Abbas Hadjiakhoondi

Tehran University of Medical Sciences

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Mahnaz Khanavi

Tehran University of Medical Sciences

Zahra Tofighi

Tehran University of Medical Sciences

Hassan Vatandoost

Tehran University of Medical Sciences

Saied Goodarzi

Tehran University of Medical Sciences

Narguess Yassa

Tehran University of Medical Sciences

Saeed Tavakoli

Academic Center for Education, Culture and Research

Soodabeh Saeidnia

Tehran University of Medical Sciences

Samad Nejad Ebrahimi

Shahrekord University of Medical Sciences

Azadeh Manayi

Tehran University of Medical Sciences

Fahimeh Moradi-Afrapoli

University of Basel

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Tehran University of Medical Sciences

117

University of Tehran

Academic Center for Education, Culture and Research

Biotechnology Research Center

Iranian Research Institute of Plant Protection

Shahid Beheshti University of Medical Sciences

Institute of Medicinal Plant Development

Tabriz University of Medical Sciences

Mazandaran University of Medical Sciences

Ministry of Health and Medical Education

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Elucidation of Apigenin Derivatives from Ethyl Acetate Fraction of Stachys byzantina with Potent Antioxidant and Anti-Staphylococcus aureus Properties

Traditional and Integrative Medicine (2023)

M Pirali Hamedani Farzaneh Aram Abbas Hadjiakhoondi Nasrin Samadi Saeed Tavakoli

The Stachys genus is a medicinal plant, with 34 different species, from Lamiaceae family that grows in Irano-Anatolian plateau. There are 12 species of Stachys native to Iran. Some species of Stachys have been used in traditional medicine of Iran, Turkey, Italy, Greece, China, and Japan for the treatment of various diseases like inflammation and common cold. Some researchers have noted many biological effects, such as cytotoxic, antioxidant, immunomodulator, anti-inflammatory and antibacterial effects for the members of this genus. There are a few evidences on phytochemical constituents of S. byzanthina. The aim of this study was phytochemical investigation of various extracts of this plant to obtain the most efficient fractions and compound(s) to study the antimicrobial effects of this plant. Separation and isolation of compounds was performed by various methods of chromatography. The structure of each compound was identified by spectroscopic methods. Antimicrobial studies were performed on different fractions of S. byzantina by microdilution method and to determine the Minimum Inhibitory Concentration (MIC), agar well diffusion was done. Ethyl acetate fraction has the highest total phenol contents (1082.05 mg GAE/g fraction) and antioxidant capacity (IC50= 1.23 mg/mL). Also, ethyl acetate fraction, the most potential fraction of S. byzanthina, demonstrated the largest inhibition zone (17.5 ± 0.7 mm) with 5 mg/mL in MIC against Staphylococcus auresus. Apigenin and its derivatives were isolated from this fraction and according to literature; they can be responsible for antibacterial activity of this fraction of S. byzanthina.

Phytochemical

Agar diffusion test

10.18502/tim.v8i2.13082

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Composition of the volatile oils of Satureja spicigera C. Koch Boiss. and S. macrantha C. A. Mey from Iran

Flavour and Fragrance Journal (2006)

Ahmad Reza Gohari Abbas Hadjiakhoondi Esmaeil Sadat‐Ebrahimi Soodabeh Saeidnia Abbas Shafiee

Abstract The essential oils of the aerial parts of Satureja spicigera (C. Koch) Boiss. and S. macrantha C. A. Mey., from Iran, have been analysed by GC and GC–MS. Forty‐three compounds in the oil of S. spicigera , representing 97.4% of the total oil, and 48 compounds in the oil of S. macrantha , representing 92.1%, were identified. The oil of S. spicigera was rich in monoterpenes (89.9%) with thymol (37.3%) as the major compound, but the oil of S. macrantha consists of approximately equal amounts of monoterpenes and sesquiterpenes (34.2% and 30.8%, respectively) with spathulenol (14.0%) as the main component. Copyright © 2006 John Wiley & Sons, Ltd.

Satureja

Thymol

10.1002/ffj.1613

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Citations (15)

Isoimperatorin alleviates acetic acid–induced colitis in rats

Asian Pacific Journal of Tropical Biomedicine (2024)

Saied Goodarzi Amir Hossein Abdolghaffari Behnaz Najafi M Pirali Hamedani Saeed Tavakoli

Objective: To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis rats. Methods: Colitis was induced by intracolonic administration of acetic acid solution (4% v/v ) in rats. Rats were divided into six groups including the sham group, the negative control group, the dexamethasone-treated group, and the groups treated with isoimperatorin (0.1, 1, and 10 mg/kg/d by gavage). The treatments were administered for three days and then colonic status was assessed by macroscopic, histopathological, and biochemical analyses. Results: Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced colitis. It also significantly reduced myeloperoxidase, TNF-α, IL-1β, and malodialdehyde levels. Conclusions: Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.

