G Colella

University of Campania "Luigi Vanvitelli"

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Giuseppina Campisi

University of Palermo

Gianpaolo Tartaro

University of Campania "Luigi Vanvitelli"

Raffaele Rossiello

University of Naples Federico II

A Lanza

University of Salerno

Domenico Compilato

University of Palermo

Tartaro Gp

University of Pisa

Antonio Vicidomini

International Centre for Genetic Engineering and Biotechnology

A Itro

University of Campania "Luigi Vanvitelli"

Rosangela Cannavale

University of Turin

G Aiale

Cooperative Institutions

University of Naples Federico II

University of Campania "Luigi Vanvitelli"

University of Foggia

University of Palermo

University of Bari Aldo Moro

Istituti di Ricovero e Cura a Carattere Scientifico

Sapienza University of Rome

University of Turin

National Medical Research Center of Dentistry and Maxillofacial Surgery

University of Melbourne

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Efficacy of a Spray Compound Containing a Pool of Collagen Precursor Synthetic Amino Acids (L-Proline, L-Leucine, L-Lysine and Glycine) Combined with Sodium Hyaluronate to Manage Chemo/Radiotherapy-Induced Oral Mucositis: Preliminary Data of an Open Clinical Trial

International Journal of Immunopathology and Pharmacology (2010)

G Colella R. Cannavale Antonio Vicidomini Giulia Rinaldi Domenico Compilato

Oral mucositis (OM) is a very frequent and potentially severe complication experienced by patients receiving chemotherapy and/or radiotherapy, which often leads to significant morbidity and mortality, and decreased quality of life, and is very costly. Despite its severity and prevalence, there is no standard recognised management today. The aim of this open clinical trial is to evaluate the efficacy and compliance of a new spray compound containing sodium hyaluronate (SH) and a pool of collagen precursor amino acids (AAs) combined with sodium hyaluronate (SH) to manage radio/chemotherapy-induced OM. Twenty-seven consecutive patients with OM were treated according to the manufacturer's instructions. At time TO (baseline — before intervention), we evaluated the following parameters: (i) pain score (by linear visual analogue scale; 0–100) and (ii) severity of OM scored according to WHO Mucositis scale. The treatment efficacy was evaluated on i) pain score, ii) clinical resolution index (CRI) and iii) patient compliance at times T01 (after 2 hours), T1 (after 24 hours), T2 (after 72 hours), T3 (after 7 days) and T4 (after 14 days). Results showed that painful symptoms were significantly reduced after only 2 hours of spray administration compared with baseline measurements ( p<0.0001; z=−4.541). A progressive reduction of pain through the 2 weeks was also noted ( p<0.0001). Patient lesions treated with SH-AAs-based spray also significantly improved after 72 hours of treatment ( p=0.0051; z=−2.803). During the two-week observation, all patients significantly improved from the baseline ( p<0.0001) and progressively ameliorated their ability to swallow foods and liquids. The compliance of all patients to the product was very good, and at the end of the study there were no adverse effects. The results suggest that the SH-AAs-based spray accelerates lesion healing and above all helps to manage mucositis pain, especially in terms of immediate pain relief (after 2 hours from application). Although further randomized controlled studies are recommended, our findings suggest that frequent applications of this spray may offer rapid and effective pain management, aiding faster mucosal wound healing.

Mucositis

Sodium hyaluronate

10.1177/039463201002300113

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Citations (33)

[Central giant cell tumor of the jaw bone].

PubMed (1985)

Marco Giudice G Colella Angela Marra G Aiale

Jaw bone

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Rapid identification ofCandidaspecies in oral rinse solutions by PCR

Journal of Clinical Pathology (2007)

Giorgio Liguori Angela Lucariello G Colella Antonio De Luca Paolo Marinelli

To determine the sensitivity and specificity of a multiplex PCR assay for the contemporary identification of major species involved in oral candidiasis, without extraction and purification of DNA from the samples under investigation; and evaluation of this method in comparison with routine phenotypic culture identification.78 oral rinse solutions were collected. The concentrated oral rinse technique was used for a quantitative and qualitative study. Research and identification of Candida spp, with routine phenotypic culture identification (germ-tube test in serum at 37 degrees C for 3 hours and sugar assimilation strip analysis), were performed. Each sample was analysed with multiplex PCR directly on oral rinse solution. Samples giving discrepant results between routine phenotypic and PCR identification methods were resubcultured on CHROMagar Candida plates. The fungus-specific primers ITS1, ITS2, CA3, and CA4 were used. For the identification of other species (C kefyr, C famata and C dubliniensis), ITS1F, ITS1K, and ITS2D primers were designed.Multiplex PCR correctly identified all samples, including those with single species, or with mixed species, negative samples and positive samples which appeared to be negative from routine phenotypic methods.This multiplex PCR assay provides a rapid alternative to the conventional culture based technique for the identification and speciation of the most frequently isolated Candida species. The absence of an extraction method made identification of 10 species possible in a few hours.

