Aibing Wu

Central People's Hospital of Zhanjiang

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Zhixiong Yang

Guangdong Medical College

Weiren Luo

Southern University of Science and Technology

Weiyi Fang

TCM-Intigrated Cancer Center of Southern Medical University

Hualin Chen

Guangdong Medical College

Yanli Mo

Guangdong Medical College

Kunpeng Wu

Bristol-Myers Squibb (United States)

Shihao Huang

Guangdong University of Technology

Yiping Luo

Guangdong Medical College

Guanqi Dai

Southern Medical University

Shujun Li

First Affiliated Hospital of Xinxiang Medical University

Cooperative Institutions

Southern Medical University

Guangdong Medical College

Sun Yat-sen University

Nanfang Hospital

Peking University

Shanghai Jiao Tong University

Nanjing Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Huazhong University of Science and Technology

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Mettl3-Mediated M6a Modification Plays a Role in Lipid Metabolism Disorders and Progressive Liver Damage in Mice by Regulating Lipid Metabolism-Related Gene Expression

Guanqi Dai Yonglong Li Shihao Huang Xueyi Tu Zhihao Zhou

Lipid Metabolism Disorder

Metabolism disorder

10.2139/ssrn.4363559

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Aldehyde dehydrogenase 1, a functional marker for identifying cancer stem cells in human nasopharyngeal carcinoma

Cancer Letters (2012)

Aibing Wu Weiren Luo Qianbing Zhang Zhixiong Yang Gong Zhang

Homeobox protein NANOG

Stem cell marker

Side population

KLF4

10.1016/j.canlet.2012.11.046

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Citations (80)

Materials & Methods S2

Songtao Qi Ye Song Yuping Peng Wang Hao Long Hao

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Retraction Notice to: LINC00472 Acts as a Tumor Suppressor in NSCLC through KLLN-Mediated p53-Signaling Pathway via MicroRNA-149-3p and MicroRNA-4270

Molecular Therapy — Nucleic Acids (2022)

Ai-Mei Zou Xingli Liu Zong-Jiong Mai Junke Zhang Zhuohuan Liu

[This retracts the article DOI: 10.1016/j.omtn.2019.06.003.].

10.1016/j.omtn.2022.05.016

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Controversies regarding T status and N status for non-small cell lung cancer.

PubMed (2015)

Yanli Mo Jiayin Peng Wenmei Su Xinggui Chen Aibing Wu

According to the newest version of NCCN Clinical Practice Guidelines for Non-Small Cell Lung Cancer (NSCLC), increasing attentions are paid to the role of nodal status and other high-risk factors, including vascular invasion, wedge resection, tumors > 4 cm, visceral pleural involvement, and incomplete lymph node sampling in the individual clinical treatment. Precise definitions of T status and N status, closely associated with prognosis and treatment, are worth expanding further. However, complexity arises because no unity definition exists regarding individual T and N descriptors. In an attempt to explore the potential prognostic values of the T status and N status, we systematically review relevant literature and found that there still remained some disputes about the definitions and prognosis. The adjacent lobe invasion regarded as T2 or T3 has not been reached consensus yet so far. Lymph node spread patterns are associated with the treatment strategies of NSCLC. This review mainly focus on the role of T status and N status and tried to seek appropriate and individual treatment strategies in NSCLC.

Performance status

Wedge resection

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SHCBP1 promotes cisplatin induced apoptosis resistance, migration and invasion through activating Wnt pathway

Life Sciences (2019)

Aimei Zou Aibing Wu Meihua Luo Chengyu Zhou Yan Lu

10.1016/j.lfs.2019.116798

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Citations (31)

Knocking down CDK4 mediates the elevation of let-7c suppressing cell growth in nasopharyngeal carcinoma

BMC Cancer (2014)

