Jesper Friis Petersen

Copenhagen University Hospital

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Tine Wrønding

Hvidovre Hospital

Maiken Hemme Bro‐Jørgensen

University of Copenhagen

Boyang Ji

Shanghai Jiao Tong University

Letizia Amato

Hvidovre Hospital

Ellen Løkkegaard

Zealand University Hospital

Louise Ambye

Hvidovre Hospital

Mette Marie Babiel Schmidt Petersen

Hvidovre Hospital

Iben Bache

Copenhagen University Hospital

Tanja Schlaikjær Hartwig

Hvidovre Hospital

Eva R. Hoffmann

University of Copenhagen

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Copenhagen University Hospital

University of Copenhagen

Hvidovre Hospital

Rigshospitalet

Herlev Hospital

Zealand University Hospital

BioInnovation Institute

Novo Nordisk Foundation

Statistics Denmark

Engineering Service Center und Handel (Germany)

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Treatment of threatened pregnancy loss

Ugeskrift for Læger (2025)

Anna Maria Kastner Christoph Lindner Ida Behrendt-Møller Fie Pilsgaard Maria Dorn‐Rasmussen

Vaginal bleeding in the first trimester indicates threatened pregnancy loss and may be due to progesterone insufficiency. Vaginal micronised progesterone (400 mg vaginal tablets twice a day) can increase live birth rates and is recommended for women with threatened pregnancy loss and a history of three or more losses (number needed to treat = 8). It should be considered for women with one (number needed to treat = 20) or two losses. Insufficient data exist to recommend other treatments such as tranexamic acid and bed rest.

Vaginal bleeding

Rest (music)

Threatened abortion

10.61409/v07240474

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Cell-Free Fetal DNA for Genetic Evaluation in Copenhagen Pregnancy Loss Study (COPL): A Prospective Cohort Study

Obstetrical & Gynecological Survey (2023)

Tanja Schlaikjær Hartwig Louise Ambye Jennifer R. Gruhn Jesper Friis Petersen Tine Wrønding

(Abstracted from Lancet 2023;401:762–771 Spontaneous pregnancy loss occurs in approximately 1 in 4 pregnancies; however, diagnostic workup is mostly restricted to women with recurrent pregnancy loss. The lack of workup on first pregnancy loss is likely a result of the high de novo fetal aneuploidy rate; however, this ignores the association of euploid pregnancy loss with an increased risk of future losses.

Early Pregnancy Loss

Cell-free fetal DNA

10.1097/ogx.0000000000001163

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Fresh tools, familiar findings: Machine learning in prediction of pregnancy loss

Fertility and Sterility (2024)

Jesper Friis Petersen Ellen Løkkegaard

10.1016/j.fertnstert.2024.05.136

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Cell-free fetal DNA for genetic evaluation in Copenhagen Pregnancy Loss Study (COPL): a prospective cohort study