Identification

Candida infections

10.1136/jcp.2006.040782

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Citations (54)

Kaposi's sarcoma of the tongue associated with median rhomboid glossitis in a non-AIDS patient. A case report.

PubMed (2004)

Raffaele Rossiello G Colella R. A. Satriano A Vozza Luigi Rossiello

Kaposi's sarcoma (KS) of the tongue is extremely rare in immunocompetent patients. We report a case of KS of the tongue associated with a median rhomboid glossitis. The main clinical, pathological and immunohistochemical features allowed the differential diagnosis.

Glossitis

Tongue Neoplasm

Tongue disease

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[Traumatic neuroma of the great auricular nerve. A clinical case].

PubMed (2002)

G Colella C Borriello A Lanza Raffaele Rossiello G Siniscalchi

A clinical case of neuroma resulting from an amputation which occurred following parotid surgery is reported. The present paper discusses the importance of differential diagnosis relating to this pathology and the surgical techniques that may contribute to setting a limit on its onset. Traumatic neuroma is a possible complication of parotid surgery together with motor deficiencies and Frey's syndrome and the less frequent salivary fistulas. It may also occur following oncological or plastic-reconstructive surgery. During parotidectomy operations, section of the great auricular nerve may be required to facilitate access to the parotid region. This manoeuvre may, however, also be associated with the onset of a neuroma during a time period varying from 2 to 10 years, according to the various authors who have examined the subject. The laterocervical tumefaction associated with neuroma poses a number of diagnostic problems as it has to be differentiated from a likely relapse or possibly from more complex inflammatory or metastatic lymphnodal pathology. A correct clinical and diagnostic multidisciplinary approach is fundamental if the pathology is to be classified in the right way and contributes to alleviating a state of mental unease in the patient that is associated with the sudden appearance of the tumefaction. Sectioning the nervous trunk by means of thermocautery and its subsequent sinking below the main trunk of the sternocleidomastoid muscle, are simple surgical manoeuvres that are useful for preventing the onset of traumatic neuroma.

Neuroma

Parotidectomy

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Citations (4)

[Aphthosis of the oral cavity: therapeutic prospectives].

PubMed (1996)

G Colella Grimaldi Pl Tartaro Gp

After analysing of recurrent aphthous stomatitis the clinical and morphological aspects, the authors consider various therapeutic possibilities. They underline the relationship between therapy and clinical aspects of the pathology.

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[The role of maxillofacial prosthesis in the prosthetic rehabilitation for socio-functional recovery of oncological patients: a particular type of dento-maxillary prosthesis].

PubMed (1988)

Michele Giudice Alice La Marra G Colella G Aiale

Dental prosthesis

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Oral self-injuries: Clinical findings in a series of 19 patients

Medicina oral, patología oral y cirugía bucal (2014)

Rosangela Cannavale A Itro Giuseppina Campisi Domenico Compilato G Colella

Self-injury (SI) is defined as a behavioral disturbance consisting of a deliberate harm to one's own body without suicidal intent, it is not uncommon and ranges in severity from simple nail-biting to more extreme forms of self-mutilation. The head neck region may be the target of such lesions. SI is associated with several medical conditions, of which it can represent the first clinical sign. Aim of this paper is to describe a series of oral SI, giving special emphasis to the clinical findings, etiology and the management of lesions.A total of 19 patients with oral SI were prospectively examined; attention was paid to the occurrence and characterization of oral lesions. The management of the lesion also varied depending on the patient medical history, on the etiology of the psychiatric behavior, and on the severity, frequency, and method of inflicting injury. Periodic examinations were performed (after two weeks, three months and six months) and registered.All the patients healed gradually and healing was conditioned by the disease underlying. The treatment consisted of behavior modification in 11 cases, pharmacological treatment in 11 cases, psychotherapy in 2 cases, mouth guard in 9 cases, surgery in 2 cases, extractions in 1 case.Oral SI are uncommon in the clinical practice. They may be associated with a known disease or may be the consequence of this, but often they may be the first sign of a psychiatric disorder.

Etiology

Accidental

Deliberate self-harm

10.4317/medoral.19643

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Citations (25)

Mandibular Metastasis from Papillary Thyroid Carcinoma a Case Report

Tumori Journal (2003)

G Colella Rosita Capone Salvatore Cappabianca

Mandibular metastases from papillary carcinoma of the thyroid are very uncommon. Whereas follicular carcinoma metastasizes hematogenously, papillary carcinoma usually remains intrathyroidal and tends to metastasize only to regional nodes. A case of metastatic papillary carcinoma to the mandible is presented here. The metastasis arose five years after a right thyroid lobectomy and isthmectomy for lesions diagnosed as papillary carcinoma. Though relatively rare, thyroid tumors metastatic to the mandible should be included in the differential diagnosis of tumors in the oral region because early detection and treatment of these metastatic lesions may result in long-term survival.

Mandible (arthropod mouthpart)

10.1177/030089160308900422

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Citations (17)

[Focal disease: history and review of the literature].

PubMed (1984)

Stroffolini Fa Annachiara Marra G Colella A Itro P Troisi

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