Zhen Liu Xiaobin Long Cheng Chao Yan Chen Qiangyun Wu

Abstract Background CDK4 is a protein kinase in the CDK family important for G1/S phase cell cycle progression. However, the roles and molecular mechanisms of CDK4 triggering nasopharynx carcinogenesis are still unclear. Methods Lentiviral-vector mediated shRNA was used to suppress CDK4 expression and examine its molecular mechanisms. Using immunohistochemistry, we analyzed CDK4 protein expression in clinicopathologically characterized nasopharyngeal carcinoma (NPC) cases and nasopharyngeal tissues (NPs). Survival curves were plotted by the Kaplan-Meier method and compared using the log-rank test. Results In this investigation, we knocked down CDK4 expression and observed that NPC cell growth and cell cycle progression were significantly blocked by suppressing expression of CCND1, CDK6, and E2F1 as well as elevated p21 expression. Further, we found that reduced CDK4 expression elevated the expression of let-7c, a tumor-suppressive miRNA modulated by E2F1. We found that let-7c was markedly downregulated in NPC tissues compared to NPs and suppressed cell growth and cell cycle progression by modulating p15/p16/CDK4/E2F1 pathway. Finally, CDK4 protein was observed to be overexpressed in NPC tissues and could be considered an unfavorable prognosis factor for NPC patients although its independent prognostic value did not reach statistical significance (p = 0.087). Conclusions Our results demonstrated that overexpressed CDK4 is an unfavorable prognostic factor which suppresses the expression of tumor suppressive-factor let-7c through p21/CCND1/CDK6/E2F1 signaling, and inhibits cell proliferation by p15/p16/CDK4/E2F1 feedback signaling in NPC.

Cyclin-dependent kinase 6

Tumor progression

E2F1

10.1186/1471-2407-14-274

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Citations (27)

Discrete Element Modelling of Cotton Stalk and its Verification

SSRN Electronic Journal (2022)

Weisong Zhao Chen Mingjiang Jianhua Xie Aibing Wu Zhenwei Wang

The biomechanical properties of cotton stalk (CS) play an important role in the development of uprooting, crushing and processing machinery, as well as the comprehensive utilization of biomass resources. Obtaining a discrete element model that can accurately reflect the biomechanical properties of CS can provide the basis for virtual simulation of related operating machinery. This could be useful for the machinery such as CS uprooting and processing. In this study, a discrete element mechanical model of CS was developed by the combination of discrete element method(DEM) and physical experiment testing. Eleven initial factors were screened by Plackett-Burman design (P-BD). The influence law of contact parameters and bonding parameters on the compression force-deformation (F-x) curve was investigated by using climbing test design. A second-order regression model of the compressive peak force (FC) and bonding parameters was established according to the Central Composite Design (CCD) method, and the bonding parameters of CS discrete element model were calibrated. The optimal bonding parameters combination was determined based on the above study. This included: normal stiffness per unit area 9.72E9 N·m-3, shear stiffness per unit area 9.38E9 N·m-3, critical normal stress 8.43E7 Pa and bonded disc radius 0.66 mm. Compared to the compressive experimental results, the deviation of FC was 1.1%, the trend of F-x curve was consistent, and the error of the slope of the fitted equation in the elastic deformation stage(EDS) was 0.7%. Compared with the bending experimental results, the error of the peak bending force was 2.53%. The results show that the established DEM can be used to properly simulate the compression of CS and that the method of calibrating the parameters for accuracy is reasonable. The results are important for studying the biomechanical properties of CS and optimizing the mechanisms of CS uprooting and crushing.

Stalk

10.2139/ssrn.4157014

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Serum KL-6 in radioactive pneumonia with lung cancer

Guoji zhongliuxue zazhi (2013)

Ling-li Bao Aibing Wu Zhixiong Yang

Serum KL-6 is a category of glycoprotein coded by the epithelium of sticky protein 1(MUC1) gene,which has already been regarded as an indicator of interstitial lung diseases,and later found highly expressed in part of malignant tumor patients.In recent years,studies has found that serum KL-6 is associated with the incidence of radioactive pneumonia,and monitoring serum KL-6 can predict the occurrence of radioactive pneumonia as well assess the severity and prognosis of disease. Key words: Lung diseases, interstitial; Lung neoplasms; Serum KL-6; Radiation pneumonitis

Radiation Pneumonitis

MUC1

10.3760/cma.j.issn.1673-422x.2013.08.011

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[Protective effect of hydrogen sulfide on intestinal ischemia/reperfusion injury in rats by regulating c-Jun N-terminal kinase/activator protein-1 signaling pathway].

PubMed (2024)

Fei Tong Genlin Lu Aibing Wu Renya Jiang

To investigate whether hydrogen sulfide (H

c-jun

10.3760/cma.j.cn121430-20230606-00423

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