Francisco Lúzio de Paula Ramos

Instituto Evandro Chagas

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Talita Antônia Furtado Monteiro

Instituto Evandro Chagas

Igor Brasil Costa

Instituto Evandro Chagas

Rita Catarina Medeiros Sousa

Instituto Evandro Chagas

Iran Barros Costa

Instituto Evandro Chagas

Ana Yecê das Neves Pinto

Instituto Evandro Chagas

Amaury Bentes Cunha Freire

Instituto Evandro Chagas

Arnaldo Jorge Martins Filho

Instituto Evandro Chagas

Beatriz Monteiro Rodrigues Coelho

Instituto Evandro Chagas

José Luiz Monteiro

Centro Universitário do Pará

Thais Letícia dos Santos Corrêa

Instituto Federal de Educação, Ciência e Tecnologia do Pará

Cooperative Institutions

Instituto Evandro Chagas

Ministério da Saúde

Universidade Federal do Pará

Ministério da Saúde

Universidade do Estado do Pará

Fundação Oswaldo Cruz

Centro Universitário do Pará

Secretaria da Saúde

Fundação Saúde

Manchester Metropolitan University

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Epidemiological risk factors associated with primary infection by Epstein–Barr virus in HIV-1-positive subjects in the Brazilian Amazon region

Scientific Reports (2021)

Leonn Mendes Soares Pereira Eliane dos Santos França Iran Barros Costa Igor Tenório Lima Amaury Bentes Cunha Freire

Abstract To identify the prevalence and risk factors for primary Epstein–Barr virus (EBV) infection in human immunodeficiency virus (HIV)-1-positive adult treatment-naïve patients between January 2018 and December 2019 in a state of the Brazilian Amazon region. A total of 268 HIV-1 positive patients and 65 blood donors participated in the study. Epidemiological data were obtained from medical records and through a designed questionnaire. EBV infection was screened by the semiquantitative detection of anti-viral capsid antigen (VCA) EBV IgM and IgG, followed by molecular detection of the EBNA-3C gene. The plasma viral loads of HIV-1 and EBV were quantified using a commercial kit. The prevalence of primary coinfection was 7.12%. The associated risk factors were education level, family income, history of illicit drug use and sexually transmitted infections, homosexual contact and condom nonuse. Approximately 58.5% had late initiation of highly active antiretroviral therapy, which influenced the risk of HIV-EBV 1/2 multiple infection (odds ratio (OR): 4.76; 95% CI 1.51–15.04) and symptom development (p = 0.004). HIV viral load was associated with patient age (OR: 2.04; 95% CI 2.01–2.07; p = 0.026) and duration of illicit drug use (OR: 1.57; 95% CI 1.12–2.22; p = 0.0548). EBV viral load was associated with younger age (OR: 0.82; 95% CI 0.79–1.03; p = 0.0579). The replication of both viruses was associated with symptom development (HIV = OR: 2.06; 95% CI 1.22–3.50; p = 0.0073; EBV = OR: 8.81; 95% CI 1–10; p = 0.0447). The prevalence of HIV/EBV coinfection was lower than that observed in other studies, and social vulnerability and promiscuous sexual behavior were associated risk factors. A long time of HIV-1 infection, without therapy, influenced the risk of coinfection and disease progression. The viral loads of both viruses may be associated with some epidemiological aspects of the population.

10.1038/s41598-021-97707-4

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Reducing malpractice exposure.

