L. K. Yu

Union Hospital

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Li Shen

Central South University

Yuanlin Song

Zhongshan Hospital

Yangyang Du

China General Nuclear Power Corporation (China)

F. Wang

Huazhong University of Science and Technology

Lifeng Tian

Jiangxi Maternal and Child Health Hospital

J. F. Zhu

Wuhan Union Hospital

Ran Du

Huazhong University of Science and Technology

Cooperative Institutions

First Affiliated Hospital of Zhengzhou University

Central South University

Sichuan University

Huazhong University of Science and Technology

Second Xiangya Hospital of Central South University

Tianjin Medical University

Tianjin Anding Hospital

Air Force Medical University

Eastern Hepatobiliary Surgery Hospital

Second Military Medical University

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Association of the CD226 single nucleotide polymorphism with systemic lupus erythematosus in the Chinese Han population

Tissue Antigens (2010)

Yangyang Du Lifeng Tian Li Shen F. Wang L. K. Yu

A novel non‐synonymous (Gly307Ser) variant, rs763361, of the CD226 gene on chromosome 18q22 was recently shown to be associated with multiple autoimmune diseases. Taking into consideration that different autoimmune diseases may share some common pathogenic pathways, in this study we performed case–control studies to assess any genetic linkage with systemic lupus erythemtosus (SLE). An association between the Gly307Ser single nucleotide polymorphism (SNP) and susceptibility to SLE was identified. The TT genotype [odds ratio (OR) = 1.79, 95% confidence interval (CI) = 1.07–3.01, P = 0.025] and the T allele (OR = 1.34, 95% CI = 1.05–1.74, P = 0.018) of the rs763361 SNP were associated with the risk of SLE. This finding indicates that polymorphism of Gly307Ser (rs763361) in exon 7 of the CD226 gene may be associated with the development of SLE.

SNP

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10.1111/j.1399-0039.2010.01568.x

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Citations (25)