

Biocompatibility

10.1016/j.jma.2024.04.032

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Baicalein-modified chitosan nanofiber membranes with antioxidant and antibacterial activities for chronic wound healing

International Journal of Biological Macromolecules (2024)

Yang Song Ning Han Zishuo Guo Huahua Li Mingxue Guo

Baicalein

Electrospinning

Wound dressing

10.1016/j.ijbiomac.2024.134902

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Citations (1)

Liquid–liquid phase separation-inspired design of biomaterials

Biomaterials Science (2024)

Yang Song

Liquid-liquid phase separation (LLPS) is a crucial biological process that governs biomolecular condensation, assembly, and functionality within phase-separated aqueous environments. This phenomenon serves as a source of inspiration for the creation of artificial designs in both structured and functional biomaterials, presenting novel strategies for manipulating the structures of functional protein aggregates in a wide range of biomedical applications. This mini review summarizes my past research endeavors, offering a panoramic overview of LLPS-inspired biomaterials utilized in the design of structured materials, the development of cell mimetics, and the advancement of intelligent biomaterials.

Separation (statistics)

Liquid phase

10.1039/d3bm02008h

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Citations (2)

Multiphase Protein Microgels

Macromolecular Bioscience (2014)

Ulyana Shimanovich Yang Song Jasna Brujić Ho Cheung Shum Tuomas P. J. Knowles

Peptides and proteins represent attractive building blocks for the development of new functional materials due to the biocompatibility and biodegradability of many naturally abundant proteins. In nature, sophisticated material functionality is commonly achieved through spatial control of protein localisation and structure on both the nano and micro scales. We approached this requirement in an artificial setting by exploiting the propensity of proteins to self-assemble into amyloid fibrils to achieve nano scale order, and utilised aqueous liquid/liquid phase separation to control the micron scale localization of the proteinaceous component under microconfinement. We show that in combination with droplet microfluidics, this strategy allows the synthesis of core-shell microgel particles composed of protein nanofibrils.

Biocompatibility

10.1002/mabi.201400366

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Citations (34)