Fatima Kamal

Emory University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Viraj A. Master

Emory University

Dattatraya Patil

Emory University

A Medline

Emory University

Tao Dong

Southern University of Science and Technology

Hajime Tanaka

The University of Tokyo

Sohail Dhanji

University of Tennessee Health Science Center

Yasuhisa Fujii

Tokyo Medical and Dental University

Dhruv Puri

University of California, San Diego

Franklin Liu

University of Arizona

Benjamin N. Schmeusser

Emory University

Cooperative Institutions

University of California, San Diego

University of Alberta

Emory University

University of Calgary

UC San Diego Health System

Tokyo Medical and Dental University

Center Point

Saint Michael's Medical Center

Universidad Nacional Autónoma de México

Universidad del Noreste

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Use of Greater Wax Moth Larvae (Galleria mellonella) as an Alternative Animal Infection Model for Analysis of Bacterial Pathogenesis

Methods in molecular biology (2018)

Fatima Kamal Danielle L. Peters Jaclyn G. McCutcheon Gary B. Dunphy Jonathan J. Dennis

Galleria mellonella

Pathogenesis

Animal model

10.1007/978-1-4939-8940-9_13

Cite

Citations (6)

PD08-07 PREDICTIVE FACTORS FOR RECURRENCE AND OUTCOMES IN T1a RENAL CELL CARCINOMA: ANALYSIS OF THE INMARC (INTERNATIONAL MARKER CONSORTIUM FOR RENAL CANCER) DATABASE

The Journal of Urology (2023)

