Agnieszka Doroszuk

Wageningen University & Research

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i-10 index

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Co-Authors

Jan E. Kammenga

Wageningen University & Research

Bas J. Zwaan

Wageningen University & Research

Christina May

Canada's Michael Smith Genome Sciences Centre

Jaap Bakker

Leiden University Medical Center

Joost A. G. Riksen

Wageningen University & Research

Andrei‐José Petrescu

Romanian Academy

Mario de Bono

Institute of Science and Technology Austria

Joost van den Heuvel

Wageningen University & Research

Marcin W. Wojewodzic

Norwegian Institute of Public Health

Marcel Tijsterman

Leiden University

Cooperative Institutions

Bethesda University

Seattle University

Pasadena City College

Victoria University of Wellington

University of Auckland

Universidad de Salamanca

Advisory Board Company (United States)

Wageningen University & Research

United States Department of Justice

Science Oxford

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The effect of developmental nutrition on life span and fecundity depends on the adult reproductive environment in Drosophila melanogaster

Ecology and Evolution (2015)

Christina May Agnieszka Doroszuk Bas J. Zwaan

Summary Both developmental nutrition and adult nutrition affect life‐history traits; however, little is known about whether the effect of developmental nutrition depends on the adult environment experienced. We used the fruit fly to determine whether life‐history traits, particularly life span and fecundity, are affected by developmental nutrition, and whether this depends on the extent to which the adult environment allows females to realize their full reproductive potential. We raised flies on three different developmental food levels containing increasing amounts of yeast and sugar: poor, control, and rich. We found that development on poor or rich larval food resulted in several life‐history phenotypes indicative of suboptimal conditions, including increased developmental time, and, for poor food, decreased adult weight. However, development on poor larval food actually increased adult virgin life span. In addition, we manipulated the reproductive potential of the adult environment by adding yeast or yeast and a male. This manipulation interacted with larval food to determine adult fecundity. Specifically, under two adult conditions, flies raised on poor larval food had higher reproduction at certain ages – when singly mated this occurred early in life and when continuously mated with yeast this occurred during midlife. We show that poor larval food is not necessarily detrimental to key adult life‐history traits, but does exert an adult environment‐dependent effect, especially by affecting virgin life span and altering adult patterns of reproductive investment. Our findings are relevant because (1) they may explain differences between published studies on nutritional effects on life‐history traits; (2) they indicate that optimal nutritional conditions are likely to be different for larvae and adults, potentially reflecting evolutionary history; and (3) they urge for the incorporation of developmental nutritional conditions into the central life‐history concept of resource acquisition and allocation.

Life History Theory

Life span

10.1002/ece3.1389

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Citations (80)

Beyond induced mutants: using worms to study natural variation in genetic pathways

Trends in Genetics (2008)

Jan E. Kammenga Patrick C. Phillips Mario de Bono Agnieszka Doroszuk

Genetic screen

Model Organism

Caenorhabditis

Wild type

10.1016/j.tig.2008.01.001

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Citations (54)

Adaptation to developmental diet influences the response to selection on age at reproduction in the fruit fly

bioRxiv (Cold Spring Harbor Laboratory) (2018)

Christina May Joost van den Heuvel Agnieszka Doroszuk Katja M. Hoedjes Thomas Flatt

Abstract Experimental evolution (EE) is a powerful tool for addressing how environmental factors influence life-history evolution. While in nature different selection pressures experienced across the lifespan shape life histories, EE studies typically apply selection pressures one at a time. Here we assess the consequences of adaptation to three different developmental diets in combination with classical selection for early or late reproduction in the fruit fly Drosophila melanogaster . We find that the response to each selection pressure is similar to that observed when they are applied independently, but the overall magnitude of the response depends on the selection regime experienced in the other life stage. For example, adaptation to increased age at reproduction increased lifespan across all diets, however, the extent of the increase was dependent on the dietary selection regime. Similarly, adaptation to a lower calorie developmental diet led to faster development and decreased adult weight, but the magnitude of the response was dependent on the age-at-reproduction selection regime. Given that multiple selection pressures are prevalent in nature, our findings suggest that trade-offs should be considered not only among traits within an organism, but also among adaptive responses to different - sometimes conflicting - selection pressures, including across life stages.

Experimental Evolution

Adaptive response

Life History Theory

10.1101/496836

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Citations (0)

Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension

BMC Genomics (2012)

Agnieszka Doroszuk Martijs J. Jonker Nicolien Pul Timo M. Breit Bas J. Zwaan

While studying long-lived mutants has advanced our understanding of the processes involved in ageing, the mechanisms underlying natural variation in lifespan and ageing rate remain largely unknown. Here, we characterise genome-wide expression patterns of a long-lived, natural variant of Drosophila melanogaster resulting from selection for starvation resistance (SR) and compare it with normal-lived control flies (C). We do this at two time points representing middle age (90% survival) and old age (10% survival) respectively, in three adult diets (malnutrition, optimal food, and overfeeding). We found profound differences between Drosophila lines in their age-related expression. Most of the age-associated changes in normal-lived flies were abrogated in long-lived Drosophila. The stress-related genes, including those involved in proteolysis and cytochrome P450, were generally higher expressed in SR flies and showed a smaller increase in expression with age compared to C flies. The genes involved in reproduction showed a lower expression in middle-aged SR than in C flies and, unlike C flies, a lack of their downregulation with age. Further, we found that malnutrition strongly affected age-associated transcript patterns overriding the differences between the lines. However, under less stressful dietary conditions, line and diet affected age-dependent expression similarly. Finally, we present lists of candidate markers of ageing and lifespan extension. Our study unveils transcriptional changes associated with lifespan extension in SR Drosophila. The results suggest that natural genetic variation for SR and lifespan can operate through similar transcriptional mechanisms as those of dietary restriction and life-extending mutations.

