Boli Zhang

Sichuan University

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Junhua Zhang

Tianjin University of Traditional Chinese Medicine

Hongcai Shang

Beijing University of Chinese Medicine

Xiumei Gao

Tianjin University of Traditional Chinese Medicine

Fang Yu

Dalian Polytechnic University

Hongyan Liu

China Population and Development Research Center

Hongpeng Fu

National Health and Family Planning Commission

Yan Hou

Shanghai University

Zhongfan Wang

National Health and Family Planning Commission

Chuanqi He

Massachusetts Institute of Technology

Ming Xue

Hangzhou Center for Disease Control and Prevention

Cooperative Institutions

Tianjin University of Traditional Chinese Medicine

190

Chinese Academy of Medical Sciences & Peking Union Medical College

152

Chinese Academy of Sciences

104

Sichuan University

102

Shanghai Jiao Tong University

Capital Medical University

Peking University

Sun Yat-sen University

Zhejiang University

Fudan University

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Clinical practice guideline on traditional Chinese medicine therapy alone or combined with antibiotics for sepsis

Annals of Translational Medicine (2019)

Guozhen Zhao Renbo Chen Bo Li Yuhong Guo Yan‐Ming Xie

To develop the clinical practice guidelines for the treatment of sepsis with traditional Chinese medicine (TCM) therapy alone or TCM combined with antibiotics. The methods and process for developing the international clinical practice guidelines were fully consulted between a group of doctors. A total of 25 experts from 14 units were involved in the development of this guideline. The major clinical questions that needed to be solved were raised first, and the best available evidence to solve them was researched. Finally, according to the principle set by the GRADE system, the available evidence was graded with levels ranging from high to low. This formed the recommendation strengths, which included strong recommendation and weak recommendation, or an expert consensus recommendation. The guideline identified the terms and definition for sepsis. For example, it identified its epidemiological characters, the advantages of TCM treatment on sepsis, the diagnosis and its features, the complications, and its rehabilitation and health maintenance. The guideline has put forward 14 recommendations, among which 4 were strong recommendations and 6 were weak recommendations, in addition to 4 expert consensus recommendations. The methods and processes for developing international clinical practice guidelines were fully consulted under the guide of relevant laws and regulations, and relevant technical documents. Based on the best existing evidence, and combined with the characteristics of TCM and the clinical realities, we developed Clinical practice guidelines for the treatment of sepsis with TCM therapy alone or TCM combined with antibiotics, with full reference to the experts' experience and patients' preferences.

Guideline

Clinical Practice

10.21037/atm.2018.12.23

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Citations (29)

Assessment of complementary treatment with Yiqi Fumai lyophilized injection on acute decompensated ischemic heart failure (ACT-ADIHF): a multicenter randomized controlled trial

Research Square (Research Square) (2023)

Xianliang Wang Zhiqiang Zhao Xiaofeng Wang Yue Deng Yong Hong Xu

Abstract Background To evaluate the efficacy and safety of Yiqi Fumai lyophilized injection in treating acute decompensated ischemic heart failure (ADIHF). Methods 666 patients with ADIHF from 37 clinical research centers in China were randomly allocated to the treatment group (n = 332) and the control group (n = 334). The control group was treated with standardized western medicine. The treatment group received intravenously 5.2g Yiqi Fumai lyophilized injection based on standardized western medicine for 7 days. Results There was no statistically significant difference in baseline characteristics between the two groups ( P > 0.05). After treatment, the BNP level in the treatment group was significantly lower than that in the control group (8 days: 465.0 pg/ml vs. 533.6 pg/ml, P < 0.05; 60 ± 3 days: 398.0 pg/ml vs. 464.0 pg/ml, P < 0.01). The percentage of BNP level reduced by more than 30% compared to baseline was significantly higher in the treatment group than that in the control group ( P < 0.01). And the improvement of LVEF, NYHA cardiac functional classification, MLHFQ score, and TCM four diagnosis information score were better in the treatment group than those in the control group at 60 ± 3 days after enrollment ( P < 0.05 or P < 0.01). There were no statistically significant differences in the incidence of composite endpoint events and adverse events ( P > 0.05). Conclusion Based on standardized western medicine, using Yiqi Fumai lyophilized injection can further reduce the plasma BNP level, improve cardiac function, alleviate clinical symptoms, improve the quality of life in patients with ADIHF, and it is safe.