Franklin Liu Luke Wang Sohail Dhanji Margaret Meagher Jonathan A. Afari

You have accessJournal of UrologyCME1 Apr 2023PD08-07 PREDICTIVE FACTORS FOR RECURRENCE AND OUTCOMES IN T1a RENAL CELL CARCINOMA: ANALYSIS OF THE INMARC (INTERNATIONAL MARKER CONSORTIUM FOR RENAL CANCER) DATABASE Franklin Liu, Luke Wang, Sohail Dhanji, Margaret Meagher, Jonathan Afari, Cesare Saitta, Saeed Ghassemzadeh, Aastha Shah, Dhruv Puri, Mimi Nguyen, Kevin Hakimi, Benjamin Schmeusser, Rachel Greenwald, Alexandra Medline, Fatima Kamal, Adil Ali, Shohei Fukuda, Masaki Kobayashi, Wei Chen, Bo Fan, Yusuke Aida, Yuya Maezawa, Shintaro Asai, Hajime Tanaka, Dattatraya Patil, Yasuhisa Fujii, Viraj Master, and Ithaar Derweesh Franklin LiuFranklin Liu More articles by this author , Luke WangLuke Wang More articles by this author , Sohail DhanjiSohail Dhanji More articles by this author , Margaret MeagherMargaret Meagher More articles by this author , Jonathan AfariJonathan Afari More articles by this author , Cesare SaittaCesare Saitta More articles by this author , Saeed GhassemzadehSaeed Ghassemzadeh More articles by this author , Aastha ShahAastha Shah More articles by this author , Dhruv PuriDhruv Puri More articles by this author , Mimi NguyenMimi Nguyen More articles by this author , Kevin HakimiKevin Hakimi More articles by this author , Benjamin SchmeusserBenjamin Schmeusser More articles by this author , Rachel GreenwaldRachel Greenwald More articles by this author , Alexandra MedlineAlexandra Medline More articles by this author , Fatima KamalFatima Kamal More articles by this author , Adil AliAdil Ali More articles by this author , Shohei FukudaShohei Fukuda More articles by this author , Masaki KobayashiMasaki Kobayashi More articles by this author , Wei ChenWei Chen More articles by this author , Bo FanBo Fan More articles by this author , Yusuke AidaYusuke Aida More articles by this author , Yuya MaezawaYuya Maezawa More articles by this author , Shintaro AsaiShintaro Asai More articles by this author , Hajime TanakaHajime Tanaka More articles by this author , Dattatraya PatilDattatraya Patil More articles by this author , Yasuhisa FujiiYasuhisa Fujii More articles by this author , Viraj MasterViraj Master More articles by this author , and Ithaar DerweeshIthaar Derweesh More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003239.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Stage migration in renal cell carcinoma (RCC) has led to an increasing proportion of diagnoses at earlier clinical tumor stage. While thought of as being low risk, emerging knowledge about heterogeneity of RCC histologies and consequent impact on prognosis led us to further explore outcomes and predictive factors in T1a RCC patients treated with surgical resection. METHODS: The INMARC database was queried for patients with T1aN0M0 RCC (≤4 cm) who underwent surgery via partial or radical nephrectomy. Patients were stratified into two groups based on having recurrence (distant or loco-regional) or not. Primary outcome was overall survival (OS). Multivariate analyses (MVA) were performed to analyze clinicopathological variables associated with recurrence and identify predictors of recurrence, cancer-specific mortality (CSM), and all-cause mortality (ACM). Kaplan-Meier analyses (KMA) were conducted for survival assessment between histology types clear cell, chromophobe, papillary, and variant. RESULTS: We analyzed 1,878 patients (median follow up 53.6 months); 101 (5.4%) developed recurrence (median time to recurrence 19.3 months); 51.1% developed distant recurrence, 35.6% had loco-regional recurrence, and 13.9% experienced distant and loco-regional recurrence. MVA demonstrated age (HR=1.02, p=0.02), sex (HR=1.71, p=0.045), diabetes (HR=1.94, p=0.006), high/unclassified grade (HR=2.82-4.40, p<0.001-0.007), papillary (HR=0.37, p=0.013) and variant (HR=2.51, p=0.019) RCC as predictive factors for recurrence. MVA identified high/unclassified grade (HR=3.17-6.22, p=0.002-0.003) and papillary RCC (HR=0.12, p=0.036) as predictive factors for CSM. MVA for ACM demonstrated age (HR=1.03, p<0.001), non-Caucasian race (HR=0.85, p<0.001), high grade (HR=1.42, p=0.024), recurrence (HR=1.86, p=0.003), and GFR<45 (HR=2.89, p<0.001) to be independent risk factors. KMA comparing clear cell, papillary, chromophobe and variant RCC revealed significant differences for 5-year CSS (97.8% vs. 99.3% vs. 98.5% vs. 87.0%, p=0.018) and 5-year RFS (92.4% vs. 96.0% vs. 97.8% vs. 81.7%, p<0.001), but not 5-year OS (89.4% vs. 85.2% vs. 93.2% vs. 73.7%, p=0.34). CONCLUSIONS: We noted differential outcomes in T1a RCC based on histology and grade for recurrence and CSM, while renal functional decline in addition to pathological factors and recurrence were predictive for ACM. These findings suggest consideration to refine management and post treatment surveillance strategies in T1a RCC. Source of Funding: Stephen Weissman Kidney Cancer Research Fund © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e235 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Franklin Liu More articles by this author Luke Wang More articles by this author Sohail Dhanji More articles by this author Margaret Meagher More articles by this author Jonathan Afari More articles by this author Cesare Saitta More articles by this author Saeed Ghassemzadeh More articles by this author Aastha Shah More articles by this author Dhruv Puri More articles by this author Mimi Nguyen More articles by this author Kevin Hakimi More articles by this author Benjamin Schmeusser More articles by this author Rachel Greenwald More articles by this author Alexandra Medline More articles by this author Fatima Kamal More articles by this author Adil Ali More articles by this author Shohei Fukuda More articles by this author Masaki Kobayashi More articles by this author Wei Chen More articles by this author Bo Fan More articles by this author Yusuke Aida More articles by this author Yuya Maezawa More articles by this author Shintaro Asai More articles by this author Hajime Tanaka More articles by this author Dattatraya Patil More articles by this author Yasuhisa Fujii More articles by this author Viraj Master More articles by this author Ithaar Derweesh More articles by this author Expand All Advertisement PDF downloadLoading ...

