Tze Fang Wong

Novartis (Japan)

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Estrogen formulations and beauty care practices in Japanese women

International Journal of Women s Health (2012)

Takashi Takeda Yaegashi Kitamura Tze Fang Wong

Purpose: Traditionally, oral estrogens have been used for hormone replacement therapy. However, in Japan, additional estrogen formulations have been used, including transdermal patches and transdermal gels. The latter have a unique commonality with cosmetics because both of them are applied to the skin. Beauty care is one of the most important lifestyle factors for women, and it has been reported that the amount of attention paid to beauty care has an effect in determining whether or not women will choose to undergo HRT during menopause. Therefore, our study focused on estrogen formulations and beauty care practices. Patients and methods: Fifty women who use hormone replacement therapy were recruited from the outpatient clinic of Tohoku University Hospital. They were treated with oral conjugated estrogen (n = 11), transdermal 17ß -estradiol patch (n = 11), and transdermal 17ß-estradiol gel (n = 28). They completed a questionnaire to assess their lifestyle (beauty care practices and exercise habits) and their compliance. The transdermal gel users were further interviewed about their subjective impressions regarding “smell”, “sticky feeling”, “spreadability”, and “irritation” on the skin using a five-grade scale. Results: There were no differences in the usability of medicines and patient compliance among the estrogen formulations. We observed a positive tendency between the level of beauty care and transdermal gel use ( P = 0.0645, ordinary logistic regression analysis). The gel users placed top priority on a lack of “sticky feeling” but the subjective impression regarding “sticky feeling” was worst among the four factors ( P < 0.01, Steel–Dwass test). Correspondence analysis showed that the subjective impressions of transdermal gel corresponding to usability in the range of “moderate” to “very good” and “sticky feeling” greatly affected the usability of the formulation. Conclusion: These results suggest that the level of attention to beauty care plays some role in the choice of estrogen formulations. Keywords: HRT, estrogen, transdermal gel, cosmetics, subjective impression

Beauty

10.2147/ijwh.s28368

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Citations (1)

Epigallocatechin-3-gallate potentiates curcumin’s ability to suppress uterine leiomyosarcoma cell growth and induce apoptosis

International Journal of Clinical Oncology (2012)

Akiko Kondo Takashi Takeda Bin Li Kenji Tsuiji Mari Kitamura

10.1007/s10147-012-0387-7

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Citations (24)

Management of primary immune thrombocytopenia in a real-world setting in Japan: eltrombopag versus corticosteroids

International Journal of Hematology (2021)

Tze Fang Wong Renata Majewska Yoshiaki Tomiyama

Eltrombopag

Romiplostim

Hematology

10.1007/s12185-021-03149-z

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Citations (3)

Curcumin targets the AKT–mTOR pathway for uterine leiomyosarcoma tumor growth suppression

International Journal of Clinical Oncology (2013)

Tze Fang Wong Takashi Takeda Bin Li Kenji Tsuiji Akiko Kondo

Surgical oncology

10.1007/s10147-013-0563-4

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Citations (23)

FLASH SESSION ORAL & POSTER PRESENTATION

EP Europace (2009)

R. Alkmim Teixeira M. Martinelli Filho Eduardo Ferreira Borba Eloísa Bonfá S. A. D. Nishioka

Presentation (obstetrics)

10.1093/europace/euq199

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The antidiabetic drug metformin inhibits uterine leiomyoma cell proliferation via an AMP-activated protein kinase signaling pathway

Gynecological Endocrinology (2012)

Bin Li Takashi Takeda Kenji Tsuiji Akiko Kondo Mari Kitamura

Uterine leiomyomas are the most common gynecological benign tumors and greatly affect reproductive health and wellbeing. Metformin is the most widely used antidiabetic drug in the world, and there is increasing evidence of a potential efficacy of this agent as an anticancer drug. In order to understand metformin's anti-tumorigenic potential better, in this study, we investigated the inhibitory effect of metformin and expression of key targets of metformin cell signaling in leiomyoma cells. Cell proliferation was assessed after exposure to metformin. Apoptosis was assessed by western blotting for cleaved-PARP and TUNEL staining. The expressions of phosphorylated AMPK and phosphorylated S6 were determined by western blotting. Metformin potently inhibited ELT-3 cell proliferation in a dose-dependent manner. Western blotting analysis demonstrated that metformin induced phosphorylation of AMPK and the inhibitory effect was attenuated with AMPK inhibitor, compound C. In parallel, treatment with metformin decreased phosphorylation of S6 protein. These experimental findings show that metformin is a potent inhibitor of cell proliferation in leiomyoma cells. This effect is mediated by AMPK activation and subsequent inhibition of the mTOR pathway. Thus, this study provides a possible mechanism of the action of metformin in the inhibition of leiomyoma cell growth.

