Saad Bakrim

Université Ibn Zohr

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Abdelhakim Bouyahya

Mohammed V University

Asaad Khalid

Jazan University

Youssef Elouafy

Mohammed V University

Tarik Aanniz

Mohammed V University

Ashraf N. Abdalla

Umm al-Qura University

Long Chiau Ming

Sunway University

Jihane Touhtouh

Sidi Mohamed Ben Abdellah University

Roaya S. Alqurashi

Umm al-Qura University

Abdelaali Balahbib

Instituts Supérieurs des Professions Infirmières et Techniques de Santé

Ikrame Zeouk

Sidi Mohamed Ben Abdellah University

Cooperative Institutions

Mohammed V University

Sidi Mohamed Ben Abdellah University

Sunway University

Abdelmalek Essaâdi University

Airlangga University

Instituts Supérieurs des Professions Infirmières et Techniques de Santé

Monash University Malaysia

Universiti Brunei Darussalam

Jazan University

National Centre for Research

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Exploring the chemistry, biological effects, and mechanism insights of natural coumaroyltyramine: First report

Fitoterapia (2024)

Saad Bakrim Youssef Elouafy Jihane Touhtouh Tarik Aanniz Kawtar El Kadri

Phenylpropanoid

Nutraceutical

Cannabis sativa

10.1016/j.fitote.2024.106182

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DNA Methylation: Its Role and Interaction with Epigenetic Modifications in Cancer

Progress In Microbes & Molecular Biology (2025)

Nasreddine El Omari Saad Bakrim Mohamed Bakha Abdelaali Balahbib Abdelhakim Bouyahya

DNA methylation is an epigenetic mark involving the addition of a methyl group to DNA, particularly at cytosine residues. This methylation plays an important role in regulating gene expression through direct gene repression or through the control of other epigenetic modifications such as histone modification or chromatin remodeling. DNA methylation is catalyzed by de novo and maintenance DNMT methyltransferase type enzymes and requires the transfer of a methyl group to cytosine to transform it into 5-methyl-cytosine. Currently, several investigations have highlighted the involvement of aberrant DNA methylation with certain tumors. Indeed, the methylation of antioncogenes and/or the demethylation of oncogenes are the major alterations that are strongly linked to human cancers. DNMTs play a central role in the epigenetic regulation of the human genome, both in normal and pathological processes. Recent discoveries on the differentiated roles of DNMTs in DNA methylation, and their implication in various cancers, open the way to new therapeutic approaches targeting these enzymes to treat epigenetic diseases. It is essential to continue exploring the roles of DNMTs to better understand their implication in tumorigenesis mechanisms and to develop more effective treatment strategies.

Cancer Epigenetics

10.36877/pmmb.a0000458

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Unveiling the Biological Effects and Pharmacological Properties of Sorbifolin: a Comprehensive Review

Chemistry & Biodiversity (2024)

Omar Belmehdi Ibrahim Mssillou Asaad Khalid Ashraf N. Abdalla Manal Almalki

Abstract Bioactive phytochemicals act as important factors with preventive and therapeutic potential in the pathogenesis of several disorders, often related to oxidative stress. Many dietary plant secondary metabolites could lower these conditions. Sorbifolin is one of these metabolites. This work is the first review of sorbifolin, a flavone detected in various plant matrices as a major compound. The present study discussed the natural sources, extraction, purification, quantification, and assessment of the biological activities of sorbifolin. Several databases including Google Scholar, Web of Sciences, and Science‐Direct were consulted for relevant English articles related to sorbifolin, the phytochemical profiles of several medicinal plants containing this compound, and its biological activities, such as antioxidant, anticancer, antimicrobial, anti‐inflammatory, and antidiabetic. The positive in vitro and in silico outcomes reported in the literature should be followed by additional in vivo and clinical investigations to further research the mechanisms of action, pharmacokinetic/pharmacodynamic activities, toxicological effects, pharmacological properties, and therapeutic potential of sorbifolin.

10.1002/cbdv.202401463

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Initial report on the multiple biological and pharmacological properties of hispolon: Exploring stochastic mechanisms

Biomedicine & Pharmacotherapy (2024)

Tarik Aanniz Ikrame Zeouk Youssef Elouafy Jihane Touhtouh Rym Hassani

Phellinus linteus

Inonotus obliquus

10.1016/j.biopha.2024.117072

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