Wenfeng Bao

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Jun Fang

Inner Mongolia International Mongolian Hospital

Sarnai Arlud

Inner Mongolia International Mongolian Hospital

Haorile Chagan‐Yasutan

Tohoku University

Rihan Wu

Sun Yat-sen University

Si Qin

Inner Mongolia International Mongolian Hospital

Nagongbilige He

Inner Mongolia International Mongolian Hospital

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Inner Mongolia International Mongolian Hospital

Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences

Inner Mongolia Agricultural University

Xiamen University

Wuhan University

Jiangsu University

First People's Hospital of Kunshan

Wuhan University of Technology

Hunan University of Science and Technology

Xianning Central Hospital

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Mechanism of Mongolian Mind-Body Interactive Therapy in Regulating Essential Hypertension Through HTR2B: A Metabolome- and Transcriptome-Based Study

Heliyon (2024)

Jun Fang Wenfeng Bao Haorile Chagan‐Yasutan Sarnai Arlud Si Qin

Essential hypertension is a psychosomatic disease associated with emotions and behaviors. Although Mongolian mind-body interactive therapy can help patients with essential hypertension reduce their systolic blood pressure (SBP), the mechanism is unclear. We assigned patients who underwent Mongolian mind-body interactive therapy to groups that were treated with (DT) or without (NDT) antihypertensive drugs (Clinical registration no: ChiCTR2000034918). We screened differentially expressed genes (DEGs) using targeted metabolic and transcriptomic analyses of blood samples before and after intervention. Sequenced data were analyzed using quantitative polymerase chain reaction (qPCR) and validated using enzyme-linked immunosorbent assays (ELISAs). Small interfering (Si)-RNA interference on key DEGs in human umbilical vein endothelial cells (HUVECs) was experimentally verified. Omics analysis identified 187 DEGS, including human 5-hydroxytryptamine (5-HT) receptor 2B (5-

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Essential hypertension

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10.1016/j.heliyon.2024.e37113

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