Uterine Leiomyoma

10.3109/09513590.2012.706668

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Citations (16)

Abstract 316: Keap1 and Nrf2 genetic mutations and polymorphisms: Associations with clinical outcome in endometrial cancer

Cancer Research (2011)

Tze Fang Wong Kousuke Yoshinaga Yasutake Monma Kiyoshi Ito Hitoshi Niikura

Abstract Background: Constitutive activation and increased expression of Nrf2 as a result of oncogenic mutations or other endogenous factors that cause derepression of Nrf2 by its cytosolic inhibitor, Keap1, contribute to tumor resistance to adjuvant treatment. As endometrial cancer generally has a lower response rate to adjuvant treatment, Keap1 and Nrf2 genes were sequenced to investigate their roles in endometrial cancer. Materials and Methods: Tumor specimens from 105 individuals with endometrioid endometrial adenocarcinoma (Type I endometrial cancer) were sequenced. The specimens comprised 44 well-differentiated (FIGO grade 1), 38 moderately differentiated (FIGO grade 2) and 23 poorly differentiated (FIGO grade 3) tumors. Statistical analyses using the Fisher's exact test, Pearson's Chi-square test and Cox proportional hazards model were used to investigate the association of genetic mutations and haplotypes with patients’ annotated clinicopathologic characteristics. Results: A total of ten novel Keap1 mutations were found in nine individuals, and two novel Nrf2 mutations were found in three individuals. One patient had two simultaneous Keap1 mutations, whereas two patients had the same type of Nrf2 genetic mutation. Two single nucleotide polymorphisms, rs1048290 and rs11545829 were found in high frequency in the present cohort. The non-synonymous genetic mutations and rs11545829 were not associated with patients’ clinicopathologic characteristics. In the adjuvant treatment subgroup, the rs1048290 c.1413C/G genotype was significantly associated with a better progression-free survival (hazard ratio, 0.25; 95% confidence interval [CI], 0.068 to 0.94; P=0.041). On multivariate analysis, rs1048290 was an independent prognostic factor for progression-free survival (hazard ratio, 0.16; 95% CI, 0.036 to 0.69; P=0.014). Conclusion: Keap1 single nucleotide polymorphism rs1048290 may be a potential biomarker that enables individualized therapy using cytotoxic adjuvant treatment in endometrial cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 316. doi:10.1158/1538-7445.AM2011-316

10.1158/1538-7445.am2011-316

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Twin pregnancy complicated with bowel strangulation

BMJ Case Reports (2014)

Tze Fang Wong Shunichi Imai Masato Tomita

A 31-year-old primigravida at 35 weeks of gestation with twins who had no prior abdominal surgical history presented with worsening nausea, vomiting and abdominal pain. Initial screening ruled out obstetrical causes that may threaten the pregnancy. Twelve hours after the onset of symptoms, a transabdominal ultrasound revealed abdominal free fluid. A CT scan confirmed strangulated ileus involving the small bowels. Owing to non-reassuring fetal status in one of the twins, an emergency caesarean section and subsequent laparotomy were performed. The first twin presenting with fetal distress had to be resuscitated postdelivery but recovered uneventfully and met all developmental milestones by 3 months of age. The mother had a strangulated small bowel that had to be resected. She had an uncomplicated postsurgical course and gained full bowel function prior to discharge from the hospital.

Ileus

Abdominal pregnancy

Twin Pregnancy

10.1136/bcr-2014-205727

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Citations (1)

ISO-5 Mutation Analyses of Keap1 and Nrf2 Genes in Endometrial Cancer(Group1 Oncology,International Session: Oral Presentation)

日本産科婦人科學會雜誌 (2010)

Tze Fang Wong Kosuke Yoshinaga Hitoshi Niikura Kiyoshi Ito Nobuo Yaegashi

Presentation (obstetrics)

Gynecologic oncology

Source

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Guidelines for office gynecology in Japan: Japan Society of Obstetrics and Gynecology and Japan Association of Obstetricians and Gynecologists 2011 edition

Journal of Obstetrics and Gynaecology Research (2012)

Takashi Takeda Tze Fang Wong Tomoko Adachi Kiyoshi Ito Shigeki Uehara

Abstract Gynecology in the office setting is developing worldwide. Clinical guidelines for office gynecology were first published by the Japan Society of Obstetrics and Gynecology and the Japan Association of Obstetricians and Gynecologists in 2011. These guidelines include a total of 72 clinical questions covering four areas (Infectious disease, Malignancies and benign tumors, Endocrinology and infertility, and Healthcare for women). These clinical questions were followed by several answers, backgrounds, explanations and references covering common problems and questions encountered in office gynecology. Each answer with a recommendation level of A, B or C has been prepared based principally on evidence or consensus among Japanese gynecologists.These guidelines would promote a better understanding of the current standard care practices for gynecologic outpatients in Japan.

10.1111/j.1447-0756.2012.01858.x

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Citations (16)