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Chantal Bridonneau

Microbiologie de l’alimentation au service de la santé

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Harry Sokol

Centre de Recherche Saint-Antoine

Sylvie Hudault

Université Paris-Saclay

Muriel Thomas

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Philippe Langella

Microbiologie de l’alimentation au service de la santé

Philippe Langella

Université Paris-Saclay

Bruno Lamas

Microbiologie de l’alimentation au service de la santé

Claire Cherbuy

Microbiologie de l’alimentation au service de la santé

Camille Mayeur

Microbiologie de l’alimentation au service de la santé

Marie‐Laure Michel

Microbiologie de l’alimentation au service de la santé

Grégory Da Costa

Unité de Recherche Œnologie

Cooperative Institutions

Inserm

Microbiologie de l’alimentation au service de la santé

Assistance Publique – Hôpitaux de Paris

Centre National de la Recherche Scientifique

AgroParisTech

Université Paris-Saclay

Sorbonne Université

Université Paris Cité

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Institut National de la Recherche Agronomique

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Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

Henri Duboc Sylvie Rajca Dominique Rainteau David Benarous Marie-Anne Maubert

Gut microbiota metabolises bile acids (BA). As dysbiosis has been reported in inflammatory bowel diseases (IBD), we aim to investigate the impact of IBD-associated dysbiosis on BA metabolism and its influence on the epithelial cell inflammation response.Faecal and serum BA rates, expressed as a proportion of total BA, were assessed by high-performance liquid chromatography tandem mass spectrometry in colonic IBD patients (42) and healthy subjects (29). The faecal microbiota composition was assessed by quantitative real-time PCR. Using BA profiles and microbiota composition, cluster formation between groups was generated by ranking models. The faecal BA profiles in germ-free and conventional mice were compared. Direct enzymatic activities of BA biotransformation were measured in faeces. The impact of BA on the inflammatory response was investigated in vitro using Caco-2 cells stimulated by IL-1β.IBD-associated dysbiosis was characterised by a decrease in the ratio between Faecalibacterium prausntizii and Escherichia coli. Faecal-conjugated BA rates were significantly higher in active IBD, whereas, secondary BA rates were significantly lower. Interestingly, active IBD patients exhibited higher levels of faecal 3-OH-sulphated BA. The deconjugation, transformation and desulphation activities of the microbiota were impaired in IBD patients. In vitro, secondary BA exerted anti-inflammatory effects, but sulphation of secondary BAs abolished their anti-inflammatory properties.Impaired microbiota enzymatic activity observed in IBD-associated dysbiosis leads to modifications in the luminal BA pool composition. Altered BA transformation in the gut lumen can erase the anti-inflammatory effects of some BA species on gut epithelial cells and could participate in the chronic inflammation loop of IBD.

Dysbiosis

Deoxycholic acid

10.1136/gutjnl-2012-302578

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Card9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Bruno Lamas Mathias Lavie-Richard Marie‐Laure Michel Valentin Leducq Chantal Bridonneau

Tryptophan Metabolism

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Microorganisms linked to inflammatory bowel disease-associated dysbiosis differentially impact host physiology in gnotobiotic mice

The ISME Journal (2015)

Thomas Hoffmann Hang‐Phuong Pham Chantal Bridonneau Camille Aubry Bruno Lamas

Bacteroides thetaiotaomicron

Dysbiosis

Roseburia

Saccharomyces boulardii

Ruminococcus

10.1038/ismej.2015.127

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Susceptibility of Card9-/- mice to intestinal pathogen is partly microbiota dependant.