10.1186/1471-2164-13-167

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Citations (53)

Evaluation of information indices as indicators of environmental stress in terrestrial soils

Ecological Modelling (2007)

Maria A. Tobor‐Kapłon Remko Holtkamp Ursula M. Scharler Agnieszka Doroszuk Frans J.A. Kuenen

Terrestrial ecosystem

10.1016/j.ecolmodel.2007.04.022

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Citations (12)

Editorial Board

Trends in Genetics (2008)

Treasa Creavin Sara B. Cullinan Ellie Carr Suado Nur Lara Crow

10.1016/s0168-9525(08)00031-0

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Citations (0)

Rapid Divergence of Genetic Variance‐Covariance Matrix within a Natural Population

The American Naturalist (2008)

Agnieszka Doroszuk Marcin W. Wojewodzic Gerrit Gort Jan E. Kammenga

The matrix of genetic variances and covariances (G matrix) represents the genetic architecture of multiple traits sharing developmental and genetic processes and is central for predicting phenotypic evolution. These predictions require that the G matrix be stable. Yet the timescale and conditions promoting G matrix stability in natural populations remain unclear. We studied stability of the G matrix in a 20‐year evolution field experiment, where a population of the cosmopolitan parthenogenetic soil nematode Acrobeloides nanus was subjected to drift and divergent selection (benign and stress environments). Selection regime did not influence the level of absolute genetic constraints: under both regimes, two genetic dimensions for three life‐history traits were identified. A substantial response to selection in principal components structure and in general matrix pattern was indicated by three statistical methods. G structure was also influenced by drift, with higher divergence under benign conditions. These results show that the G matrix might evolve rapidly in natural populations. The observed high dynamics of G structure probably represents the general feature of asexual species and limits the predictive power of G in phenotypic evolution analyses.

Genetic drift

Genetic architecture

Divergence (linguistics)

Matrix (chemical analysis)

Stabilizing selection

Quantitative Genetics

Genetic divergence

10.1086/527478

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Citations (74)

Adaptation to developmental diet influences the response to selection on age at reproduction in the fruit fly

Journal of Evolutionary Biology (2019)

Christina May Joost van den Heuvel Agnieszka Doroszuk Katja M. Hoedjes Thomas Flatt

Abstract Experimental evolution ( EE ) is a powerful tool for addressing how environmental factors influence life‐history evolution. While in nature different selection pressures experienced across the lifespan shape life histories, EE studies typically apply selection pressures one at a time. Here, we assess the consequences of adaptation to three different developmental diets in combination with classical selection for early or late reproduction in the fruit fly Drosophila melanogaster . We find that the response to each selection pressure is similar to that observed when they are applied independently, but the overall magnitude of the response depends on the selection regime experienced in the other life stage. For example, adaptation to increased age at reproduction increased lifespan across all diets; however, the extent of the increase was dependent on the dietary selection regime. Similarly, adaptation to a lower calorie developmental diet led to faster development and decreased adult weight, but the magnitude of the response was dependent on the age‐at‐reproduction selection regime. Given that multiple selection pressures are prevalent in nature, our findings suggest that trade‐offs should be considered not only among traits within an organism, but also among adaptive responses to different—sometimes conflicting—selection pressures, including across life stages.

Experimental Evolution

Life History Theory

Adaptive response

10.1111/jeb.13425

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Citations (25)

A Caenorhabditis elegans Wild Type Defies the Temperature–Size Rule Owing to a Single Nucleotide Polymorphism in tra-3

PLoS Genetics (2007)

Jan E. Kammenga Agnieszka Doroszuk Joost A. G. Riksen Esther Hazendonk Laurenţiu Spiridon

Ectotherms rely for their body heat on surrounding temperatures. A key question in biology is why most ectotherms mature at a larger size at lower temperatures, a phenomenon known as the temperature-size rule. Since temperature affects virtually all processes in a living organism, current theories to explain this phenomenon are diverse and complex and assert often from opposing assumptions. Although widely studied, the molecular genetic control of the temperature-size rule is unknown. We found that the Caenorhabditis elegans wild-type N2 complied with the temperature-size rule, whereas wild-type CB4856 defied it. Using a candidate gene approach based on an N2 x CB4856 recombinant inbred panel in combination with mutant analysis, complementation, and transgenic studies, we show that a single nucleotide polymorphism in tra-3 leads to mutation F96L in the encoded calpain-like protease. This mutation attenuates the ability of CB4856 to grow larger at low temperature. Homology modelling predicts that F96L reduces TRA-3 activity by destabilizing the DII-A domain. The data show that size adaptation of ectotherms to temperature changes may be less complex than previously thought because a subtle wild-type polymorphism modulates the temperature responsiveness of body size. These findings provide a novel step toward the molecular understanding of the temperature-size rule, which has puzzled biologists for decades.

Ectotherm

Wild type

Epistasis

10.1371/journal.pgen.0030034

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Citations (113)

A C. elegans Wild-type Defies the Temperature-size Rule due to a Single Nucleotide Polymorphism in tra-3

PLoS Genetics (2005)

Jan E. Kammenga Agnieszka Doroszuk Joost A. G. Riksen Esther Hazendonk Laurentio Spiridon

10.1371/journal.pgen.0030034.eor

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Citations (0)