Xiao‐Dong Deng

North Sichuan Medical University

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i-10 index

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Ying Ma

Nanjing Drum Tower Hospital

Yun Liu

Sichuan University

Huan Liu

North Sichuan Medical University

Zhenhua Deng

Chongqing Medical University

Qin Gao

Taizhou University

Lixia Zhang

Institute of Atmospheric Physics

Hong Li

Shanghai Children's Medical Center

Y. Zhang

Southern Medical University

Bin Cong

Hebei Medical University

Yun Liu

Fudan University

Cooperative Institutions

Sichuan University

North Sichuan Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

West China Medical Center of Sichuan University

Chinese Academy of Sciences

Affiliated Hospital of North Sichuan Medical College

Peking University

Fudan University

Capital Medical University

Jilin University

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ERCC1 polymorphism and its expression associated with ischemic stroke in Chinese population

Frontiers in Neurology (2023)

Xiao‐Dong Deng Ke Jianlin Taiyu Chen Qin Gao Zhuolin Zhao

Background Excision repair cross-complementing group 1 ( ERCC1 ) was considered a potential candidate gene for ischemic stroke, and its polymorphisms might be associated with the susceptibility to ischemic stroke. Methods A total of 513 patients with ischemic stroke and 550 control subjects were recruited. The expression levels of ERCC1 messenger RNA (mRNA) in peripheral blood mononuclear cells and its protein in plasma were detected by quantitative real-time PCR ( qPCR ) and enzyme-linked immunosorbent assay ( ELISA ), respectively. Rs3212986 polymorphism of ERCC1 was detected by PCR-restriction fragment length polymorphism ( RFLP-PCR ) and was confirmed by sequencing. The association between the ERCC1 rs3212986 polymorphism or its expression and ischemic stroke was further analyzed. Results The ERCC1 mRNA level in patients with ischemic stroke was lower than that in the control group ( P < 0.05). However, the ERCC1 protein level in patients with ischemic stroke was higher than that in the control group ( P < 0.05). The A allele of rs3212986 was associated with increased ischemic stroke risk (OR = 1.287, 95% CI = 1.076–1.540, P = 0.006). The association between rs3212986 polymorphism and ischemic stroke susceptibility was found in both recessive (OR = 2.638, 95% CI = 1.744–3.989, P < 0.001) and additive models (OR = 1.309, 95% CI = 1.028–1.667, P = 0.031), respectively. Similar results were obtained in the recessive model (OR = 2.015, 95% CI = 1.087–3.704, P = 0.026) after adjusting for demographic information and other variables. Additionally, the level of ERCC1 mRNA in the CC/CA genotype was higher than that in the AA genotype ( P < 0.05). Conclusion It was suggested that the ERCC1 rs3212986 polymorphism was associated with ischemic stroke susceptibility in a Chinese Han population and that an A allele of rs3212986 was related to increased ischemic stroke risk. The altered ERCC1 expression level caused by the rs3212986 polymorphism might participate in the pathophysiological process of ischemic stroke.

ERCC1

Stroke

10.3389/fneur.2022.998428

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Acupuncture for emotional disorders in patients with inflammatory bowel disease: a systematic review protocol

BMJ Open (2022)

Yuanfang Zhou Guilong Zhang Ning Sun Zhongquan Wang Xiangyin Ye

Introduction Emotional disorders are often observed in inflammatory bowel disease (IBD). IBD with emotional disorders leads to poor quality of life. This systematic review aims to assess the effectiveness of acupuncture in patients with IBD with emotional disorders. Methods and analysis Nine electronic databases, including Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Allied and Complementary Medicine Database, Cumulative Index to Nursing & Allied Health Literature, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Database and Wanfang Database, will be searched from inception to October 2021 without language restriction. The grey literature containing conference proceedings, as well as systematic reviews listed in the reference of definite publications, will also be retrieved. Randomised controlled trials either in English or Chinese reporting acupuncture therapy for IBD with emotional disorders will be included. The primary outcome is changes of emotional functioning outcomes. The Colitis Activity Index, Crohn’s Disease Activity Index, C reactive protein and adverse events will be assessed as the secondary outcomes. More than two assessors will conduct the study retrieval and selection, as well as the data extraction and evaluation of the risk of bias. Data synthesis will be performed using a random-effects model based on the results of heterogeneity. Data analysis will be performed using RevMan software (V.5.4). Moreover, the dichotomous data will be presented as risk ratios, and the continuous data will be calculated using weighted mean difference or standard mean difference. Ethics and dissemination This systematic review contains no individual patient data; thus, ethical approval is not required. Moreover, this review will be disseminated in a peer-reviewed journal or relevant conference. PROSPERO registration number CRD42020176340.

Data extraction

10.1136/bmjopen-2021-058568

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Microscopic observations of CrPUB gene RNAi transgenic algae.

Luo Qiulan Yajun Li Wen‐Quan Wang Xiaowen Fei Xiao‐Dong Deng

10.1371/journal.pone.0122600.g010

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Comparative study of the synchronized estrus on four breed goat with embryo transfer recipients

Xi'nan nongye xuebao (2005)

Jian Li Ma Baohua Zhang Hong Xiao‐Dong Deng Zhou HongQun

The synchronized estrus were induced by three kinds of methods for 713 Ya'an Milk Goats, 728 Chengdu Ma Goat, 366 Jianyang Big-ear goat and 334 Nanjiang Yellow Goat. The results showed that the percentages of synchronized estrus in four breed goats were 92.3 %(658/713), 92.7 %(675/728), 91.7%(336/366)and 90.4 %(302/334), respectively, the percentages of estrus recipients with corpus luteum on their ovary were 71.0 %(467/658),67.1 %(453/675),69.9%(235/336)and 63.9 %(193/302), respectively, the time separations from removed norestrel-impregnated intravaginal sponges to onset of estrus were 43.3±14.3, 47.0±20.5, 42.8±13.0, 50.8±19.4 h, respectively, the duration of estrus were 44.8±14.9, 43.8±19.3, 39.8±13.4, 40.8±19.1 h, respectively.