HAL (Le Centre pour la Communication Scientifique Directe) (2016)

Bruno Lamas Nadine Waldschmitt Marie‐Laure Michel Jane M. Natividad Grégory Da Costa

Specific-pathogen-free

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Establishment of Bifidobacterium bifidum in the intestine of human neonates : relation with the bifidus factors found in the stools

HAL (Le Centre pour la Communication Scientifique Directe) (1990)

Sylvie Hudault Chantal Bridonneau P. Raibaud M.F. Vial

Bifidobacterium bifidum

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Early colonizing Esche richia coli elicits remodeling of rat colonic epithelium shifting toward a new homeostatic state

The ISME Journal (2014)

Julie Tomas Julie Reygner Camille Mayeur Robert Ducroc Stéphan Bouet

Goblet cell

Akkermansia muciniphila

10.1038/ismej.2014.111

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Effect of bovine or human milk on the establishment of Bifidobacterium bifidum and some other bacteria from the human neonatal microflora in gnotobiotic mice

Sylvie Hudault Chantal Bridonneau R. Ducluzeau P. Raibaud

Bifidobacterium bifidum

Bovine milk

Actinomycetaceae

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[Pathogenicity of various toxinogenic types of Clostridium perfringens administered by mouth to axenic and holoxenic mice].

Sylvie Hudault Chantal Bridonneau P Raibaud

Axenic mice died with signs of enterotoxaemia after oral ingestion of Clostridium perfringens type C or D. Under the same conditions, C. perfringens type B was less pathogenic, and types A and E showed no pathogenicity. The microflora of conventional mice prevented the establishment of C. perfringens types B, C and D in the digestive tract and protected them against the pathogenicity of these strains. Toxins produced in the caecum of monoxenic mice harbouring C. perfringens type C were not neutralized by the anti-C. perfringens type C antiserum. This suggests that the toxins produced in vivo by this strain were different from those produced in vitro.

Clostridium perfringens

Axenic

Caecum

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1057 Primo-Colonizing Bacteria Induce Maturation of Colonic Epithelium in Gnotobiotic Rat Models

Gastroenterology (2012)

Julie Tomas Camille Mayeur Chantal Bridonneau Marie-Louise Noordine Stéphan Bouet

10.1016/s0016-5085(12)60700-8

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Faecalibacterium prausnitzii Skews Human DC to Prime IL10-Producing T Cells Through TLR2/6/JNK Signaling and IL-10, IL-27, CD39, and IDO-1 Induction

Frontiers in Immunology (2019)

Joudy Alameddine Emmanuelle Godefroy Loukas Papargyris Guillaume Sarrabayrouse Julie Tabiasco

The human colonic mucosa contains regulatory type 1-like (Tr1-like, i.e. IL-10-secreting and Foxp3-negative) T cells specific for the gut Clostridium Faecalibacterium prausnitzii (F. prausnitzii), which are both decreased in Crohn's disease patients. These data, together with the demonstration, in mice, that colonic regulatory T cells (Treg) induced by Clostridium bacteria are key players in colon homeostasis, support a similar role for F. prausnitzii-specific Treg in the human colon. Here we assessed the mechanisms whereby F. prausnitzii induces human colonic Treg. We demonstrated that F. prausnitzii, but not related clostridia, skewed human dendritic cells to prime IL-10-secreting T cells. Accordingly, F. prausnitzii induced dendritic cells to express a unique array of potent Tr1/Treg polarizing molecules: IL-10, IL-27, CD39, IDO-1 and PDL-1 and, following TLR4 stimulation, inhibited their up-regulation of costimulation molecules as well as their production of pro-inflammatory cytokines IL-12 (p35 and p40) and TNFα. We further showed that these potent tolerogenic effects relied on F. prausnitzii-induced TLR2/6 triggering, JNK signaling and CD39 ectonucleotidase activity, which was induced by IDO-1 and IL-27. These data, together with the presence of F. prausnitzii-specific Tr1-like Treg in the human colon, point out to dendritic cells polarization by F. prausnitzii as the first described cellular mechanism whereby the microbiota composition may affect human colon homeostasis. Identification of F. prausnitzii-induced mediators involved in Tr1-like Treg induction by dendritic cells opens therapeutic avenues for the treatment of inflammatory bowel diseases.

Faecalibacterium prausnitzii

10.3389/fimmu.2019.00143

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Citations (87)

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