H-C Yang

ProQuest (United States)

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Yingting Zuo

Capital Medical University

L-J Ma

Central Hospital of Zibo

Pengfei Zhang

Johns Hopkins Medicine

Sebastian A. Potthoff

Heinrich Heine University Düsseldorf

Nazia Selzner

University Health Network

Oyedele Adeyi

University of Minnesota

Pei‐Jer Chen

National Taiwan University Hospital

Jia‐Horng Kao

National Taiwan University

Peter G. Gibson

John Hunter Hospital

Mezrich Fernandez

University of North Carolina at Chapel Hill

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National Institute of Diabetes and Digestive and Kidney Diseases

439

ProQuest (United States)

427

Bioengineering Center

274

The Japanese Society of Gastroenterological Surgery

Iwate Medical University

Hudson Institute

Jikei University School of Medicine

Showa University

Kyushu University

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Sustained hcv clearance and increased HBsAg seroclearance in patients with dual chronic hepatitis C and B during post-treatment follow-up.

余明隆李詮謀 Chun‐Liang Chen 莊萬龍盧勝男

Hepatitis C

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Citations (13)

Effect of Inhibition of the Central Nucleus of the Amygdala and Drug Experience on the Regions Underlying Footshock-Induced Reinstatement of Morphine Seeking

Journal of International Medical Research (2008)

DY Ma MY Xu H-C Yang LZ Yang

This study assessed the effect of inhibition of the central nucleus of the amygdala (CeA) and drug experience on brain regions underlying footshock-induced reinstatement of morphine-seeking behaviour in rats. The difference in time spent in two chambers of a place-preference apparatus was used to measure morphine-conditioned place preference. Fos was measured as a marker of neuronal activation in the ventral bed nucleus of the stria terminalis (BNSTv) and ventral tegmental area (VTA). Footshock was found to enhance Fos expression in the BNSTv regardless of drug experience. In the VTA, morphine and footshock had an interactive effect on the increase in Fos expression. Inhibition of the CeA decreased Fos expression in the BNSTv regardless of drug experience, whereas in the VTA this effect only occurred in morphine-treated rats. These results suggest that drug experience has no differential effect on the BNSTv however morphine produces footshock sensitization in the VTA. CeA inhibition modulates the footshock-induced activity of these regions of the brain and attenuates reinstatement of drug seeking behaviour.

Conditioned place preference

Extended amygdala

Differential effects

10.1177/147323000803600516

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Citations (14)

Liver & Pancreas

Laboratory Investigation (2008)

H-C Yang L-J Ma Yingting Zuo S. Potthoff Paul Tennant

10.1038/sj.labinvest.3700737

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Citations (0)

Liver & Pancreas

Laboratory Investigation (2009)

Pengfei Zhang W Li Yingting Zuo Sebastian A. Potthoff Tyler J. Brolin

10.1038/labinvest.2008.146

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Citations (0)

Liver & Pancreas

Modern Pathology (2009)

Pengfei Zhang W Li Yingting Zuo Sebastian A. Potthoff Tyler J. Brolin

10.1038/modpathol.2008.224

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Glucose 6-phosphate dehydrogenase deficiency enhances germ cell apoptosis and causes defective embryogenesis in Caenorhabditis elegans

Cell Death and Disease (2013)

H-C Yang T-L Chen Yi‐Hui Wu K-P Cheng Y-H Lin

Glucose 6-phosphate dehydrogenase (G6PD) deficiency, known as favism, is classically manifested by hemolytic anemia in human. More recently, it has been shown that mild G6PD deficiency moderately affects cardiac function, whereas severe G6PD deficiency leads to embryonic lethality in mice. How G6PD deficiency affects organisms has not been fully elucidated due to the lack of a suitable animal model. In this study, G6PD-deficient Caenorhabditis elegans was established by RNA interference (RNAi) knockdown to delineate the role of G6PD in animal physiology. Upon G6PD RNAi knockdown, G6PD activity was significantly hampered in C. elegans in parallel with increased oxidative stress and DNA oxidative damage. Phenotypically, G6PD-knockdown enhanced germ cell apoptosis (2-fold increase), reduced egg production (65% of mock), and hatching (10% of mock). To determine whether oxidative stress is associated with G6PD knockdown-induced reproduction defects, C. elegans was challenged with a short-term hydrogen peroxide (H2O2). The early phase egg production of both mock and G6PD-knockdown C. elegans were significantly affected by H2O2. However, H2O2-induced germ cell apoptosis was more dramatic in mock than that in G6PD-deficient C. elegans. To investigate the signaling pathways involved in defective oogenesis and embryogenesis caused by G6PD knockdown, mutants of p53 and mitogen-activated protein kinase (MAPK) pathways were examined. Despite the upregulation of CEP-1 (p53), cep-1 mutation did not affect egg production and hatching in G6PD-deficient C. elegans. Neither pmk-1 nor mek-1 mutation significantly affected egg production, whereas sek-1 mutation further decreased egg production in G6PD-deficient C. elegans. Intriguingly, loss of function of sek-1 or mek-1 dramatically rescued defective hatching (8.3- and 9.6-fold increase, respectively) induced by G6PD knockdown. Taken together, these findings show that G6PD knockdown reduces egg production and hatching in C. elegans, which are possibly associated with enhanced oxidative stress and altered MAPK pathways, respectively.

10.1038/cddis.2013.132

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Citations (47)

Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK–JMJD3–p16INK4a signaling axis

Oncogene (2011)

Tzu‐Yang Lin Y-C Cheng H-C Yang Wen‐chang Lin C-C Wang

Senescence

Retinoblastoma protein

10.1038/onc.2011.491

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Citations (49)

Issue Information

Journal of Gastroenterology and Hepatology (2019)

Joseph J.�Y. Sung Hong Kong Akira Andoh Shiga Tiing Leong Ang

No abstract is available for this article.

10.1111/jgh.14323

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The self-reported experiences of siblings who have a brother or sister diagnosed with childhood cancer: a systematic review of qualitative evidence

International Journal of Evidence-Based Healthcare (2013)

H-C Yang P-F Mu C-C Sheng Yu‐Wei Chen

1Taiwan Joanna Briggs Institute Collaborating Center, Taiwan, 2School of Nursing, National Yang-Ming University, Taipei, Taiwan, 3School of Nursing, Hungkuang University, Taichung, Taiwan, 4Department of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan, 5Cancer Center, Taipei Veterans General Hospital, Taipei, Taiwan, 6School of Medicine, National Yang-Ming University, Taipei, Taiwan

Sister

Center (category theory)

Childhood Cancer

10.1097/01258363-201309000-00096

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Liver & Pancreas

Laboratory Investigation (2010)

Hong Xiao Yong Zeng Pardo-Manuel De Villena Dominic J. Ciavatta Ronald J. Falk

10.1038/labinvest.2010.25

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