Keshav Kumar

Indira Gandhi Institute of Medical Sciences

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Shrushti Bhamble

National Institute of Pharmaceutical Education and Research

Vikas Maharshi

All India Institute of Medical Sciences

Nicoleta Negruț

University of Oradea

Aayush Sehgal

Chitkara University

Sanyog Jain

National Institute of Pharmaceutical Education and Research

Camelia Liana Buhaș

University of Oradea

Kumar Martand

ESI - Post Graduate Institute of Medical Science and Research

Oly Katari

National Institute of Pharmaceutical Education and Research

Alok Kumar

All India Institute of Medical Sciences Bhopal

Sayali Dighe

National Institute of Pharmaceutical Education and Research

Cooperative Institutions

University of Oradea

All India Institute of Medical Sciences

All India Institute of Medical Sciences Bhopal

All India Institute of Medical Sciences Raipur

National Institute of Pharmaceutical Education and Research

Chitkara University

University of Petroleum and Energy Studies

University of Nizwa

Iuliu Hațieganu University of Medicine and Pharmacy

Government of Himachal Pradesh

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Revolutionizing Cancer Management: Cutting-Edge Techniques for Nanophotosensitizer Delivery in Photodynamic Therapy

Journal of Drug Delivery Science and Technology (2025)

Shrushti Bhamble Keshav Kumar Pranayee Datta Sayali Dighe Sanyog Jain

Cancer Therapy

10.1016/j.jddst.2025.106665

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Unveiling the role of polyphenols in diabetic retinopathy

Journal of Functional Foods (2021)

Tapan Behl Keshav Kumar Sukhbir Singh Aayush Sehgal Monika Sachdeva

Diabetes retinopathy (DR) is the leading cause of blindness and is considered as the most ordinary microvascular complication of diabetes mellitus (DM). The current available therapies can only be effective in the progressive stages of DR and there are various clinical studies which depicts the inconclusive outcomes of these available therapies after assessing the long-term efficacy and safety of such treatments. Moreover, there is an indispensable need of a more reliable as well as potent treatment which can be considered as more efficacious treatment for the management of DR. The treatment of DR can be possible at the early stages with polyphenols which are plant derived chemical agents and can be act as an alternative to other treatments and can optimistically prevent the further evolution of disease. The present review emphasizes the role of polyphenols on cellular and molecular mechanisms altered by DR in preclinical and clinical studies.

10.1016/j.jff.2021.104608

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Risk of Congenital Anomalies with Dolutegravir-Based Anti-retroviral Regimens: A Systematic Review and Meta-analysis

Clinical Drug Investigation (2024)

Shuvasree Payra Divya Harsha Keshav Kumar Pramod Kumar Manjhi Shruti Singh

Dolutegravir

Pharmacotherapy

10.1007/s40261-024-01390-y

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Gemini surfactants as next-generation drug carriers in cancer management

Expert Opinion on Drug Delivery (2024)

Oly Katari Keshav Kumar Shrushti Bhamble Sanyog Jain

Introduction Gemini surfactants (GS) are an elite class of amphiphilic molecules that have shown up as a potential candidate in the field of drug delivery because of their exceptional physicochemical properties. They comprise two hydrophilic headgroups connected by an adaptable spacer and hydrophobic tails that has shown promising results in delivering different therapeutic agents to cancer cells at preclinical level. However further studies are in demand to unlock the full potential of GS in this field.

10.1080/17425247.2024.2384037

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Pharmacotherapy of postpartum depression: An update

Indian Journal of Obstetrics and Gynecology Research (2025)

Keshav Kumar Kumari Pallavi Kumar Martand Vikas Maharshi

Postpartum depression (PPD) is a mood disorder with depressive symptoms during perinatal period. It negatively impacts women, child, family, and society and hence must be promptly diagnosed and adequately treated. Etiopathogenesis of postpartum depression is not known but is hypothesized to be a complex interplay among various maternal, biological, psychosocial, and genetic factors. Maternal factors encompass high or tender age at pregnancy, while the biological factors include fluctuation of hormones like estrogen and progesterone during perinatal period and dysfunction of HPA-axis. Recognized psychosocial factors are history of depression, symptoms of depression or anxiety during pregnancy, stressful life events and postpartum blue symptoms, single status, lower educational level, multiple offsprings, poor marital relationship and low socioeconomic status. Genetic variations in hemicentin-1 (HMCN1) gene have been found to have increased susceptibility to PPD. Women with PPD presents with fatigue, sadness anhedonia, impaired concentration, irritability, guilt, psychomotor agitation, sleep disturbances and changes in appetite and weight. Management of PPD is a multidisciplinary approach and encompasses complementary health practices, psychological interventions, pharmacotherapy, and somatic therapy. Complementary health practices are educating women about self-care and about growing treatment-seeking behaviour. Cognitive behavioral therapy (CBT) and Interpersonal psychotherapy (IPT) are specifically adapted and well-studied psychological interventions for PPD. Many drugs like antidepressants, estrogen and progesterone have been used for long time for treatment of PPD but their use has not been approved by any regulatory authorities. The First drug approved by U.S. Food and Drug Administration (US FDA) for PPD was brexanolone which is an injectable. Zuranolone is recent addition to this approved category and is an oral one. Both brexanolone and zuranolone are indicated for severe PPD where psychological interventions and antidepressants are usually ineffective.

Pharmacotherapy

Depression

10.18231/j.ijogr.2025.001

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