Ya Wu

Shanghai University of Traditional Chinese Medicine

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Jing‐Chao Tao

Shanghai Jiao Tong University

Zhenlei Song

Sichuan University

Lu Gao

Sichuan University

Yin‐Xia Sun

Lanzhou Jiaotong University

Shao Dong Pan

Liaocheng People's Hospital

Cong-Jun Liu

Philip G. de Groot

University Medical Center Utrecht

Hongjia Zhang

Shanghai Jiao Tong University

Jin‐Shuai Lan

Shanghai University of Traditional Chinese Medicine

Zhishan Su

Sichuan University

Cooperative Institutions

Liaocheng People's Hospital

Sichuan University

Chinese Academy of Sciences

Lanzhou Jiaotong University

Shanghai University of Traditional Chinese Medicine

Shandong University

First Affiliated Hospital of Henan University

Taishan Medical University

Shanghai Jiao Tong University

Sun Yat-sen University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

PCR and GM-ELISA diagnosis of aspergillosis for SARS patients received corticosteroids treatment

Ya Wu Infl

Source

Cite

Citations (0)

Nonlinear Stability Analysis of Qijiadu Long-Span Deck-Type CFST Arch Bridge

Advanced materials research (2010)

Liang Xu Ya Wu

With the application of the composition material-concrete-filled-steel-tube (CFST) in civil engineering, the crossing ability of arch bridge gets advanced development. Therefore, it is of interesting to study the stability of such long-span arch bridges, especially which have small width, for the bridge’s safety under long term operation. The present study focuses on studies the transverse stability of long-span arch bridges with small width. To this purpose, a deck type CFST arch-bridge in Gansu Province is adopted as an example. The arch bridge has a span of 180 m, and its width-span ratio is 1/25.7. The finite element method with a special beam element is employed to analyze the stability. The analyses are carried out for the transverse stability of the bridge during construction and under service, respectively. Furthermore, the influence of the spandrel structure and deck elastic restraints to the stability is investigated taking account of geometrical and material nonlinearity.

Beam bridge

Arch bridge

Bridge (graph theory)

10.4028/www.scientific.net/amr.163-167.1685

Cite

Citations (0)

Using fibrin composite interfacesin vitroexperimental model to study of the ultra-structures of the fibrin composite generated by the plasma knife for surgery and electrocautery

Composite Interfaces (2012)

Bin Zhang Shao Dong Pan Ying Yuan Ke Yi Li Li Shen

Stop the bleeding is a complex biological process named as the coagulation of human blood. The formation of the fibrin composite network is a very important step. The aim of the present study is set a fibrin composite interface experimental model in vitro to mimic the formation of fibrin composite network and compare the ultra-structures of the fibrin composite interfaces generated by using a plasma knife for surgery and electrocautery. A fibrin composite interface experimental model in vitro was set to mimic the formation of fibrin composite network and compare the ultra-structures of the fibrin composite interfaces generated by using a plasma knife for surgery to electrocautery. As control, the fibrin composite interfaces were generated by adding thrombin to plasma. The characterization of the ultra-structures of the fibrin composite interfaces generated by catalyzed with thrombin is a fine network. In both ultra-structures of the fibrin composite interfaces generated by the plasma knife for surgery and electrocautery, the individual fibers could not be clearly identified. Thickened and matted fibrin is indicative of the morphology seen. It is shown that there is a different model in fibrin composite interface formation. However, the ultra-structures of the fibrin composite interfaces generated by electrocautery were seen much coarse and loosely packed than the fibrin composite interfaces generated by a plasma knife for surgery. It may be due to the lower work temperature from the plasma knife for surgery methods. However, this is only a notable characterization of the ultra-structures of the fibrin composite interfaces generated by a plasma knife. To further study the better wound healing profile, which seen in the using of the plasma knife, the work, using platelet rich plasma or whole blood clots will be performed.

10.1080/09276440.2012.696953

Cite

Citations (0)

CCDC 1965458: Experimental Crystal Structure Determination

The Cambridge Structural Database (2020)

Jian Chang Shuzhen Zhang Ya Wu Hongjia Zhang Yin‐Xia Sun

10.5517/ccdc.csd.cc23z6w6

Cite

Citations (0)

Stress Analysis of Steel Deck Pavement of Box Girder Bridge under Vehicle Wheel Loads

Advanced materials research (2010)

Liang Xu Ya Wu

This paper deals with the mechanical property of a new designed bridge pavement of box girder bridges. Our concerning is the stress change at the interface between the steel deck and the pavement due to the vehicle wheel loads, which can be considered as a kind of concentration force to the pavement. The finite element method is utilized to analyze the present problem. Several simulations are carried out by taking account of different positions of the vehicle wheels in order to simulate the interface stress change under real conditions. The present results can be a helpful reference for steel-deck pavement design.

