Objective:Through observing the change in the level of serum estradiol(E_2),testosterone(T) and parathyroid hormone(PTH),to investigate clinical efficacy of catgut-embedding therapy in pishu and shenshu on the change of endocrine hormone of women with primary osteoporosis.Methods:Sixty women patients with primary osteoporosis were randomly assigned into acupoint catgut-embedding(n=30)group and acupuncture group(n=30),6 weeks after treatment,patients were evaluated with the level of serum estradiol(E_2),testosterone(T) and parathyroid hormone(PTH).Results:①E_2,T:Compared with baseline data,serum estradiol(E_2) and testosterone(T) of both groups after treatment are increased and significant differences were showed in both groups(P0.05).There were not significant differences between the two groups(P﹥0.05);②PTH:Compared with the data before the treatment,both groups were not significant differences after the treatment(P﹥0.05).There were not significant differences between acupoint catgut-embedding group and acupuncture group(P﹥0.05).Conclusion:Both acupuncture and acupoint catgut-embedding therapy in pishu and shenshu can make the level of serum estradiol(E_2)and testosterone(T) of women with primary osteoporosis rise after 6 weeks treatment.The level of parathyroid hormone(PTH) is not strongly influenced by the two types treatments.The mechanism of clinical efficacy of acupuncture and acupoint catgut-embedding methed in pishu and shenshu for primary osteoporosis depends on increasing the level of serum estradiol(E_2) and testosterone(T).
Objective To analysis the clinical characteristics and the long-term effect of children with acute lymphoblastic leukemia (ALL).Methods From 2005 to 2010,80 newly diagnosed ALL children were enrolled and treated with protocol based on ALL-BFM2002.The five-years overall survival (OS)and event-free survival(EFS) were analyzed by the method of Kaplan-Meier.Results For the 80 patients,male to female ratio is 1.22∶1.The median age was 4.3 years.33 were in standard risk(41.2％),37 were in medium risk(46.3％),and 10 were in high risk(12.5％).22 had white blood cell count ≥20 x 109/L(27.5％).three patients with BCR-ABL translocation(3.8％),one patient with MLL gene rearrangement(1.3％),17 patients with TEL-AML translocation (21.3％).During induction therapy,79 patients (98.8 ％) achieved complete remission(CR).The five-years OS and EFS were (85.9 ± 4.0) ％ and (79.2 ± 4.7) ％ respectively.The five-years EFS:SR group (86.6 ± 6.4) ％,IR group (81.1 ± 6.4) ％,HR group (48.0 ± 16.4) ％.The difference among risk groups was statistically significant(x2 =7.03,P ＜0.05).12 patients relapsed(15.0％),the median time from diagnosis to relapse was 23.5 months.11 patients died (13.8 ％).Conclusion According to stratification by risk factors and risk-adapted therapy,the quality of ALL children's life had improved.
Key words:
Acute, lymphoblastic, Leukemia; Children; Event-free survival
New glycosylated zein peptides (GZP) were produced by transglutaminase-induced d-glucosamine conjugation onto zein peptides. GZP's antagonistic effects on alcohol-induced liver injury in rats were evaluated. Compared with the alcohol model group, GZP (250 mg/kg·bw) remarkably increased alcohol dehydrogenase, acetaldehyde dehydrogenase, endogenous antioxidant enzymes activities, and GSH levels in liver, decreased serum triacylglycerol, tumor necrosis factor-α, liver malonaldehyde, reactive oxygen species, and lipopolysaccharide (LPS) levels, and significantly reversed pathological changes in liver tissues. These results indicate that low-dose GZP administration can alleviate alcohol-induced liver injury by accelerating alcohol metabolism, reversing hepatic redox status, and attenuating LPS-mediated inflammation responses. GZP is a potential alcohol metabolism promoter and liver-protective agent.
'/%3e%3cuse xlink:href='%23a' transform='rotate(23.036 .093 25.536)'/%3e%3cuse xlink:href='%23a' transform='rotate(45.87 1.273 16.18)'/%3e%3cuse xlink:href='%23a' transform='rotate(69.945 .996 12.078)'/%3e%3cuse xlink:href='%23a' transform='rotate(20.66 -19.689 31.932)'/%3e%3c/svg%3e)