Clinical endpoint

10.21203/rs.3.rs-3093131/v1

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Simultaneous determination of active flavonoids and alkaloids of Tang-Min-Ling-Pill in rat plasma by liquid chromatography tandem mass spectrometry

Journal of Chromatography A (2012)

Yonghong Zhu Ling Tong Shuiping Zhou He Sun Kaishun Bi

Coptisine

Jatrorrhizine

Tetrahydropalmatine

Hesperetin

Coptis chinensis

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UPLC/Q-TOF-MS-based chemical profiling approach to evaluate the chemical constitution of Radix Aconiti Lateralis Preparata in the process of decoction

Journal of Chinese Integrative Medicine (2012)

Sisi Zhou Zeng-Chun Ma Qiande Liang Yuguang Wang Hong-Ling Tan

Aconitine

Radix (gastropod)

Decoction

10.3736/jcim20120810

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Chinese medicine industry 4.0:advancing digital pharmaceutical manufacture toward intelligent pharmaceutical manufacture

China Journal of Chinese Materia Medica (2016)

Yiyu Cheng Haibin Qu Boli Zhang

A perspective analysis on the technological innovation in pharmaceutical engineering of Chinese medicine unveils a vision on "Future Factory" of Chinese medicine industry in mind. The strategy as well as the technical roadmap of "Chinese medicine industry 4.0" is proposed, with the projection of related core technology system. It is clarified that the technical development path of Chinese medicine industry from digital manufacture to intelligent manufacture. On the basis of precisely defining technical terms such as process control, on-line detection and process quality monitoring for Chinese medicine manufacture, the technical concepts and characteristics of intelligent pharmaceutical manufacture as well as digital pharmaceutical manufacture are elaborated. Promoting wide applications of digital manufacturing technology of Chinese medicine is strongly recommended. Through completely informationized manufacturing processes and multi-discipline cluster innovation, intelligent manufacturing technology of Chinese medicine should be developed, which would provide a new driving force for Chinese medicine industry in technology upgrade, product quality enhancement and efficiency improvement.

Digital Manufacturing

Factory (object-oriented programming)

10.4268/cjcmm20160101

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Citations (7)

Strengthening Organization and Implementation

Springer eBooks (2020)

Bin Li Xiaowei Ma Yonghui Yu Guodong Wang Ning Zhuang

Blueprint

10.1007/978-981-32-9603-9_22

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The therapeutic effects of qigong in patients with chronic obstructive pulmonary disease in the stable stage: a meta-analysis

BMC Complementary and Alternative Medicine (2019)

Hongxuan Tong Yihua Liu Yutian Zhu Boli Zhang Jingqing Hu

Chronic obstructive pulmonary disease (COPD) is one global disease. Lung function gradually declines. Medication does not fully reverse the airflow limitation. Qigong's role in COPD rehabilitation has been assessed. We aimed to assess the effects of Qigong practised by COPD patients. Eligible articles were obtained through a systematic search. The databased were search on October 8, 2017, and the date range of the searches in the electronic databases had no upper limit. The Cochrane risk-of-bias tool was used to evaluate the quality of the eligible studies. Mean differences with 95% confidence intervals were utilized to analyse the results. Ten included studies contained 993 participants. Statistical improvements occurred in the 6-min walk distance (6MWD) (MD, 30.57 m; 95% CI, 19.61–41.53 m; P < 0.00001); forced expiratory volume in 1 s (FEV1) (MD, 0.32 L; 95% CI, 0.09–0.56 L; P < 0.001); forced vital capacity rate of 1 s (FEV1/FVC) (MD, 2.66%; 95% CI, 1.32–2.26%; P = 0.0001); forced expiratory volume in 1 s/predicted (FEV1/pre) (MD, 6.04; CI, 2.58–9.5; P = 0.006); Monitored Functional Task Evaluation (MD, 0.88; 95% CI, 0.78–0.99; P < 0.00001); COPD Assessment Test for exercise (MD, − 5.54; 95% CI, − 9.49 to − 1.59; P = 0.006); Short Form-36 Health Quality Survey (SF-36)–General Health (MD, 5.22; 95% CI, 3.65–6.80; P < 0.00001); and Short Form-36 Health Quality Survey (SF-36)–Mental Health (MD, − 1.21; 95% CI, − 2.75 to 0.33; P = 0.12). In this meta-analysis of RCTs between ten included studies, we found that Qigong can improve COPD patients in lung function, exercise capacity and quality of life who were in the stable stage.

Vital capacity

10.1186/s12906-019-2639-9

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Citations (39)

Letting Traditional Chinese Medicine Play Its Unique Role

Springer eBooks (2020)

Bin Li Xiaowei Ma Yonghui Yu Guodong Wang Ning Zhuang

Treasure

10.1007/978-981-32-9603-9_10

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Citations (1)

Simultaneous determination of active flavonoids and alkaloids of Tang-Min-Ling-Pill in rat plasma by liquid chromatography tandem mass spectrometry