Yang Liu

Capital Medical University

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Xiaofei Shang

Qinghai Tibetan Hospital

Xiuhui Li

Beijing YouAn Hospital

Tengxiao Liang

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

Wei Hou

Beijing YouAn Hospital

Fangliang Xing

Beijing Intelligent Entropy Science & Technology Co. Ltd.

Lixia Dai

Ministry of Agriculture and Rural Affairs

Long‐Yu Zhang

Beijing YouAn Hospital

Jian He

Chinese Academy of Agricultural Sciences

Zhexian Cheng

Beijing Chao-Yang Hospital

Bin Cai

Peking Union Medical College Hospital

Cooperative Institutions

Capital Medical University

Beijing YouAn Hospital

Beijing Chao-Yang Hospital

Beijing Chaoyang Emergency Medical Center

Capital University

Jinan University

Guangdong Provincial People's Hospital

Lanzhou Institute of Husbandry and Pharmaceutical Sciences

Chinese Academy of Agricultural Sciences

Gansu Agricultural University

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JoVE Video Dataset

Yang Liu Tengxiao Liang Fangliang Xing Wei Hou Xiaofei Shang

Hepatic fibrosis is an early stage of liver cirrhosis, and there are no better non-invasive and convenient methods for the detection and evaluation of the disease. Despite the good progress made with the liver stiffness map (LSM) based on magnetic resonance elastography (MRE), there are still some limitations that need to be overcome, including manual focus determination, manual selection of regions of interest (ROIs), and discontinuous LSM data without structural information, which makes it impossible to evaluate the liver as a whole. In this study, we propose a novel three-dimensional (3D) digital model for the early diagnosis of hepatic fibrosis based on MRE. MRE is a non-invasive imaging technique that employs magnetic resonance imaging (MRI) to measure the liver stiffness at the scanning site through human-computer interaction. Studies have indicated a significant positive correlation between the LSM obtained through MRE and the degree of hepatic fibrosis. However, for clinical purposes, a comprehensive and precise quantification of the degree of hepatic fibrosis is necessary. To address this, the concept of Liver Stiffness Distribution (LSD) was proposed in this study, which refers to the 3D stiffness volume of each liver voxel obtained by the alignment of 3D liver tissue images and MRE indicators. This provides a more effective clinical tool for the diagnosis and treatment of hepatic fibrosis.

Magnetic Resonance Elastography

Hepatic fibrosis

Liver disease

Hepatic Diseases

10.3791/65507-v

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Three-Dimensional Heat Map: The OTA/AO Type 43C Pilon Fracture Lines Distribution

International Journal of General Medicine (2024)

Yuling Gao Yanrui Zhao Hanzhou Wang Xiaopei Xu Zhexian Cheng

Background: This study aimed to create three-dimensional heat map and study the characteristic of fracture lines and represented fragments of OTA/AO type 43C pilon fractures. Methods: CT scan was performed in105 fractures diagnosed with OTA/AO type 43C pilon fractures between January 2017 and December 2022. Three-dimensional pilon fracture maps were created and converted into fracture heat maps. CT scan graphic parameters including the fracture line height, α angle, β angle, the ratio of the area and size of bone fragment represented by the fracture line to the total articular surface were measured. Results: The study included 105 patients with 91 males and 14 females. The fractures included C1 (n=16), C2 (n=23), and C3 (n=66). There was no statistically different among the most parameters except in the fracture-line height of the anterior fracture line (p=0.03) and the sagittal fracture line (p=0.02) between C2 and C3 pilon fractures. The average size of the anterolateral fragment, occupied approximately 13.5% of the articular surface area, was (11.5± 2.8) mm × (20.5± 6.3) mm with the average height of 29.8 mm. The average size of the posterolateral fragment, occupied approximately 13.0% of the articular surface area, was (15.7± 4.6) mm × (19.3± 4.0) mm with the average height of 19.1 mm. Conclusion: This study demonstrates that the articular surface fracture lines in the C type pilon fracture are formed by fixed main fracture lines. The understand of morphological and distribution characteristics of the fracture lines and size of fragments in OTA/AO type 43C pilon fractures would help the surgeons take suitable approach and fixation. Keywords: pilon fractures, heat map, three-dimensional reconstruction, classification

Pilon fracture

Articular surface

Bone fracture

10.2147/ijgm.s444977

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Reflection and recommendation for the teaching of english as a second language under multimedia networking environment

Wenjun Lu Yang Liu

This paper reflects the rapid development of multimedia networking in the teaching of English as a foreign language (EFL) and teaching of English as a second language (ESL) in Chinese universities in recent years. Compared with the rapid development of multimedia networking in the teaching of EFL, the teaching of ESL has lagged behind in terms of the teaching methodology. The paper recommends that teachers teaching ESL should endeavor to make full of multimedia networking in their teaching in order to achieve a better teaching effect. In addition, the paper provides some concrete methods on how to advance the implementation of multimedia networking in the teaching of ESL.

