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MS

Motoshi Suzuki

National Institutes of Health

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Nico Tjandra

National Heart Lung and Blood Institute

Richard J. Youle

National Institutes of Health

L. Renee Olano

National Institute of Allergy and Infectious Diseases

Masaki Terabe

National Institutes of Health

Lise Pasquet

National Cancer Institute

Glenn Nardone

National Institutes of Health

Jay A. Berzofsky

National Institutes of Health

Kenneth L. Pitter

Memorial Sloan Kettering Cancer Center

David L. Narum

National Institute of Allergy and Infectious Diseases

José M. C. Ribeiro

Vector Oncology (United States)

Cooperative Institutions

National Institutes of Health

National Institute of Allergy and Infectious Diseases

National Cancer Institute

Center for Cancer Research

Harvard University

Fujita Health University

National Institute of Neurological Disorders and Stroke

National Heart Lung and Blood Institute

Johns Hopkins University

University of Maryland, Baltimore

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Structural Analysis of a BAX-BIM SAHB Complex Reveals a Novel BH3 Interaction Site on BAX for Therapeutic Activation of Apoptosis

Evripidis Gavathiotis Motoshi Suzuki Marguerite L. Davis Kenneth L. Pitter Gregory H. Bird

Bcl-2-associated X protein

Bcl-2 Family

10.1182/blood.v112.11.300.300

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Citations (1)

Structure of Bax

Motoshi Suzuki Richard J. Youle Nico Tjandra

10.1016/s0092-8674(00)00167-7

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Citations (1,068)

Short stature and combined immunodeficiency associated with mutations in RGS10

Science Signaling (2021)

Iván K. Chinn Zhihui Xie Eunice C. Chan Bianca M. Nagata Alexey Koval

Rare variants in RGS10 are linked to growth impairment and inborn errors of immunity.

10.1126/scisignal.abc1940

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Citations (4)

Si基板上へのMg 2 Si 1-x Ge x 系ナノロッドの作製

応用物理学関係連合講演会講演予稿集(CD-ROM) (2010)

Yang Qing Furuki Hiroki Hara Hideki Motoshi Suzuki Tatsuoka Hirokazu

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Host cell protein quantification of an optimized purification method by mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis (2019)

Karine Reiter Motoshi Suzuki L. Renee Olano David L. Narum

Protein precipitation

Protein purification

Sample Preparation

10.1016/j.jpba.2019.06.038

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Citations (9)

Simple multidimensional NMR experiments to obtain different types of one-bond dipolar couplings simultaneously.

Journal of Biomolecular NMR (2001)

Eva de Alba Motoshi Suzuki Nico Tjandra

Residual dipolar coupling

Pulse sequence

Magnetic dipole–dipole interaction

10.1023/a:1008341128327

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Citations (19)

BAX activation is initiated at a novel interaction site

Evripidis Gavathiotis Motoshi Suzuki Marguerite L. Davis Kenneth L. Pitter Gregory H. Bird

Bcl-2-associated X protein

Bcl-2 Family

10.1038/nature07396

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Citations (657)

Comprehensive Proteomics Analysis of the Hemolymph Composition of Sugar-Fed Aedes aegypti Female and Male Mosquitoes

Journal of Proteome Research (2024)

Patrícia H. Alvarenga Thiago Luiz Alves e Silva Motoshi Suzuki Glenn Nardone Pedro Cecílio

In arthropods, hemolymph carries immune cells and solubilizes and transports nutrients, hormones, and other molecules that are involved in diverse physiological processes including immunity, metabolism, and reproduction. However, despite such physiological importance, little is known about its composition. We applied mass spectrometry-based label-free quantification approaches to study the proteome of hemolymph perfused from sugar-fed female and male Aedes aegypti mosquitoes. A total of 1403 proteins were identified, out of which 447 of them were predicted to be extracellular. In both sexes, almost half of these extracellular proteins were predicted to be involved in defense/immune response, and their relative abundances (based on their intensity-based absolute quantification, iBAQ) were 37.9 and 33.2%, respectively. Interestingly, among them, 102 serine proteases/serine protease-homologues were identified, with almost half of them containing CLIP regulatory domains. Moreover, proteins belonging to families classically described as chemoreceptors, such as odorant-binding proteins (OBPs) and chemosensory proteins (CSPs), were also highly abundant in the hemolymph of both sexes. Our data provide a comprehensive catalogue of A. aegypti hemolymph basal protein content, revealing numerous unexplored targets for future research on mosquito physiology and disease transmission. It also provides a reference for future studies on the effect of blood meal and infection on hemolymph composition.

Hemolymph

Proteome

Blood meal

10.1021/acs.jproteome.3c00918

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[Glycolipids of mammalian epidermis].

Sumiko Hamanaka Motoshi Suzuki

Epidermis (zoology)

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Postnatal brain development and neural cell differentiation modulate mitochondrial Bax and BH3 peptide-induced cytochrome c release

Cell Death and Differentiation (2003)

Brian M. Polster Courtney Robertson Cynthia J. Bucci Motoshi Suzuki Gary Fiskum

Mitochondrial apoptosis-induced channel

Apoptosome

10.1038/sj.cdd.4401158

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Citations (48)