No AccessJournal of UrologyInvestigative Urology1 Apr 1997Genetic Variations in Human Benign Prostatic Hyperplasia Detected by Restriction Landmark Genomic Scanning Noboru Konishi, Yoshio Hiasa, Hirofumi Matsuda, Mitsutoshi Nakamura, and Yoshiteru Kitahori Noboru KonishiNoboru Konishi More articles by this author , Yoshio HiasaYoshio Hiasa More articles by this author , Hirofumi MatsudaHirofumi Matsuda More articles by this author , Mitsutoshi NakamuraMitsutoshi Nakamura More articles by this author , and Yoshiteru KitahoriYoshiteru Kitahori More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65031-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Alterations in the genomic DNAs of benign prostatic hyperplasias were examined using restriction landmark genomic scanning. This methodology allows the visual comparison of a large number of loci as spots within a gel that has been electrophoresed in 2 dimensions. Within each of the 16 hyperplasias examined, we found 2 to 10 spots with altered intensities, as compared to equivalent spots from normal prostate, but could detect few common spot profiles for any hyperplasia samples. These data conflict with data from previous studies and suggest that there may be no consistent genetic changes in the pathogenesis of some forms of human benign prostatic hyperplasia. References 1 : DNA alterations in prostatic adenocarcinoma and benign prostatic hyperplasia: detection by DNA fingerprint analyses. Mutat. Res.1990; 237: 37. Google Scholar 2 : Hypomethylation of DNA in pathological conditions of the human prostate. Cancer Res.1987; 47: 5274. Google Scholar 3 : The int-2 gene product acts as an epithelial growth factor in transgenic mice. EMBO J.1990; 9: 907. 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Google Scholar From the Second Department of Pathology, Nara Medical University, Kashihara, Nara, Japan© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byLEE K and PEEHL D (2018) MOLECULAR AND CELLULAR PATHOGENESIS OF BENIGN PROSTATIC HYPERPLASIAJournal of Urology, VOL. 172, NO. 5, (1784-1791), Online publication date: 1-Nov-2004.DE MARZO A, NELSON W, MEEKER A and COFFEY D (2018) STEM CELL FEATURES OF BENIGN AND MALIGNANT PROSTATE EPITHELIAL CELLSJournal of Urology, VOL. 160, NO. 6 Part 2, (2381-2392), Online publication date: 1-Dec-1998. Volume 157Issue 4April 1997Page: 1499-1503 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Noboru Konishi More articles by this author Yoshio Hiasa More articles by this author Hirofumi Matsuda More articles by this author Mitsutoshi Nakamura More articles by this author Yoshiteru Kitahori More articles by this author Expand All Advertisement PDF downloadLoading ...
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