10.1097/ju.0000000000003239.07

Cite

Citations (0)

Escherichia coli XL10-Gold Bacteria Produce Bacteriophage

Journal of Clinical Microbiology (2012)

Fatima Kamal Likui Zhang Linda J. Reha-Krantz

Site-directed mutagenesis (SDM) is a powerful method to introduce specific mutations into DNA sequences ([1][1]). Package inserts in commercial kits for SDM sold by Agilent Technologies (QuikChange methods) recommend the use of XL10-Gold ultracompetent bacteria ([2][2]). We find, however, that XL10-

10.1128/jcm.03104-12

Cite

Citations (3)

Differential Cellular Response to Translocated Toxic Effectors and Physical Penetration by the Type VI Secretion System

Cell Reports (2020)

Fatima Kamal Xiaoye Liang Kevin Manera Tong‐Tong Pei Haeun Kim

The type VI secretion system (T6SS) is a lethal microbial weapon that injects a large needle-like structure carrying toxic effectors into recipient cells through physical penetration. How recipients respond to physical force and effectors remains elusive. Here, we use a series of effector mutants of Vibrio cholerae to determine how T6SS elicits response in Pseudomonas aeruginosa and Escherichia coli. We show that TseL, but no other effectors or physical puncture, triggers the tit-for-tat response of P. aeruginosa H1-T6SS. Although E. coli is sensitive to all periplasmically expressed effectors, P. aeruginosa is most sensitive to TseL alone. We identify a number of stress response pathways that confer protection against TseL. Physical puncture of T6SS has a moderate inhibitory effect only on envelope-impaired tolB and rseA mutants. Our data reveal that recipient cells primarily respond to effector toxicity but not to physical contact, and they rely on the stress response for immunity-independent protection.

Cell envelope

10.1016/j.celrep.2020.107766

Cite

Citations (60)

Cannabis and the Anxiety of Fragmentation—A Systems Approach for Finding an Anxiolytic Cannabis Chemotype

Frontiers in Neuroscience (2018)

Brishna S. Kamal Fatima Kamal Daniel E. Lantela

Cannabis sativa is a medicinal herb with a diverse range of chemotypes that can exert both anxiolytic and anxiogenic effects on humans. Medical cannabis patients receiving organically grown cannabis from a single source were surveyed about the effectiveness of cannabis for treating anxiety. Patients rated cannabis as highly effective overall for treating anxiety with an average score of 8.03 on a Likert scale of 0 to 10 (0=not effective,10=extremely effective). Patients also identified which strains they found the most or least effective for relieving their symptoms of anxiety. To find correlations between anxiolytic activity and chemotype, the top four strains voted most and least effective were analyzed by HPLC-MS/MS to quantify cannabinoids and GC-MS to quantify terpenes. Tetrahydrocannabinol and trans-nerolidol have statistically significant correlations with increased anxiolytic activity. Guiaol, eucalyptol, γ-terpinene, α-phellandrene, 3-carene and sabinene hydrate all have significant correlations with decreased anxiolytic activity. Further studies are needed to better elucidate the entourage effects that contribute to the anxiolytic properties of cannabis varieties.

Chemotype

Eucalyptol

10.3389/fnins.2018.00730

Cite

Citations (45)

Isolation and Characterization of Cellulolytic Pseudomonas Aeruginosa from Teak Forest Soil for its Cellulase Production and Cellulolytic Activity

Chittagong University Journal of Biological Sciences (2024)

Fatima Kamal Faozia Faleha Sadida MA Manchur

A cellulolytic bacterium was isolated from Tectona forest soil and provisionally identified as Pseudomonas aeruginosa. The bacterium showed the highest level of reducing sugar and extracellular protein production when incubated for 3 days at 40°C, pH 8.5 in Winstead’s broth having 1.5% carboxymethyl cellulose (CMC) and 0.2% Yeast Extract as carbon and nitrogen sources, respectively. The bacterium produced the maximum 462 µg/ml reducing sugar and 450 µg/ml extracellular proteins. Crude cellulase produced by the bacterium showed the highest carboxymethyl cellulase (CMCase) activity rather than filter paperase (FPase), Avicelase and β-Glucosidase activities. The crude cellulase showed highest CMCase activity when incubated for 90 minutes at pH 8.5, 25°C using CMC and Yeast Extract as carbon and nitrogen sources, respectively as well as in presence of Hg2+ ion and SDS (inhibitor and reductant). The highest enzyme activity was found to be 315 U/ml. The molecular weight of the crude cellulase was found as 33 kDa through SDS PAGE analysis. According to Worthington Enzyme Manual it may be Endoglucanase IV. The Chittagong Univ. J. B. Sci., Vol. 10(1 &2):167-179, 2020

Isolation

10.3329/cujbs.v10i1.74252

Cite

Citations (0)

A Dehydrohalogenation Methodology for Synthesizing Terminal Olefins under Mild Conditions.

