A. Moruno Rodríguez

Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno

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F. López Herrero

Hospital Universitario Virgen del Rocío

Juan Ignacio Enghelmayer

University of Buenos Aires

A. Muñoz Morales

Hospital Universitario Virgen del Rocío

Macarena Díaz

Instituto de Investigación Biomédica de A Coruña

Cecilia Pisoni

Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno

A. Martínez Borrego

Hospital Universitario Virgen del Rocío

T. Rueda Rueda

Hospital Universitario Virgen del Rocío

M. Castilla Martino

Hospital Universitario Virgen del Rocío

Maria Simona Pino

Hospital de Clínicas "José de San Martín"

Ana María Putruele

Hospital de Clínicas "José de San Martín"

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Hospital Universitario Virgen del Rocío

University of Buenos Aires

Hospital de Clínicas "José de San Martín"

Institute for Medical Research

Center for Rheumatology

Gobierno de Aragón

Hospital Universitario de Torrejón

Brown University

Royal Prince Alfred Hospital

Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia

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Anti-Ro-52 antibodies in interstitial lung disease associated with autoimmune disorders

Juan Ignacio Enghelmayer A. Moruno Rodríguez Tamara Arias María José López Meiller Marina Garcia Carrasco

Background: Interstitial lung disease (ILD) is a frequent manifestation of connective tissue diseases (CTD). Some studies show a high prevalence of Anti-Ro52 in patients with ILD associated CTD and potentially related with poor prognosis. Objectives: To describe demographic, clinical, serological and radiological features, treatment and outcomes in a patient cohort. Methods: We conducted a longitudinal descriptive study incluiding patients from 2 centers in Argentina who exhibit ILD and Ro52. Results: 24 patients were included (95.8% female) with a mean age of 58 years. The average follow-up was 29.5 months. Most patients had chronic pulmonary symptoms.16 patients (66.6%) met the criteria for CTD, while 20.9% were unclassifiable and 12.5% were diagnosed with interstitial pneumonia with autoimmune features. Within the CTD group, half of the patients had idiopathic inflammatory myopathies while systemic sclerosis and overlap syndrome were equally present (18.75%). Most patients (95.8%) had positive antinuclear antibodies, and 62.5% had a positive total Anti Ro. Seven patients (29%) had an isolated Ro52-positive (negative for total Anti Ro); 29.1% had positive Rheumatoid factor and 15% had Anti la positive. Basal FVC showed mild restriction and DLCO was moderately reduced. Both values did not significantly change over time. Most patients had NSIP pattern on CT-scan (63.6%), and the most common treatment was corticosteroids (66.6%). One patient died (4.1%), 14 patients had hospital admissions (58.3%), and 2 required oxygen therapy (8.3%). Conclusions: Most patients with ILD-RO52 exhibited association with CTD. Ro52 antibodies did not correlate with the presence of total SSA-Ro antibodies.

Overlap syndrome

CTD

DLCO

Usual interstitial pneumonia

Rheumatoid factor

Scleroderma (fungus)

10.1183/13993003.congress-2023.pa1166

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Retinopatía Purtscher- like previa a fallo renal agudo

Archivos de la Sociedad Española de Oftalmología (2017)

Jorge Vicente M. Castilla Martino Macarena Díaz T. Rueda Rueda F.E. Molina Socola

10.1016/j.oftal.2017.06.005

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