The demand for flexible microelectronics has increased significantly within the last decade. This study investigates the cooling performance of flexible pulsating heat pipes (PHPs) made from acrylic with a bend radius of ≈300 mm. The fabricated devices support two-phase, pulsating fluid flow inside the rectangular microchannels. Both water and ethanol are used as coolants, where local hot spots are generated by cobalt-alloy foil heaters inside the flexible PHPs. The PHP's dissipate the heat generated to the environment via copper condensers with controlled setpoint temperatures. Based on a heater surface area of ≈1.5 cm 2 and a condenser setpoint temperature of 25°C, the maximum heat flux observed for sustained and repeatable cooling with water and ethanol was 8 W /cm 2 . These heat fluxes correlate well with other PHP studies with similar heater power loads, channel geometries, and coolants.