ChemInform (2007)

Marie Bérubé Fatima Kamal Jenny Roy Donald Poirier

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Dehydrohalogenation

10.1002/chin.200704048

Cite

Citations (5)

C6-(N,N-butyl-methyl-heptanamide) derivatives of estrone and estradiol as inhibitors of type 1 17β-hydroxysteroid dehydrogenase: Chemical synthesis and biological evaluation

Bioorganic & Medicinal Chemistry (2006)

Christine Cadot Yannick Laplante Fatima Kamal Van Luu‐The Donald Poirier

Side chain

Structure–activity relationship

Hydroxysteroid Dehydrogenases

Methyl group

IC50

10.1016/j.bmc.2006.10.055

Cite

Citations (33)

Nutritional Deficiencies Before and After Bariatric Surgery in Low- and High-Income Countries: Prevention and Treatment

Cureus (2024)

Faiza A Kamal Lucas Y Fernet Miguel Rodriguez Fatima Kamal Naofal K Da Silva

Nutritional deficiencies represent a prevalent concern among individuals with obesity, stemming from suboptimal dietary habits, chronic inflammation, and preoperative weight reduction efforts. Bariatric surgical interventions, employing either restrictive, malabsorptive or a combination of the two methods, further compound these deficiencies. Commonly observed nutritional deficits following bariatric surgeries include vitamin B12, vitamin D, thiamine, folate, iron, and protein deficiencies. These deficiencies are further complicated by disparities in healthcare resources and income that distinguish low, medium, and high-income countries. The escalating rates of obesity in low- and medium-income countries are primarily attributed to the increasing availability of cheap, nutritionally depleted, and processed foods, coupled with limited access to healthcare. The provision of bariatric surgical interventions in such regions is hindered by the lack of appropriately trained medical personnel and adequate infrastructure. Additionally, the crucial facets of postoperative care, including diligent follow-up, precise weight loss monitoring, and the administration of appropriate nutritional supplements, often remain lacking. This narrative review provides a comprehensive examination of the prevention and treatment of nutritional deficiencies before and after bariatric surgery in the context of varying healthcare resources and income levels. Bariatric procedures and their global prevalence are discussed, and the prevalence, symptoms, and management strategies of specific nutritional deficiencies are explained. This review also outlines practical strategies for providing more equitable care in low- and medium-income countries.

10.7759/cureus.55062

Cite

Citations (3)

Essential functions of chaperones and adaptors of protein secretion systems in Gram‐negative bacteria

FEBS Journal (2021)

Kevin Manera Fatima Kamal Brianne J. Burkinshaw Tao Dong

Equipped with a plethora of secreted toxic effectors, protein secretion systems are essential for bacteria to interact with and manipulate their neighboring environment to survive in host microbiota and other highly competitive communities. While effectors have received spotlight attention in secretion system studies, many require accessory chaperone and adaptor proteins for proper folding/unfolding and stability throughout the secretion process. Here, we review the functions of chaperones and adaptors of three protein secretions systems, type 3 secretion system (T3SS), type 4 secretion system (T4SS), and type 6 secretion system (T6SS), which are employed by many Gram‐negative bacterial pathogens to deliver toxins to bacterial, plant, and mammalian host cells through direct contact. Since chaperone and adaptor functions of the T3SS and the T4SS are relatively well studied, we discuss in detail the methods of chaperone‐facilitated effector secretion by the T6SS and highlight commonalities between the effector chaperone/adaptor proteins of these diverse secretion systems. While the chaperones and adaptors are generally referred to as accessory proteins as they are not directly involved in toxicities to target cells, they are nonetheless vital for the biological functions of the secretion systems. Future research on biochemical and structural properties of these chaperones will not only elucidate the mechanisms of chaperone‐effector binding and release process but also facilitate custom design of cargo effectors to be translocated by these widespread secretion systems for biotechnological applications.

Gram-Negative Bacteria

Gram

Chaperone (clinical)

10.1111/febs.16056

Cite

Citations (23)