Bridge deck

Bridge (graph theory)

Box girder

10.4028/www.scientific.net/amr.163-167.812

Cite

Citations (0)

Lentivirus-based RNA Silencing of Nemo-like Kinase (NLK) Inhibits the CAL 27 Human Adenosquamos Carcinoma Cells Proliferation and Blocks G0/G1 Phase to S Phase

International Journal of Medical Sciences (2013)

Bin Zhang Ke Yi Li Hai Ying Chen Shao Dong Pan Shuang Feng Chen

Background:The Nemo-like kinase (NLK) is a serine/threonine-protein kinase that involved in a number of signaling pathways regulating cell fate.Variation of NLK has been shown to be associated with the risk of cancer.However, the function of NLK in oral adenosquamous carcinoma cells line CAL-27 is unknown.Methods: In this study, we evaluated the function of NLK in CAL-27 cells by using lentivirus-mediated RNA silence.The targeted gene expression, cell proliferation and cell cycle are investigated by RT-PCR, western-blot, MTT method, colony forming assay and flow cytometry analysis respectively.Results: After NLK silencing, the number of colonies was significantly reduced (54±5 colonies/well compared with 262±18 colonies/well in non-infected or 226±4 colonies/well in negative control group (sequence not related to NLK sequence with mismatched bases).Using crystal violet staining, we also found that the cell number per colony was dramatically reduced.The RNA silencing of NLK blocks the G0/G1 phase to S phase progression during the cell cycle.Conclusions: These results suggest that NLK silencing by lentivirus-mediated RNA interference would be a potential therapeutic method to control oral squamous carcinoma growth.

10.7150/ijms.6607

Cite

Citations (7)

Experimental Study on the Mechanical Behavior of Truncated Hip Structure

Applied Mechanics and Materials (2014)

Yan Yang Hu Yong Li Ya Wu

Based on the characteristics of organic glass, organic glass plate is adopted to establish the test model, and through the static stress and strain values of stress and strain test model, the theory is simulated by using ANSYS finite element software, at the same time, through the theoretical analysis and the method of combining the structure model test, the truncated hip structure, the mechanical properties of special section.

Stress–strain curve

Section (typography)

Strain (injury)

10.4028/www.scientific.net/amm.578-579.488

Cite

Citations (2)

Platelet binding and phagocytosis by macrophages

Transfusion (2006)

Bahram Alamdary Badlou Ya Wu W. M. Smid Jan‐Willem N. Akkerman

BACKGROUND: Earlier it was reported that metabolic arrest followed by incubation at 4°C reduces the platelet (PLT) storage defect. Here it is reported that this treatment also reduces binding and phagocytosis by macrophages. STUDY DESIGN AND METHODS: Phagocytosis of mepacrine‐labeled PLTs by macrophages changes the latter into bright fluorescent particles easily detected by fluorescence‐activated cell sorting. RESULTS: In combination with conventional binding analysis it was found that binding to phorbol 12‐myristate 13‐acetate–matured THP‐1 cells is primarily regulated by PLT P‐selectin expression and phagocytosis by combined phosphatidylserine (PS) exposure and glycoprotein (GP) Ibα clustering. It was found that trapping of PLT Ca 2+ and raising cAMP reduces phagocytosis by lowering PS exposure. Chilling of PLTs leads to an increase in binding and PS‐ and GPIbα‐mediated phagocytosis. Prior depletion of PLT energy stores prevents this increase by preserving low Ca 2+ concentration, PS exposure, and PS‐mediated phagocytosis. CONCLUSION: These data characterize the individual factors that control PLT binding and phagocytosis and might help to define conditions that improve the survival of stored PLTs after transfusion.

10.1111/j.1537-2995.2006.00913.x

Cite

Citations (56)

Homotypic cell membrane-camouflaged biomimetic PLGA nanoparticle loading triptolide for the treatment of hepatocellular carcinoma

Drug Delivery (2024)

Zhe Li Jin‐Shuai Lan Ya Wu Yue Ding Tong Zhang

Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-associated death worldwide. Beside early detection, early diagnosis, and early surgery, it is urgent to try new strategies for the treatment of HCC. Triptolide (TPL) has been employed to treat HCC. However, its clinical applications were restricted by the narrow therapeutic window, severe toxicity, and poor water-solubility. In this study, we developed cancer cell membrane-camouflaged biomimetic PLGA nanoparticles loading TPL (TPL@mPLGA) with the homologous targeting property for the treatment of HCC. The TPL@mPLGA was successfully prepared with particle size of 195.5 ± 7.5 nm and zeta potential at −21.5 ± 0.2 mV with good stability. The drug loading (DL) of TPL@mPLGA was 2.94%. After Huh-7 cell membrane coating, the natural Huh-7 cell membrane proteins were found to be retained on TPL@mPLGA, thus endowing the TPL@mPLGA with enhanced accumulation at tumor site, and better anti-tumor activity in vitro and in vivo when compared with TPL or TPL@PLGA. The TPL@mPLGA showed enhanced anti-tumor effects and reduced toxicity of TPL, which could be adopted for the treatment of HCC.

Triptolide

PLGA

Hepatic carcinoma

10.1080/10717544.2024.2354687

Cite

Citations (1)

Suppressing platelet microparticle formation by antibodies against platelet glycoprotein GPIb

Thrombosis and Haemostasis (2007)

Xiao Min Zhao Philip de Groot Ya Wu

Suppressing platelet microparticle formation by antibodies against platelet glycoprotein GPIb -

Microparticle

Glycoprotein Ib

10.1160/th06-12-0738

Cite

Citations (1)