Olivier Barthélemy

Inserm

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Gérard Helft

Sorbonne Université

Johanne Silvain

Pitié-Salpêtrière Hospital

Gilles Montalescot

Assistance Publique – Hôpitaux de Paris

Claude Le Feuvre

Sorbonne Université

Jean‐Philippe Collet

Pitié-Salpêtrière Hospital

Richard Isnard

Sorbonne Université

Mathieu Kernéis

Assistance Publique – Hôpitaux de Paris

Jean‐Sébastien Hulot

Assistance Publique – Hôpitaux de Paris

Françoise Pousset

Sorbonne Université

Cécile Ciangura

Sorbonne Université

Cooperative Institutions

Sorbonne Université

147

Assistance Publique – Hôpitaux de Paris

142

Pitié-Salpêtrière Hospital

117

Inserm

116

Fondation pour l’innovation en Cadiométabolisme et Nutrition

Université Paris Cité

Unité de recherche sur les maladies cardiovasculaires et métaboliques

Nutrition et obésité : approches systémiques

Sorbonne Paris Cité

Hôpital Charles-Foix

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Accuracy of multislice computed tomography in the preoperative assessment of coronary disease in patients scheduled for heart valve surgery

Archives of cardiovascular diseases (2012)

Réda Jakamy Olivier Barthélemy Claude Le Feuvre Emmanuel Berman Rhéda Boutekadjirt

Multislice computed tomography

Elective surgery

Multislice

Valve replacement

10.1016/j.acvd.2012.05.004

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Citations (6)

High Doses of Clopidogrel to Overcome Genetic Resistance

КАРДИОЛОГИЯ УЗБЕКИСТАНА (2011)

Jean‐Philippe Collet Jean‐Sébastien Hulot Ghalia Anzaha Ana Peña Thomas Chastre

Pharmacodynamics

Active metabolite

10.1016/j.jcin.2011.03.002

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Citations (130)

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Nature Communications (2020)

Antonio Molinaro Pierre Bel Lassen Marcus Henricsson Hao Wu Solia Adriouch

Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.

Imidazole

10.1038/s41467-020-19589-w

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Citations (176)

Myocardial ischemia: a silent epidemic in Type 2 diabetes patients

Future Cardiology (2011)

Claude Le Feuvre Sophie Jacqueminet Olivier Barthélemy

The prevalence of diabetes mellitus is increasing consistantly. Coronary artery disease (CAD) is the main cause of death; however, silent myocardial ischemia (SMI) is more frequent in diabetic patients. Early CAD diagnosis provided by SMI screening could lead to decreased cardiovascular complications and mortality. Current guidelines recommend screening for SMI in asymptomatic diabetic patients selected on a basis of high cardiovascular risk, followed by coronary angiogram in case of a positive stress test. However, the benefit of systematic SMI screening has not been demonstrated in diabetic patients with optimal treatment of risk factors. The benefit of revascularization in diabetic patients with SMI seems to be restricted to patients with severe CAD. Prospective studies are required to identify diabetic patients who may potentially benefit from SMI screening. These patients should have a high prevalence of severe CAD and potential benefit of revascularization, such as patients with renal failure, left ventricular dysfunction and peripheral or carotid occlusive arterial disease.

10.2217/fca.10.127

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Citations (15)

A randomized study comparing isotope and echocardiography stress testing in the screening of silent myocardial ischaemia in type 2 diabetic patients

Diabetes & Metabolism (2010)

Sophie Jacqueminet Olivier Barthélemy François Rouzet Richard Isnard Marine Halbron

Stress Echocardiography

10.1016/j.diabet.2010.06.005

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Citations (16)

Intensive cardiovascular risk factors therapy and prevalence of silent myocardial ischaemia in patients with type 2 diabetes

Archives of cardiovascular diseases (2008)

Olivier Barthélemy Sophie Jacqueminet François Rouzet Richard Isnard Anissa Bouzamondo

Microalbuminuria

10.1016/j.acvd.2008.06.015

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Citations (25)

Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality

JACC Heart Failure (2023)

Antonio Molinaro Ina Nemet Pierre Bel Lassen Rima Chakaroun Trine Nielsen

Over the past years, it has become clear that the microbial ecosystem in the gut has a profound capacity to interact with the host through the production of a wide range of bioactive metabolites. The microbially produced metabolite imidazole propionate (ImP) is clinically and mechanistically linked with insulin resistance and type 2 diabetes, but it is unclear how ImP is associated with heart failure. The authors aimed to explore whether ImP is associated with heart failure and mortality. ImP serum measurements in 2 large and independent clinical cohorts of patients (European [n = 1,985] and North American [n = 2,155]) with a range of severity of cardiovascular disease including heart failure. Univariate and multivariate Cox regression analyses were performed to delineate the impact of ImP on 5-year mortality in the North American cohort, independent of other covariates. ImP is independently associated with reduced ejection fraction and heart failure in both cohorts, even after adjusting for traditional risk factors. Elevated ImP was a significant independent predictor of 5-year mortality (for the highest quartile, adjusted HR: 1.85 [95% CI: 1.20-2.88]; P < 0.01). The gut microbial metabolite ImP is increased in individuals with heart failure and is a predictor of overall survival.

Quartile

Interquartile range

10.1016/j.jchf.2023.03.008

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Citations (25)

Iconographies supplémentaires de l'article : Sex-related differences after contemporary primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

Olivier Barthélemy Philippe Degrell Emmanuel Berman Mathieu Kernéis Thibaut Petroni

Elevation (ballistics)

Source

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Citations (0)

Multislice computed tomography to rule out coronary allograft vasculopathy in heart transplant patients