Karina Helen Martins

Universidade de São Paulo

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Jorge Esquiche León

Universidade de São Paulo

Vitória Pereira Alves

Universidade Federal dos Vales do Jequitinhonha e Mucuri

Ana Cláudia Oliveira Teles

Universidade Federal dos Vales do Jequitinhonha e Mucuri

Gabriela Fonseca Rocha

Universidade Federal dos Vales do Jequitinhonha e Mucuri

Ana Terezinha Marques Mesquita

Universidade Federal dos Vales do Jequitinhonha e Mucuri

Débora Fernandes Mendes Silveira

Centro Universitário de Araraquara

Andiara De Rossi

Universidade de São Paulo

Gabriel Dias de Araújo

Universidade Federal dos Vales do Jequitinhonha e Mucuri

Evânio Vilela Silva

Universidade Estadual Paulista (Unesp)

Marcelo Dias Moreira de Assis Costa

Universidade Federal de Uberlândia

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Universidade Federal dos Vales do Jequitinhonha e Mucuri

Universidade de São Paulo

Universidade Estadual Paulista (Unesp)

Universidade Estadual de Campinas (UNICAMP)

Centro Universitário de Araraquara

Universidade Federal de Minas Gerais

Universidade de Ribeirão Preto

Universidade Federal de Uberlândia

Fundação Faculdade de Odontologia

Universidade Estadual de Montes Claros

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Stromal Myofibroblasts in Correlation With Inflammation and Impacted Tooth in Odontogenic Cysts: An Immunohistochemical Comparative Study

Research Square (Research Square) (2023)

Karina Helen Martins CAMILA DE OLIVEIRA BARBEIRO Roberto Henrique Barbeiro Ana Lia Anbinder R. Guardia

Abstract Aim Stromal myofibroblasts may act favoring growth and progression of odontogenic lesions, notably odontogenic keratocyst (OKC). While little explored the associated inflammation, it has been shown that OKC associated with an impacted tooth has a tendency toward rapid growth. Whether this finding is associated with the differential expression of myofibroblast immunomarkers, is unknown. Materials and methods Thirteen cases of each, pericoronal follicle (PF), inflamed dentigerous cyst (iDC), noninflamed DC (nDC), OKC associated with (OKC-A) or not associated (OKC-N) with impacted tooth, were evaluated through vimentin, α-SMA, calponin and h-caldesmon immunomarkers The data obtained were analyzed using the Shapiro-Wilk, Kruskal-Wallis and Dwass-Steel-Critchlow-Fligner Multiple Comparisons tests, with p < 0.05 being considered statistically significant. Results All cases were vimentin positive, with few cases exhibiting mild expression. All PFs were α-SMA negative. OKCs showed significant higher expression of α-SMA than DCs (p < 0.05). With similar expression between DC groups, the α-SMA expression was higher in OKC-A than OKC-N (p = 0.882). Also, the mean age of OKC-A was significantly lower than OKC-N patients. Only 4 cases (1 iDC, 3 OKC-N) showed mild expression of calponin. All cases were h-caldesmon negative. Conclusions Our results suggest lack of myofibroblastic differentiation in PFs. Inflammation does not seem to influence the myofibroblast population in DCs. Although not significant, a higher expression of α-SMA can explain the clinicopathological features of OKC-A patients. Calponin seems not to be a reliable marker for myofibroblasts in these cases. Clinical relevance Lack of myofibroblastic differentiation seems to be consistent with the nature and function of PF. OKC (still, OKC-A than OKC-N) presents higher α-SMA expression than DC, which can help to explain its distinctive growth potentials.

Keratocyst

Myofibroblast

Calponin

Caldesmon

10.21203/rs.3.rs-3179661/v1

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Miofibroblastos estromais em correlação com inflamação e dente impactado em cistos odontogênicos: um estudo imunohistoquímico comparativo

