Stephen A. Cooper

Cooper and Company (United States)

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Paul J. Desjardins

Rutgers, The State University of New Jersey

Elliot V. Hersh

University of Pennsylvania

D. C. Reynolds

Wright State University

Raymond A. Dionne

American Dental Association

Geraldine Doyle

Prince Charles Hospital

Gustav O. Kruger

Georgetown University

Alberto Paredes-Diaz

Bayer (United States)

Robert Centofanti

Bayer (United States)

John T. Farrar

University of Pennsylvania

Emanuel Troullos

Bayer (United States)

Cooperative Institutions

Therapeutics Clinical Research

Ibero American University

University of Pennsylvania

Pfizer (United States)

University of Washington

Rutgers, The State University of New Jersey

Harvard University

Johnson & Johnson (United States)

Georgetown University

Smiths Detection (Canada)

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Conventional and extended-release etodolac for postsurgical dental pain

Clinical Therapeutics (1999)

Elliot V. Hersh Lawrence M. Levin Stephen A. Cooper D. C. Reynolds L. Thomas Gallegos

This double-masked, parallel-group, randomized study compared the analgesic efficacy and tolerability of a single investigational 1200-mg dose of extended-release etodolac with those of a single 400-mg dose of extended-release etodolac and twice-daily doses of conventional etodolac 200 and 400 mg and placebo given 8 hours apart in 237 patients with moderate or severe postoperative pain following surgical removal of ≥2 impacted third molars. Both doses of conventional etodolac and the 1200-mg dose of extended-release etodolac were significantly more effective on all summary analgesic measures than placebo (P < 0.05). Conventional etodolac had an onset of analgesic activity within 45 (400 mg) to 60 (200 mg) minutes and an analgesic duration of 5 to 6 hours. Extendedrelease etodolac 1200 mg had an onset of action within 60 minutes and an analgesic duration of 12 to 24 hours. At hours 2 and 3, conventional etodolac 400 mg was significantly more effective than the other treatments; from hours 6 through 12, extended-release etodolac 1200 mg was significantly more effective than the other treatments (both, P < 0.05). No serious adverse events were observed in this study, with an incidence of side effects in the active etodolac groups no different than that with placebo. Extended-release etodolac 1200 mg has a prolonged analgesic duration and an acceptable side-effect profile in the oral surgery pain model.

Etodolac

Tolerability

10.1016/s0149-2918(99)80034-4

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Citations (15)

The Russell R. Miller Memorial Analgesic Issue

Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy (1986)

Paul J. Desjardins Stephen A. Cooper

Miller

10.1002/j.1875-9114.1986.tb03476.x

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Citations (0)

Chronic tryptophan depletion disrupts novel object recognition memory in the rat.

JE Elliott Tara Ardis Marie Cahir Trisha A. Jenkins Gavin P. Reynolds

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Suppression of Postoperative Pain by Preoperative Administration of Ibuprofen in Comparison to Placebo, Acetaminophen, and Acetaminophen Plus Codeine

The Journal of Clinical Pharmacology (1983)

Raymond A. Dionne Robert A. Campbell Stephen A. Cooper David Hall Barbara Buckingham

Abstract: The analgesic effect of preoperatively administered ibuprofen was evaluated in 107 dental outpatients undergoing the removal of impacted third molars. Subjects were given 800 mg ibuprofen prior to the procedure and 400 mg ibuprofen 4 and 8 hours later. Comparison was made to groups receiving either placebo at all three doses, 600 mg acetaminophen administered on the same schedule, or preoperatively administered placebo followed by two doses of postoperatively administered 600 mg acetaminophen plus 60 mg codeine. Ibuprofen pretreatment resulted in significantly less pain than placebo or acetaminophen pretreatment as the local anesthetic wore off. Ibuprofen also resulted in less postoperative pain than acetaminophen plus codeine following the second dose. Side effects were similar across drug teatments and placebo with the exception of greater reports of drowsiness following the opiate—analgesic combination. These findings indicate that pretreatment with a nonsteroidal antiinflammatory drug, such as ibuprofen, results in a suppression of postoperative pain when compared to standard therapy without an increase in side effects.

Ibuprofen

Acetaminophen

10.1002/j.1552-4604.1983.tb02702.x

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Citations (207)

Double-blind, randomized, parallel, placebo-controlled study of ibuprofen effects on thromboxane B2 concentrations in aspirin-tereated healthy adult volunteers

Clinical Therapeutics (2005)

Byron Cryer Roger G. Berlin Stephen A. Cooper Ching Hsu Suman Wason

Ibuprofen

10.1016/j.clinthera.2005.01.011

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Citations (43)