PubMed (2003)

Francisco Lúzio de Paula Ramos

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GENE EBNA3C: TYPES OF INFECTION BY EBV (EBV1 and EBV2), CORRELATION WITH CLINICAL AND BIOCHEMICAL PARAMETERS (AST, ALT and GGT) IN INDIVIDUALS WITH INFECTIOUS MONONUCLEOSIS OF THE METROPOLITAN AREA OF BELÉM, PARÁ, IN THE PERIOD OF 2005-2016

Research Square (Research Square) (2019)

Talita Antônia Furtado Monteiro Iran Barros Costa Igor Brasil Costa Thais Letícia dos Santos Corrêa Beatriz Monteiro Rodrigues Coelho

Abstract Two types of EBV (EBV1 and 2) have been shown to infect humans. Detect the types of EBV that cause infectious mononucleosis and correlate these viral types with biochemical parameters (AST, ALT and GGT) on in the metropolitan region of Belém, 2005 to 2016. A total 76 cases of infectious mononucleosis, processed the Instituto Evandro Chagas, Ananindeua, Brazil. Evaluated by PCR used primers the region EBNA 3C. EBV1 infection was observed in 71.1% (54/76) of individuals, among whom those > 14 years constituted 66.7% (36/54), the average age was 23 years, and the number of women infected was higher (61.1% [33/54]) than that of men (38.9%[21/54]). The symptoms/clinical signs observed in infection by EBV1 were cervical lymphadenopathy in 64.8% (35/54), fever in 63% (34/54), headache and arthralgia in 20.3% (11/54), and exanthema in 18.5% (10/54). Infection by EBV2 was observed in only 17.1% (13/76) of cases. Co-infection by EBV1 and EBV2, most frequently showing symptoms of fever and cervical lymphadenopathy, occurred in 66.7 (6/9) and 55.6% (5/9) of individuals. EBV1 was predominant in 71% of clinical cases of infectious mononucleosis. Correlation of biochemical parameters in infection by EBV1, EBV2, and co-infection by EBV1/2 revealed a statistically significant difference in mean changes of EBV1 in individuals older than 14 years.

Mononucleosis

10.21203/rs.2.10515/v2

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Triatomine home invasions in active foci of Chagas disease in Abaetetuba, Pará, Brazil

Transactions of the Royal Society of Tropical Medicine and Hygiene (2021)

Bruna Daniele Lisboa Mota Vera da Costa Valente Francisco Lúzio de Paula Ramos Sebastião Aldo da Silva Valente Ana Yecê das Neves Pinto

Chagas disease is a parasitic infection with high re-emergence rates in some Amazon regions. The main vectors of Trypanosoma cruzi are haematophagous insects, the triatomines. Only a few reports are available about the occurrence of these wild vectors and their contact with the inhabitants of the riverside regions of the Amazon. This study describes the unusual behaviour of the triatomines that have invaded the homes of the residents of Abaetetuba, the city that has the second highest number of cases of Chagas disease.Two cross-sectional studies were conducted using sero-epidemiological surveys of the inhabitants of Abaetetuba with registered triatomine home invasions. The frequencies of the variables of interest were analysed using Epi Info version 7.2.In 2014 and 2017, 145 persons registered home invasions of triatomines in their domiciles and 16.55% reported having been bitten by insects. The environmental features described indicated potential conditions for the persistence of the parasite's life cycle. Of the enrolled inhabitants, 0.47% were positive for immunoglobulin G anti-T. cruzi antibodies.Home invasions of triatomines were confirmed in two periods, with a description of unusual behaviour for the genus Rhodnius. The use of serological surveillance in human populations at risk of this occurrence may constitute a new tool for the early detection of silent infections.

Chagas Disease

Triatominae

Rhodnius

Entomology

Triatoma

10.1093/trstmh/trab057

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Abordagem multidisciplinar em área de elevada endemicidade de doenças por transmissão fecal oral

Gilberta Bensabath Samyr Cavalero Carmem Oliveira Manoel do Carmo Pereira Soares Francisco Lúzio de Paula Ramos

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Epidemia de Febre Tifóide na localidade Cipoal, município de Óbidos, Estado do Pará - análise preliminar

Francisco Lúzio de Paula Ramos Jânia Rodrigues de S Oliveira José Caetano Lima Silva

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Reação cruzada nos testes sorológicos entre doença de Chagas e leishmaniose visceral em regiões endêmicas para ambas as doenças

Revista Pan-Amazônica de Saúde (2015)