Rat model

10.4103/apjtb.apjtb_851_23

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Citations (1)

Antiprotozoal activity of diterpenoids isolated from Zhumeria majdae- absolute configuration by circular dichroism

DARU Journal of Pharmaceutical Sciences (2020)

Reza Zadali Samad Nejad Ebrahimi Zahra Tofighi Ali Es‐haghi Matthias Hamburger

Antiprotozoal

Absolute Configuration

Trypanosoma brucei rhodesiense

Phytochemical

10.1007/s40199-020-00345-w

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Citations (11)

Remarkable Variation in Phytochemicals of Ferula gummosa Bioss. Essential Oils Collected From Different Parts of Iran

DOAJ (DOAJ: Directory of Open Access Journals) (2022)

Saied Goodarzi Mansour Mofasseri Zahra Tofighi M Pirali Hamedani Abbas Hadjiakhoondi

Variation (astronomy)

10.22127/rjp.2022.345563.1917

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Larvicidal Activity of Centaurea bruguierana ssp. belangerana Against Anopheles stephensi Larvae.

PubMed (2011)

Mahnaz Khanavi Afsaneh Rajabi Masoud Behzad Abbas Hadjiakhoondi Hassan Vatandoost

In this study, the total 80% of MeOH extract and also petroleum ether, CHCl3, EtOAc, n-BuOH, and the remaining MeOH fractions obtained by solvent-solvent fractionation of the whole flowering samples of Centaurea bruguierana (DC.) Hand.-Mzt. ssp. belangerana (DC.) Bornm. (Asteraceae), namely "Baad-Avard", collected from Borazjan in Bushehr Province (Bushehr, Iran) were investigated for larvicidal activity against malaria vector, Anopheles stephensi Liston, according to WHO methods. The mortality rate of total extract and petroleum ether fraction in concentration of 40 ppm were 28% and 86% respectively and the other fractions were inactive. The probit regression analysis for the dose-response to petroleum ether fraction treatment of larvae exhibited the LC50 and LC90 values of 15.7 ppm and 48.3 ppm, respectively. As results showed, the larvicidal activity of the petroleum ether fraction would be due to the nonpolar compounds in the plant which further isolation and purification would obtain the more active compounds in lower concentrations useful for preparation of biological insecticides.

Anopheles stephensi

Petroleum ether

Fraction (chemistry)

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Citations (10)

Cytotoxic evaluation of Melia azedarach in comparison with, Azadirachta indica and its phytochemical investigation

DARU Journal of Pharmaceutical Sciences (2013)

Samineh Jafari Soodabeh Saeidnia Homa Hajimehdipoor Mohammad Reza Shams Ardekani Mohammad Ali Faramarzi

Melia azedarach

Azadirachta

Meliaceae

Phytochemical

MTT assay

IC50

10.1186/2008-2231-21-37

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Citations (41)

Larvicidal activity of marine algae, Sargassum swartzii and Chondria dasyphylla, against malaria vector Anopheles stephensi.

PubMed (2011)

Mahnaz Khanavi Pouyan Bagheri Toulabi Mohammad Reza Abai Nargess Sadati Farzaneh Hadjiakhoondi

The objective of this study was to evaluate larvicidal activity of native marine algae against main malaria vector Anopheles stephensi.

Anopheles stephensi

Sargassum

Source

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Citations (30)

Armenin and Isoarmenin – Two Prenylated Coumarins from the Aerial Parts of Artemisia armeniaca

Chemistry & Biodiversity (2011)

Mahdi Mojarrab Abbas Delazar Sadeighe Bamdad Moghadam Hossein Nazemiyeh Lutfun Nahar

The reversed-phase (RP) preparative HPLC analyses of the MeOH extract of the aerial parts of Artemisia armeniaca yielded four prenylated coumarins, 7-hydroxy-8-(4-hydroxy-3-methylbutoxy)coumarin (named armenin), 8-hydroxy-7-(4-hydroxy-3-methylbutoxy)coumarin (named isoarmenin), lacarol, and deoxylacarol, together with five other compounds, including three flavonoid glycosides, quercetin 3-O-β-D-glucopyranoside, rutin, and kaempferol 3-O-β-D-glucopyranoside, and chlorogenic acid, and tryptophan. (10E,12Z)-9-Hydroxyoctadeca-10,12-dienoic acid (β-dimorphecolic acid) was isolated from the CH(2)Cl(2) extract. Armenin and isoarmenin were new coumarins. Structures of all compounds were determined by spectroscopic means, including UV, MS, 1D- and 2D-NMR. The in vitro free-radical-scavenging property of the extracts and isolated compounds was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.

Chlorogenic Acid

Chromone

10.1002/cbdv.201000284

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Citations (21)

Azerosides A and B: Two new phloroacetophenone glycosides from the roots of Dorema glabrum Fisch. & C.A. Mey

Medicinal Chemistry Research (2014)

Mohammad‐Reza Delnavazi Abbas Hadjiakhoondi Abbas Delazar Yousef Ajani Narguess Yassa

Chlorogenic Acid

Phytochemical

Sephadex

Stigmasterol

10.1007/s00044-014-1138-2

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Citations (14)