To explore the changes of magnetic resonance imaging (MRI) and computed tomography (CT) after transplantation of VX2 carcinoma into lumbar vertebrae of rabbits under CT guidance and examine its relationship with the onset of paralysis.A total of 52 rabbits were randomly divided into 4 groups. Under CT guidance, pieces of VX2 carcinoma were transplanted into the first or second lumbar vertebra in Groups A, B and C (n = 14 each) while sham operation was performed in Group D (n = 10). The anticipated endpoints of group A was natural death or Day 50 post-operation, group B Day 3 after onset of paralysis, group C Day 14 post-transplantation and group D natural death or Day 50 post-operation. CT and MR scans were performed at an interval of 7 days and hind limb functions monitored daily post-operation until endpoints. Pathohistological examinations of vertebrae were performed at endpoints.All lumbar vertebrae were successfully transplanted under CT guidance. Thirty-two rabbits with spinal tumor and 9 surviving rabbits in the control group were monitored until endpoints. Abnormal signals on target vertebrae appeared on MRI in all 41 rabbits at Day 7 post-operation while positive CT findings were absent. No abnormal MRI/CT findings were found in 9 control rabbits from Day 14 post-operation to the end of study. Significant differences (P < 0.001) existed between the rates of tumor visualization with 65.6% (21/32) on MR and 3.1% (1/32) on CT at Day 14, 100% (21/21) on MR and 42.9% (9/21) on CT at Day 21. The rates of tumor visualization were 100% on both MR and CT from Day 28 to endpoints. The average survival time of Group A was significantly shorter than Group D (40 ± 4 vs 50 days, P < 0.01). The onset time of paralysis time in Group A (22 ± 5 days) had no significant difference with Group B (22 ± 5 days) (P = 0.952).A rabbit model of spinal metastasis is established with high rates of success and reproducibility. Vertebral tumor may be located earlier on MR than CT after transplantation of VX2 carcinoma. The examinations of MRI and CT after Day 7 post-operation are controversial. The survival time of rabbits with paralysis caused by spinal tumor is significantly shortened.
To study the natural history of dry type of age-related macular degeneration (AMD) and search for a sensitive method for detecting the development of the disease, the fundus fluorescein angiography, visual acuity, electroretinogram and FM 100-hue test were used to examine 75 eyes, 147 eyes, 73 eyes, and 94 eyes respectively. These examinations were taken at least twice during the follow-up periods. The average age was 63.2 years (50-80 years). The average follow-up was 29.8 months with a range of 3-74 months. It was shown tht there were not any statistically significant difference in the macular lesions and electroretinogram between the initial examinations and after follow-up (P > 0.05). 91.14% of the eyes maintained good visual acuity during the follow-up. Subretinal neovascularization developed only in one of the eyes. The total error score of FM 100-hue test had a statistically significant difference between the initial test and the test taken two years afterwards (P < 0.01). It was suggested that most of the dry type of AMD had a favorable prognosis and that color visual test was a sensitive method for monitoring the development of dry type of AMD.
Objective To explore the effect of family cohesion and adaptability on quality of life of patients with colostomy.Methods Totaled of 80 patients with rectal cancer colostomy were investigated with FACES Ⅱ - CV and were divided into high scores group and low scores group according to the scores of family cohesion and adaptability.The quality of life of patients were evaluated and compared between two groups with GQOLI -74.Results The scores of the quality of life in high scores group were higher than those in low scores group,the difference was significant.The patient's family cohesion and adaptability had a positive correlation with their physical function,psychological function,social function and quality of life.Conclusions The feeling of family cohesion should be paid attention to,the patients and their families should be treated with psychosocial interventions to improve quality of life of patients.
Key words:
Family cohesion; Adaptability; Rectal cancer; Colostomy; Quality of life
Objective To make the nursing records scientific,standard and succinet,seve the dascriping time and raise the performance rate of nursing process.Methods To redasigu a new bind of form which was fit for form'nursing records of neurosurgery.And compare it with the summary of single-care record groups.Results The mean time used in writing nursing records was decreased from 10.85 minutes per nurse per nursing record to 2.99 minutes.Moreover,The form of nursing record groups was improved in the form the entire fineness,record timeliness and the nursing measure correct and the arriving rate than the summary of single-care record groups.(P＜0.001).Conclusions The form'nursing records in neumsurgery form conforms to the request of form designing.And it's simple to use.Soit savas the time in writing nursing records.Also,it puts the nursing intervention into effect.Then the patients can get holistic care..
Key words:
Form-write; Form-type; Deparment of Nerve Surgery
The success of bone implants in the presence of osteoporosis is limited by lack of osseointegration between the implant and the natural bone. This study applied an electrochemical process to deposit simvastatin-nanohydroxyapatite (HA) coatings on porous implant surfaces and investigated the effects of these simvastatin-HA coatings on implant surfaces in an animal model of osteoporosis. In this study, simvastatin-HA coated implants were inserted into the tibia of osteoporotic rats. After 2, 4, and 12 weeks, tissue was retrieved for histomorphometric evaluation. The results indicated that the simvastatin-HA coatings increased bone-implant contact and new bone formation around implant surfaces. In conclusion, implants loaded with simvastatin by an electrochemical process improved implant osseointegration in osteoporotic rats. Furthermore, the increased concentration of simvastatin could affect the osseointegration, but the dose-effects also need further investigation.
perilobular pattern was observed 12 Peribronchial thickening was present in 8 patients (35%).There were 5 patients with traction bronchiectasis (22%), and no patients had honeycombing.Among the two patients who died, both of them had bilateral lung lesions and noted pleural effusion.In addition, they had traction bronchiectasis. Conclusion:In lung injuries caused by amiodarone, the patient presents with various CT findings.The perilobular pattern, peribronchial thickening, crazy-paving pattern, and mosaic pattern suggest the possibility of lung injury due to amiodarone.