Haroldo José de Matos Ana Yecê das Neves Pinto Antônio Marcos Mota Miranda Fernanda Lúcia Cardoso Silva Francisco Lúzio de Paula Ramos

Reação cruzada nos testes sorológicos entre doença de Chagas e leishmaniose visceral em regiões endêmicas para ambas as doençasReacción cruzada en las pruebas serológicas entre

10.5123/s2176-62232015000100007

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Phenotypic and genotypic characterization of Serratia marcescens from a Neonatal Unit in Belém, Pará State, Brazil

Revista Pan-Amazônica de Saúde (2010)

Raimundo Gladson Corrêa Carvalho Irna Carla do Rosário Souza Carneiro Marcelo Sena Pinheiro Surama da Costa Pinheiro Paulo Sérgio Roffe Azevedo

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Salmonella serovars of human origin identified in Pará State, Brazil from 1991 to 2008

LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (2010)

Edvaldo Carlos Brito Loureiro Nathalia Danielly Borges Marques Francisco Lúzio de Paula Ramos Eliane Moura Falavina dos Reis Dália dos Prazeres Rodrigues

Salmonellosis presents a cosmopolitan distribution and affects all age groups, not only in developed countries, but also in developing ones. This study aimed to identify the serovars of Salmonella isolated from human infections occurring in 43 areas of Para State from 1991 to 2008. Eight hundred and ninety samples of Salmonella isolated in coprocultures and blood cultures were analyzed, including 55 isolations of S. Typhi from feces and blood of symptomatic individuals, simultaneously. The cases of Salmonella infections were distributed into 13 serogroups. The majority of them were in group O:9 (68.1%), and 47 serovars of Salmonella were identified, including S. Typhi (58.9%), S. Enteritidis (5.4%) and S. Saintpaul (2.5%). S. Typhi was the most prevalent (58.9%) among the 47 identified serovars, which demonstrates that typhoid fever is a serious public health problem in northern Brazil and requires increased attention from health agencies regarding epidemiological and environmental surveillance as effective measures for its prevention and control.

Salmonella enteritidis

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Vírus da varicela-zoster: identificação dos genótipos em casos de varicela e herpes-zoster nos Municípios de Ananindeua, Belém e Marituba, Estado do Pará, Brasil

Revista Pan-Amazônica de Saúde (2016)

Marcos Rogério Menezes da Costa Talita Antônia Furtado Monteiros Alexandre da Costa Linhares Igor Brasil Costa Jane Haruko Lima Kaiano

Este é um estudo do tipo transversal, em que o critério clínico para inclusão das amostras foi a suspeita clínica e/ou aparecimento dos sintomas da varicela ou herpes-zoster para identificação dos genótipos do vírus da varicela-zoster (VVZ), por meio das técnicas de reação em cadeia da polimerase (PCR) e sequenciamento, com posterior pesquisa de polimorfismo de nucleotídeo único (SNP). De novembro de 2008 a março de 2012, foram coletadas 93 amostras (85 casos de varicela e oito de herpes-zoster) de swab nasal, oral e de secreção de vesículas rompidas em vários sítios anatômicos (49 de indivíduos do sexo masculino e 44 do feminino). As estirpes Dumas e Oka parental foram incluídas como referência padrão dos genótipos europeu (classe 1 ou 3) e japonês (classe 2), respectivamente. Estirpes com variabilidade no SNP foram classificadas dentro de um grupo de genótipo denominado mosaico (classe 5). As classes 1 ou 3 foram identificadas em 11 amostras do VVZ, nove casos de varicela e dois casos de herpes-zoster, enquanto que duas amostras apresentaram o genótipo de classe 5, ambos casos de varicela. O genótipo classe 1 ou 3 foi encontrado nos Municípios de Ananindeua, Belém e Marituba, Estado do Pará, Brasil, sendo que o genótipo classe 5 apenas em Ananindeua. A PCR foi sensível em 13 amostras de material direto de vesículas, enquanto que em amostras de saliva não se obteve sucesso.

10.5123/s2176-62232016000300004

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