Christine Roméro

Columbia University

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Jean‐Paul Ortonne

Inserm

ÉA

Édith Aberdam

Inserm

Catherine Larnier

Roche (France)

Guerrino Meneguzzi

Inserm

G Laurent

Inserm

José Chaboche

Université d'Orléans

Charles Exley

Columbia University

Ed Galloway

Columbia University

Meredith Martin

Durham University

Michael Temple

Columbia University

Cooperative Institutions

Columbia University

136

University of Pittsburgh

Inserm

Université Côte d'Azur

Centre National de la Recherche Scientifique

Université d'Orléans

Universidad de Murcia

University of Rochester

Université de Montréal

Université Laval

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Involvement of the melanogenic enzymes expression

Christine Roméro Édith Aberdam Catherine Larnier Jean‐Paul Ortonne

Retinoic acid (RA) is a hormone-like agent involved in the control of cell differentiation. The most characteristic feature of melanocyte differentiation, melanogenesis, is stimulated by UV radiations. Excessive chronic sun exposure results in irregular skin hypermelanosis that can be partially corrected by topical RA. The basic mechanisms underlying this effect of RA are unknown. To determine whether RA can directly modulate excessive melanin synthesis, we analyzed the in vitro effect of cis- and transRA on UVB-induced melanogenesis in S91 mouse melanoma cells and in normal human melanocytes (NHM). In both cells types, the two RA isoforms significantly decreased the UVB-stimulated melanogenesis in term of tyrosinase activity and melanin neosynthesis. To correlate changes in melanogenesis with the expression of melanogenic enzymes, we determined the neosynthesis rate of tyrosinase, tyrosinase-related protein-1 (TRP-1/gp 75) and tyrosinase-related protein-2 (TRP-2/DOPAchrome tautomerase). Here we show that UVB-induced melanogenesis in NHM is related to an increased synthesis of tyrosinase and TRP-1 and to a dramatic decrease of TRP2 expression. RA inhibition of UVB-induced melanogenesis acts at the post-transcriptional level leading to a decreased tyrosinase and TRP-1 synthesis. We also show that in NHM, inhibition of TRP-2 following UVBtreatment is significantly reversed by RA. This demonstrates a negative correlation between melanogenesis and TRP-2 expression. SUMMARY

Melanocyte

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Retinoic acid as modulator of UVB-induced melanocyte differentiation: Involvement of the melanogenic enzymes expression

Journal of Cell Science (1994)

Christine Roméro Édith Aberdam Catherine Larnier Jean‐Paul Ortonne

Retinoic acid (RA) is a hormone-like agent involved in the control of cell differentiation. The most characteristic feature of melanocyte differentiation, melanogenesis, is stimulated by UV radiations. Excessive chronic sun exposure results in irregular skin hypermelanosis that can be partially corrected by topical RA. The basic mechanisms underlying this effect of RA are unknown. To determine whether RA can directly modulate excessive melanin synthesis, we analyzed the in vitro effect of cis- and trans-RA on UVB-induced melanogenesis in S91 mouse melanoma cells and in normal human melanocytes (NHM). In both cells types, the two RA isoforms significantly decreased the UVB-stimulated melanogenesis in term of tyrosinase activity and melanin neosynthesis. To correlate changes in melanogenesis with the expression of melanogenic enzymes, we determined the neosynthesis rate of tyrosinase, tyrosinase-related protein-1 (TRP-1/gp 75) and tyrosinase-related protein-2 (TRP-2/DOPAchrome tautomerase). Here we show that UVB-induced melanogenesis in NHM is related to an increased synthesis of tyrosinase and TRP-1 and to a dramatic decrease of TRP-2 expression. RA inhibition of UVB-induced melanogenesis acts at the post-transcriptional level leading to a decreased tyrosinase and TRP-1 synthesis. We also show that in NHM, inhibition of TRP-2 following UVB-treatment is significantly reversed by RA. This demonstrates a negative correlation between melanogenesis and TRP-2 expression.

Melanocyte

10.1242/jcs.107.4.1095

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Citations (96)

Paysage, capital culturel et pouvoir

HAL (Le Centre pour la Communication Scientifique Directe) (2011)

Christine Roméro

L’article questionne l’impact de la production de discours savants sur le paysage, sur les itineraires des territoires ruraux. Outre les « grands paysages », les campagnes « banales » investies par des neos a haut capital culturel et social sont concernees par une situation qui met en scene des acteurs locaux, autochtones ou allochtones, mobilisant la revendication de deux types de savoirs, savoir scientifique versus savoir vernaculaire, et deux types d’attachement au lieu, l’appartenance choisie versus l’enracinement. La competence a tenir un discours savant sur le paysage s’avere un capital spatial permettant d’influer sur l’amenagement de l’espace. Fonde sur l’habilete des individus a mettre en œuvre, en fonction du contexte, telle ou telle facette de leur identite, il peut en resulter la promotion du lieu par labellisation de sa qualite et production d’une culture partagee. L’analyse est fondee sur un corpus d’entretiens et de publications emanant de collectivites et d’associations ainsi que sur la pratique de l’observation participante en reunions publiques.