Karina Helen Martins

Stromal myofibroblasts may act favoring growth and progression of odontogenic lesions, notably odontogenic keratocyst (OKC).While little explored the associated inflammation, it has been shown that OKC associated with an impacted tooth has a tendency toward rapid growth.Whether this finding is associated with the differential expression of myofibroblast immunomarkers, is unknown.Thirteen cases of each, pericoronal follicle (PF), inflamed dentigerous cyst (iDC), noninflamed DC (nDC), OKC associated with (OKC-A) or not associated (OKC-N) with impacted tooth, were evaluated through vimentin, α-SMA, calponin and h-caldesmon immunomarkers.The data obtained were analyzed using the Shapiro-Wilk, Kruskal-Wallis and Dwass-Steel-Critchlow-Fligner Multiple Comparisons tests, with p<0.05 being considered statistically significant.All cases were vimentin positive, with few cases exhibiting mild expression.All PFs were α-SMA negative.OKCs showed significant higher expression of α-SMA than DCs (p<0.05).With similar expression between DC groups, the α-SMA expression was higher in OKC-A than OKC-N (p=0.882).Also, the mean age of OKC-A was significantly lower than OKC-N patients.Only 4 cases (1 iDC, 3 OKC-N) showed mild expression of calponin.All cases were h-caldesmon negative.Our results suggest lack of myofibroblastic differentiation in PFs.Inflammation does not seem to influence the myofibroblast population in DCs.Although not significant, a higher expression of α-SMA can explain the clinicopathological features of OKC-A patients.Calponin seems not to be a reliable marker for myofibroblasts in these cases.

Keratocyst

Myofibroblast

Calponin

10.11606/d.58.2023.tde-25102023-162822

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Imunoexpressão de CD209 e Fator XIIIA: uma Revisão Narrativa de Literatura

Even3 Publicações eBooks (2024)

Gabriela Fonseca Rocha Ana Cláudia Oliveira Teles Vitória Pereira Alves Karina Helen Martins Luana Stefanie Silvino Gonçalves

O capítulo explora o papel dos imunomarcadores CD209 e Fator XIIIa em contextos tumorais. O sistema imunológico, crucial na defesa contra patógenos e câncer, destaca-se pela imunidade inata e adaptativa. As células dendríticas (CDs) e macrófagos, primeiras linhas de vigilância, são consideradas alvos promissores na imunoterapia do câncer. A técnica de imuno-histoquímica (IHQ) é essencial na pesquisa da patologia oral, fornecendo informações diagnósticas e prognósticas. Neste contexto, a revisão narrativa da literatura aborda a ambivalência das CDs no microambiente tumoral e destaca estudos sobre CD209 e Fator XIIIa em diversas condições patológicas. A escassez de estudos enfatiza a necessidade de mais pesquisas na carcinogênese oral. A metodologia foi baseada na busca por estudos publicados, critérios de inclusão e exclusão, resultando na seleção de 9 artigos para revisão. Destacou-se a complexidade do papel das CDs e Fator XIIIa no ambiente tumoral e dermatológico, oferecendo insights para futuras pesquisas e tratamentos inovadores. O capítulo ressalta a importância desses imunomarcadores na tumorigênese, oferecendo percepções valiosas para o diagnóstico, tratamento, prognóstico e predição em diversos tipos de câncer.

10.29327/5341296.1-7

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Intraoral Lymphomatoid Papulosis Type D Showing Scarce/Absent CD30 Expression in A Pediatric Patient: Case Report and Literature Review

Head and Neck Pathology (2025)

Mariana Paravani Palaçon Marcelo Borges Marques Débora Fernandes Mendes Silveira Karina Helen Martins Heitor Albergoni Silveira

Lymphomatoid papulosis

10.1007/s12105-024-01749-9

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Integração em saúde - a interdisciplinaridade no ambiente transdisciplinar

Even3 Publicações eBooks (2024)

Lia Dietrich Cristina Pereira Isolan Cíntia Tereza Pimenta de Araújo Adriano Almeida Rodrigues Ana Cláudia Oliveira Teles

Este livro digital é direcionado para a aprendizagem e atualização contínua que a área de Odontologia exige. Desta forma, anualmente será publicado sua edição no intuito de contribuir para a formação profissional dos acadêmicos e profissionais da área. Esta primeira edição conta com assuntos contemporâneos tratados com conceitos atuais, além de assuntos que são considerados mais recentes na área, voltados para a prática clínica, incluindo temas relacionados ao empreendedorismo. Esperamos que apreciem e que o conteúdo contribui para o enriquecimento intelectual de todos!

10.29327/5341296

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