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FAM-Former: Global Transformer and Feature Aggregation Module for Knee MRI Age Estimation

IEEE Transactions on Instrumentation and Measurement (2023)

Linchao He H. H. Zhu Xiao‐Dong Deng Fei Fan Peixi Liao

Age estimation is a significant and active research field in radiological medicine. Recently, researchers have turned their attention to magnetic resonance imaging (MRI) for age estimation, primarily due to concerns regarding ionizing radiation in traditional imaging techniques. In this paper, based on the knee MRI dataset, we present a novel end-to-end network that combines convolutional neural network (CNN) and visual transformer network to extract complementary features. Additionally, we introduce a feature aggregation module (FAM) that aggregates features from different local knee MRI slices. Our proposed method integrates the feature maps from CNN with the patch embeddings of visual transformer branches, allowing for the acquisition of both local and global information necessary for extracting age-related features. Moreover, we introduce a feature aggregation module utilizing the graph attention network (GAT) to achieve interaction between multiple slice features at the feature level. Through extensive experiments conducted on a dataset of 80 knee MRI samples spanning ages 12.0 to 25.9 years, our method has demonstrated state-of-the-art performance in knee MRI age estimation. Specifically, in a five-fold cross-validation setup, we achieved a mean absolute error of 1.52 ± 1.27 years in age regression.

Feature (linguistics)

10.1109/tim.2023.3345906

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Volume flow measurements with a novel semi-automated 4D doppler ultrasound scanner

Flemming Forsberg J.B. Liu Alan Stein Xiao‐Dong Deng William E. Ackerman

The Encore PV is a novel, real time 3D (i.e., 4D) ultrasound scanner capable of measuring blood flow. In vitro and in vivo volume flow measurements obtained from the Encore were compared to those from an invasive transit time flowmeter. A flow pump was used to simulate carotid type waveforms with pulsatile flow rates from 60 to 600 ml/min. Encore volume flows were compared to an invasive technique for volumetric blood flow measurement utilizing a transit time flowmeter. In vivo 10 s data sets of the volume flow in the distal aorta of 6 rabbits were obtained simultaneously with the Encore PV and the flowmeter. Mean and maximum volume flows were recorded with both units. Data was compared using linear regression and Bland-Altman analysis. It was found that volume flow measurements with this unit are comparable to those of an invasive flowmeter.

Pulsatile flow

Ultrasonic flow meter

Doppler ultrasound

10.1109/ultsym.2004.1418251

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In vitro Transient Expression System of Latex C‐serum was used for Analysis of Hevein Promoter in Response to Abscisic Acid in Hevea brasiliensis

Journal of Integrative Plant Biology (2008)

Xiaowen Fei Xiao‐Dong Deng

Hevein has been found to be an essential element in coagulation of rubber particles in latex of rubber trees. In a previous study, we cloned a 1,241-bp fragment of a 5' upstream region of the hevein gene by genome walking. This fragment was analyzed by a 5' end nested deletion method in the present study, fused with a uidA (gus) gene to produce a series of tested constructs, which were transferred into C-serum of latex and the Gus activities were detected. Results showed that the fragment from -749 to -292 was sufficient for expression of gus gene in latex, and the fragment from -292 to -168 was crucial in response to abscisic acid inducement. In a transient transgenic test of rubber leaf with particle bombardment, construct Hev749 conferred gus-specific expression in veins, in which the latex tubes mainly distributed. This implies that the fragment from -749 to -292 was laticiferous-specific.

Hevea

10.1111/j.1744-7909.2007.00628.x

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Association of XPF Levels and Genetic Polymorphism with Susceptibility to Ischemic Stroke

Journal of Molecular Neuroscience (2016)

Ying Ma Xiao‐Dong Deng Feng Yu Wei Zhang Sun-Xian Wang

Pathophysiology

Stroke

10.1007/s12031-016-0729-4

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Comparative study of the embryo transfer efficiency on four breed recipients with embryo transfer in boer goat

Ma Baohua Hong Zhang Jian Li Xiao‐Dong Deng Hong Li

Boer goat embryos were transferred surgically, when 1,2,3 or 4 embryo were transferred, the pregnancy rates of recipients were 60.2 %(171/284),62.7 %(540/862),64.0 %(16/25) and 54.6 %(6/11), separately, and the rates of embryos developing into kids were 60.2 %(171/284),51.6 %(890/1724),41.3 %(31/75) and 36.4 %(16/44), separately. The pregnancy rates and embryo developing rates were not significantly different among Ya'an Milk Goat, Chengdu Ma Goat, Jianyang Big-ear Goat and Nanjiang Yellow Goat when single embryo per recipient were transferred (P0.05). When double embryos per recipient were transferred, the pregnancy rate and embryo developing rate of Milk Goat were significantly higher than that of Ma Goat or Big-ear Goat(P0.05),and the rates of Nanjiang Yellow Goat were higher than that of Ma Goat or Big-ear Goat, and lower than that of Milk Goat, but there were not significantly different (P0.05). The number of corpus luteum had no significant effect on pregnancy rates and embryo developing rates.

Boer goat

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Association of IL-8-251A/T polymorphism with acute pancreatitis susceptibility: A meta-analysis

Shijie huaren xiaohua zazhi (2018)

Huan Liu Wei Zhang Xiao‐Dong Deng Ying Ma Yun Liu

10.11569/wcjd.v26.i3.174

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