Objective To discuss the effect of human-centered nursing technical operation training.Methods All of the the nursing staffs in the hospital were trained using user-friendly nursing technical operation training program,and the evaluation of the work of nursing staffs was conducted before,and after the training,and the effect of training was explored by a comparison of the nursing operation.Results After the training,the operation performance of nursing staffs is better than that before the training obviously.There was a statistically significant difference(P ＜ 0.01). Patients are more satisfactory with the nursing staffs' operation than before obviously.There was a statistically significant difference(P ＜0.05).Conclusions User-friendly nursing technical operation training is benificial to improving the nursing staffs' skills and enhancing the harmony,of relations between nursers and patients.
Key words:
User-friendly; Nursing skill operation; Training
Objective To evaluate the clinical efficacy of percutaneous vertebroplasty (PVP) in patients with symptomatic vertebral hemangiomas and determine whether prior intraosseous venography decreases extravertebral leakage of PMMA and improves clinical outcomes in these procedures.Methods Retrospective review was conducted on 45 consecutive patients with 53 symptomatic vertebral hemangiomas associated with chronic pain (all cases) or paralysis caused by spinal cord compression (1 case) or vertebral compression fractures (3 cases) treated with PVP at our institution to define two populations.Group A consisted of 27 vertebral hemangiomas in 23 patients who underwent intraosseous venography before injection polymethylmethacrylate (PMMA).Group B consisted of 26 vertebrae in 22 patients who underwent injection PMMA without prior venography.CT was done 1 to 3 days after PVP to observe PMMA distribution in vertebrae and whether leakage.Clinical outcomes,included pain relief,leakage of PMMA,volume of PMMA injected,expense and X-ray exposure times in each vertebral body,were compared in the two groups by using x2 or t test.Results No significant difference was seen between the groups with respect to age,sex,the number of treated vertebrae,or preprocedural degrees of pain.The successful rate of technique of PVP was 100%.The mean volume of PMMA injected in each vertebra was 3.96 ml.CR,PR and NR was obtained respectively 84.5%,13.3% and 2.2% during 6 months to 5 years of follow-up expect one case had unrelieved pain in group A.At 6 months after PVP,22 cases (95.7%) in group A and 22 cases (100%) in group B achieved adequate pain relief (P = 0.323).6 vertebrae (6/27) in group A and 2 vertebrae (2/26) in group B with asymptomatic leakage of PMMA were demonstrated by CT (P =0.140).The mean volume of PMMA injected in each vertebra was 3.70 ml in group A and 4.23 ml in group B (P =0.157).The mean expense of each vertebra was (￥)7.24 × 103 in group A and (￥)5.84 × 103 in group B (P=0.000),the mean decreases were (￥)1.4 × 103 in group B than group A.The mean X-ray exposure times on each vertebral body was 13.28 minutes in group A and 8.78 minutes in group B (P =0.000),the mean decreases were 4.5 minutes in group B than group A.Conclusions PVP is an effective and safe procedure for treating symptomatic vertebral hemangiomas.Prior intraosseous venography does not significantly improve the effectiveness or safety of PVP for vertebral hemangiomas performed by qualified,experienced operators,on the other hand,it increases the expense and X-ray exposure times of PVP.
Key words:
Vertebroplasty; Polymethylmethacrylate; Vertebral hemangiomas; Intraosseous venography
Percutaneous vertebroplasty (PVP) is widely used for the treatment of painful vertebral compression fractures (VCFs). However, new VCFs occur frequently after PVP.We aim to establish an objective risk score system to assess the possibility of new vertebral fractures in patients with VCFs undergoing PVP.This study was a retrospective study, and it was approved by the Institutional Review Board of our 2 institutions.This study consists of patients from 2 large academic centers.Patients with VCFs who underwent their first PVP and met the inclusion criteria between January 2007 and December 2013 at Hospital A (training cohort) and Hospital B (validation cohort) were included. In the training cohort, the independent risk factors for new VCFs after PVP were identified by multivariate stepwise backward Cox regression analysis from the risk factors selected by univariate analysis and Harrell's C-statistics and used to develop the score system (assessment for new VCFs after PVP [ANVCFV]) to predict the probability of new VCFs.In total, 397 patients (training cohort: n = 241; validation cohort: n = 156) were included in this study. In the training cohort, the ANVCFV score was developed based on 5 independent risk factors for the new VCFs after PVP, including lower computed tomography (CT) values, pre-existing old VCFs, intradiscal cement leakage, more than one vertebra treated, and superior or inferior marginal cement distribution in the vertebra. The patients were divided into 2 groups by the ANVCFV score of -1.5 to 8.5 vs. > 8.5 points in the probability of new VCFs (median fracture-free time: 1846 vs. 732 days; P < 0.001) in the training cohort. The accuracy of this score system was 77.4% for the training cohort and 85.3% for the validation cohort.The main limitations of this study are that it is a retrospective study and that there is a significant difference of the treated vertebrae of PVP per session between the 2 cohorts.Patients who underwent their first PVP with an ANVCFV score > 8.5 points may exhibit an increased chance of suffering from new VCFs.
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