Reflection

Foreign language teaching

Teaching english

10.1109/icmt.2011.6001917

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A Three-Dimensional Digital Model for Early Diagnosis of Hepatic Fibrosis Based on Magnetic Resonance Elastography

Journal of Visualized Experiments (2023)

Yang Liu Tengxiao Liang Fangliang Xing Wei Hou Xiaofei Shang

Magnetic Resonance Elastography

Hepatic fibrosis

Liver disease

10.3791/65507

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Ruangan Granules Present Anti-Liver Fibrosis Activity by Attenuating the Inflammatory Response Via PINK1/Parkin-Mediated Mitophagy

Xiaofei Shang Yang Liu Lixia Dai Qianqian Niu Huan Chen

Background: Ruangan granules (RGGs) have been used to treat liver fibrosis with good clinical efficacy for many years. The anti-liver fibrosis activity of RGGs was proven in vivo in our previous study. However, the potential mechanism against liver fibrosis is still unclear.Purpose: The effect of RGG on the inflammatory response and oxidative stress of HL-7702 cells induced by LPS and its underlying mechanisms were explored.Methods: HL-7702 cells were used to establish an LPS-induced model of liver fibrosis. HL-7702 cells’ inflammatory response and oxidative stress induced by LPS were evaluated. α-Smooth muscle actin (α-SMA) in LX-02 cells in the coculture model was detected. The effect on the PINK1-Parkin-mediated mitophagy pathway was investigated using western blotting, PCR, and other technologies in vivo and in vitro.Results: RGG inhibited the release of inflammatory cytokines and improved the oxidative stress of HL-7702 cells in a concentration-dependent manner, especially at 1000 μg/mL (p<0.01). The activation of LX-02 cells was hindered, and the release of α-SMA was inhibited. RGG improved mitochondrial morphology and function and inhibited proteins and genes overexpression related to mitophagy. PINK1-Parkin is the main pathway that mediates mitophagy and attenuates the inflammatory response, contributing to the RGG anti-liver fibrosis effect in vivo and in vitro.Conclusion: RGG exerted anti-liver fibrosis activity by attenuating the inflammatory response via PINK1/Parkin-mediated mitophagy. This study provides an overall view of the mechanism underlying the protective action of RGG against liver fibrosis.

PINK1

Inflammatory response

10.2139/ssrn.4264488

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Reconstruction of chest wall with MatrixRIB plate after sternal tumor resection in children

International Journal of Orthopaedics Sciences (2022)

Wenlin Wang Weiguang Long Yang Liu Bin Cai Juan Luo

Chest wall tumor surgery generally includes two parts, one is tumor resection the other is chest wall reconstruction. Tumor resection is relatively simple, and the focus of reconstruction surgery is the selection of materials. MatrixRIB plate is a practical reconstruction material. It can not only be used for reconstruction of ribs and costal cartilages, but also for reconstruction of sternum, so it can be used as the preferred material for reconstruction of chest wall. For the children patients, since the development of chest wall is involved, it is necessary to observe whether it affects the development of bone structure after reconstruction with MatrixRIB plate. If there is an impact, another operation is required for a new reconstruction.

Sternum

10.22271/ortho.2022.v8.i3d.3205

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Duration of SARS‐CoV‐2 RNA shedding and factors associated with prolonged viral shedding in patients with COVID‐19

Journal of Medical Virology (2020)

Tongzeng Li Zhen‐Huan Cao Yu Chen Miaotian Cai Long‐Yu Zhang

To investigate the factors associated with the duration of severe acute respiratory syndrome coronavirus 2 RNA shedding in patients with coronavirus disease 2019 (COVID-19). A retrospective cohort of COVID-19 patients admitted to a designated hospital in Beijing was analyzed to study the factors affecting the duration of viral shedding. The median duration of viral shedding was 11 days (IQR, 8-14.3 days) as measured from illness onset. Univariate regression analysis showed that disease severity, corticosteroid therapy, fever (temperature>38.5°C), and time from onset to hospitalization were associated with prolonged duration of viral shedding (P < .05). Multivariate regression analysis showed that fever (temperature>38.5°C) (OR, 5.1, 95%CI: 1.5-18.1), corticosteroid therapy (OR, 6.3, 95%CI: 1.5-27.8), and time from onset to hospitalization (OR, 1.8, 95%CI: 1.19-2.7) were associated with increased odds of prolonged duration of viral shedding. Corticosteroid treatment, fever (temperature>38.5°C), and longer time from onset to hospitalization were associated with prolonged viral shedding in COVID-19 patients.

Viral Shedding

Coronavirus

Univariate analysis

10.1002/jmv.26280

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Citations (93)

Adoption of User-Generated Content Initiatives by Media Organizations

Han Lv Zengkai Lu Yang Liu

We are in the times of "participatory media culture". This paper first examines the possibilities by news APPs providing for the user participation. We examine the UGC features presented by nine news APPs, assign variables according to its varying degrees of participation, and present the overall degree of user participation of each news APP. This study also explores the factors behind the adoption of UGC features initiatives in mainstream news organizations, discusses the reasons for the unsatisfactory conditions of user participation in mainstream media journalism practices, and tries to build a whole influencing mechanism of the adoption of UGC initiatives.

Mainstream

User-Generated Content

User Engagement

10.1109/icime.2018.00032

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Causes of physician–patient trust absence and its rebuilding from the perspective of informed consent

Zhonghua yiyuan guanli zazhi (2015)

Yang Liu Zhaofeng Lyv Xiaoyan Wang Jin Hao Jingnan Miao

Physician-patient trust is the basis of informed consent, and the informed consent institution is supposed to strengthen the trust. However, it affects trust in an opposite way in practice. This research aimed to analyze the relationship between informed consent and physician-patient trust, and provide with the advice, recommending on such rebuilding. Key words: Informed consent; Physician-patient trust; Standard of reasonable patient

Institution

10.3760/cma.j.issn.1000-6672.2015.09.012

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