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An Investigation of Alternative Language Services (ALS) Received by English Language Learners (ELLs) Identified with a Disability

Christine Roméro

Ell

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Paris-Orléans. La concurrence

HAL (Le Centre pour la Communication Scientifique Directe) (2018)

Christine Roméro Christophe Speroni

Concurrence

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ACKNOWLEDGMENTS

Columbia University Press eBooks (2022)

Stacey Abbott Peggy Ahwesh Terry Alexander Richard Allen Tanine Allison

This book took shape in ways that made it an unusually personal project, a work of scholarship tied to my everyday life more intimately than ever before.I would not have dared to make the book as close to me as it is without the support of an extraordinary network of colleagues, students, friends, and family who believed in me, in the project, and in horror studies as the connective tissue between the two.Given the blurring between my personal and professional lives that characterized the creation of this book from start to finish, I cannot hope to thank everyone who contributed to its coming into being; each one of you has my deepest gratitude,

10.7312/lowe20576-002

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Caracterização molecular e microscópica da resistência à Ferrugem asiática da soja mediada pelo gene RPP4.

Aguida Maria Alves Pereira Morales Adriano Alves Pereira Stella Layse da Silva Lima Brito Christine Roméro Aluízio Borém

Cinco genes de resistencia a ferrugem asiatica foram identificados em soja: Rpp1, Rpp2, Rpp3, Rpp4 e Rpp5. Para obter maiores informacoes sobre a funcao dos genes Rpp4 candidatos, o presente trabalho teve como objetivo analisar o perfil microscopico da interacao planta patogeno atraves de analises microscopicas alem de analisar o padrao de expressao dos genes Rpp4 candidatos em diferentes tempos apos inoculacao atraves da tecnica de PCR quantitativo em tempo real (RT-qPCR), durante a interacao com o fungo. Entre os periodos de 24, 48, 72, 96, 120 hai, nao foi observado nenhuma diferenca significativa de expressao entre o material inoculado quando comparado com o falso inoculado. Entretanto nos horarios de 308 e 504 horas apos a inoculacao podemos observar que os genes Rpp4 candidatos tiveram a expressao induzida em 1,88 e 2,16 vezes quando comparado com o material falso inoculado. Na analise microscopica, P. pachyrhizi iniciou o processo de penetracao 9 hai, sendo observados pontos de perfuracao no tecido foliar proximos as juncoes celulares. Transcorrida 12 horas da inoculacao, foi possivel visualizar a formacao da hifa primaria de infeccao. A colonizacao do mesofilo avancou nas horas subsequentes, sendo que em 72 hai foi possivel observar o mesofilo bem colonizado por hifas septadas de P. pachyrhizi. Estes estudos permitiram melhor compreender os mecanismos moleculares no envolvimento da interacao entre soja e P. pachyrhizi.

Phakopsora pachyrhizi

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La production et l’appropriation de territoires par les néo-ruraux et leurs impacts paysagers

José Chaboche Christine Roméro

Appropriation

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La mémoire des lieux de la guerre de 1870. Transmission, représentations et usages

Christine Roméro

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Comprendre la sécheresse comme un phénomène physique vécu par les agriculteurs : une nécessité pour la gestion de l'adaptation et le développement rural durable. Le cas de la Beqaa centrale au Liban

Dynamiques environnementales (2021)

Tarek Nasser Laurent Touchart Ghaleb Faour Christine Roméro

The relationship between agriculture and its natural environment is an important starting point for defining drought from an agricultural perspective. Indeed, farmers may perceive drought, as a climatic risk, differently. This could depend on the physical environment of the farmer, the type and degree of involvement in his agricultural activities as well as the level of impact on his financial well-being (Ashraf and Routray, 2013). In Lebanon and particularly in the Beqaa plain, the majority of agricultural areas are strongly related to groundwater resources during the summer period. Due to the lack of sustainable local development, these resources would be threatened in the case of a probable climate change or a human factor allowing a possible evolution of water stress in the region. Questioning the origin of this phenomenon and its definition from the farmer's point of view can help us to better understand this problem. The objective of this study is therefore to identify the drought by crossing the human and physical elements in the perimeter of the study area.

Phenomenon

Agricultural Development

10.4000/dynenviron.5909

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