Roberto Iemitsu Tatakihara

Universidade Estadual de Londrina

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Marla Karine Amarante

Universidade Estadual de Londrina

T. Fujita

Universidade Estadual de Londrina

Luiz Antônio Custódio

Universidade Estadual de Londrina

Karina de Almeida Gualtieri

Centro Universitário Filadélfia

V Castro

University of Trás-os-Montes and Alto Douro

Mateus Nóbrega Aoki

Fundação Oswaldo Cruz

Leandra Fiori Lopes

Universidade Estadual de Londrina

Alexandre Yukio Saito

Japan Women's University

Jair Tonon

Universidade Estadual de Londrina

Maria Angélica Ehara Watanabe

Universidade Estadual de Londrina

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Universidade Estadual de Londrina

Centro Universitário Filadélfia

Entomological Society of Brazil

Universidade de São Paulo

Fundação Araucária

Centro de Investigaciones Biológicas Margarita Salas

Laureate Education

Secretaria Municipal de Cultura

Hospital de Clínicas

Centro de Estudos em Psicologia da Saúde

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Análise dos efeitos da epigalocatequina-3-galato (EGCG) de Camellia sinensis (chá verde) em modelo de hepatotoxicidade química experimental induzida pela Dietilnitrosamina (DEN)

Semina Ciências Biológicas e da Saúde (2013)

V Castro Karina de Almeida Gualtieri Alexandre Yukio Saito Roberto Iemitsu Tatakihara Julie Massayo Maeda Oda

Diethylnitrosamine (DEN), a known hepatotoxic and carcinogenic substance, was used in the induction of centrilobular hepatic necrosis in isogenic Lewis rats divided into 5 groups with 5 animals. The aim of this study was to evaluate the chemopreventive effect of epigallocatechin-3-gallate (EGCG) from Camellia sinensis (green tea) in the treatment of cellular hepatotoxicity induced by DEN. It was measured the serum concentration of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of the different experimental groups. In the biochemistry assay for AST and ALT, there was significant difference between median values of control group (163±70.32) compared to DEN group (1631±1039.44), suggesting that DEN influences on hepatic function. However, there was no significant difference between DEN group to that treated with epigallocatechin. Lactate dehydrogenase (LDH) is considered a common biochemical marker for evaluation of tumor progression, and regarding LDH, the samples presented no significant differences between the DEN group (1385.5±43.13) and DEN + EGCG 150mg or DEN + EGCG 200mg (1537.5± 1010.45). In this work it was demonstrated that epigallocatechin concentrations of 150 and 200 mg/kg did not induce liver alterations and though was not verified any chemoprotective effect by EGCG in animals initially treated with DEN for 24 hours. Moreover, new experiments with different concentrations of EGCG are needed to verify its possible chemoprotector effect.

10.5433/1679-0367.2013v34n2p215

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Determinação da lactate desidrogenase (LDH) e do transcrito Bcr-Abl em pacientes com leucemia mielóide crônica

Acta Scientiarum Health Sciences (2010)

Roberto Iemitsu Tatakihara Marla Karine Amarante Mateus Nóbrega Aoki T. Fujita Maria Angélica Ehara Watanabe

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