Carmen Monica Pop

Iuliu Hațieganu University of Medicine and Pharmacy

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Milena Adina Man

Iuliu Hațieganu University of Medicine and Pharmacy

NȘ

Nicoleta Ștefania Motoc

Iuliu Hațieganu University of Medicine and Pharmacy

Doina Adina Todea

Iuliu Hațieganu University of Medicine and Pharmacy

Ana Florica Chiş

Iuliu Hațieganu University of Medicine and Pharmacy

Maria Wetscherek

Cambridge University Hospitals NHS Foundation Trust

Ruxandra Râjnoveanu

Iuliu Hațieganu University of Medicine and Pharmacy

Andrei Leșan

Iuliu Hațieganu University of Medicine and Pharmacy

Daniela Homorodean

Clinica de Pneumologie Iaşi

Bianca Domokos Hancu

Iuliu Hațieganu University of Medicine and Pharmacy

Beatrice Mahler

Carol Davila University of Medicine and Pharmacy

Cooperative Institutions

Iuliu Hațieganu University of Medicine and Pharmacy

Clinical Emergency Hospital Bucharest

Carol Davila University of Medicine and Pharmacy

Clinica de Pneumologie Iaşi

Grigore T. Popa University of Medicine and Pharmacy

Charité - Universitätsmedizin Berlin

Heidelberg University

Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi

University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca

University Hospital Heidelberg

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Pulmonary tuberculosis: Something old, something new, something borrowed, something blue

Maria Wetscherek Mihaela Coman Maria Magdalena Duma Adriana Calin S Sfrangeu

Poster: ECR 2015 / C-1999 / Pulmonary tuberculosis: Something old, something new, something borrowed, something blue by: T. A. Buzan1, M. M. Coman2, M. M. Duma3, A. M. Calin3, S. A. Sfrangeu3, C. M. Pop3; 1Blaj/RO, 2Campia Turzii/RO, 3Cluj-Napoca/RO

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Disease perception and coping with emotional distress during COVID-19 pandemic

Authorea (Authorea) (2020)

Milena Adina Man Claudia Toma Nicoleta Ștefania Motoc Viana Necrelescu Cosmina Ioana Bondor

Background: The novel coronavirus disease, COVID 19, is a highly contagious infectious disease declared by the World Health Organization pandemic and a global public health emergency. During outbreaks, health care workers are submitted to enormous emotional burden as they must balance the fundamental "duty to treat" with the parallel duty to family and loved ones. The aims of our study is to evaluate disease perceptions, levels of stress, emotional distress, and coping strategies among medical staff (COVID 19 versus non-COVID 19 department) in tertiary pulmonology teaching hospital in the first month after the outbreak of COVID 19. Methods: One hundred fifteen health care workers completed four validated questionnaires (the brief illness perception questionnaire, perceived stress scale, the profile of emotional distress emotional, cognitive coping evaluation questionnaire) that were afterward interpreted by one psychologist. Results: There was a high level of stress and psychological distress among health care workers in the first month after the pandemic outbreak. Interestingly, there was no difference between persons that work on COVID 19 department versus those working in non-COVID 19 department. Disease perceptions and coping mechanism were similar in the two groups. As coping mechanism, refocusing on planning and positive reappraisal were used more than in general population. Conclusions: there is no difference in disease perceptions, levels of stress, emotional distress, and coping strategies in medical staff handling COVID 19 patients versus personal that does not handle COVID patients the first month after the pandemic outbreak

Pandemic

10.22541/au.159242059.92923486

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Non-invasive ventilation in acute exacerbation of chronic obstructive pulmonary disease: pressure support versus volume assured pressure support

Health Sports & Rehabilitation Medicine (2019)

Nicoleta Ștefania Motoc Teodora Alexescu Carmen Monica Pop

Pressure support ventilation

Positive pressure ventilation

10.26659/pm3.2019.20.3.139

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Spectrum of diagnostic findings in idiopathic pulmonary fibrosis assessed by lung MRI – a pictorial essay

Maria Wetscherek Julien Dinkel Monika Eichinger Hans‐Ulrich Kauczor Michael Kreuter

Poster: ECR 2016 / C-1339 / Spectrum of diagnostic findings in idiopathic pulmonary fibrosis assessed by lung MRI – a pictorial essay by: T. A. Buzan1, J. Dinkel2, M. Eichinger2, H. U. Kauczor2, M. Kreuter2, F. J. Herth2, C. M. Pop1, C. P. Heussel2; 1Cluj-Napoca/RO, 2Heidelberg/DE

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Neutrophil-to-Lymphocyte Ratio and Platelets-to-Lymphocytes Ratio in severe COPD exacerbation: the importance of obstructive sleep apnea

05.02 - Monitoring airway disease (2019)

Nicoleta Ștefania Motoc Milena Adina Man Andrada Elena Campean Urda Victoria Maria Ruta Doina Adina Todea

Neutrophil-to-Lymphocyte Ratio (NLR) and Platelets-to-Lymphocytes Ratio (PLR) are new inflammatory markers with prognostic significance in a number of inflammatory diseases. Several studies showed that their values are higher in COPD patients when compared with general population, and its values increase even more in COPD exacerbation. NLS it's also a surrogate marker of obstructive sleep apnea severity, and it increases with obesity. The purpose of this paper is to evaluate NLR and PLR values in patients with overlap syndrome hospitalized for COPD exacerbation. 37 patients with newly diagnosed OSA-COPD overlap syndrome patients and 44 patients with COPD consecutively hospitalized for severe COPD exacerbation were included. Complete blood cell counts and differential values were recorded. NLR and PLR were calculated from absolute neutrophil and lymphocyte counts from CBC. Both group had the same GOLD stage FEV1= 47.44±18.82 in OSA-COPD group and 48.18±29.09% in COPD group. They all had at least one exacerbation in the previous 12 months. Sleep apnea syndrome was moderate and severe. In patients with overlap syndrome median NLR was 5.13±4.6, while patients with COPD had higher values 7.24±7.27 (p=0.041). When considering PLR there was no statistical difference among the 2 groups: 133.49 +/84.81 compared with 158.48 +/-89.14 in COPD groups. Patients with COPD alone had more severe inflammation, with higher values of NLS when compared with OSA-COPD patients. This may be a consequence of protective effect of obesity in these patients. Further studies on larger population are required.

Overlap syndrome

10.1183/13993003.congress-2019.pa2582

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Neutrophil-to-lymphocyte ratio (NLR) and Platelets-to-lymphocyte (PLR) Ratio in Patients with Exacerbation of Bronchiectasis

Revista de Chimie (2019)

Nicoleta Ștefania Motoc Paula Martinovici Beatrice Mahler I Tudorache Tudor Harsovescu

Neutrophil-to-lymphocyte ratio (NLR) and platelets-to-lymphocyte ratio(PLR) are novel inflammatory markers used in evaluation of systemic inflammation. The aim of this study was to evaluate the utility of NLR and PLR as inflammatory markers in patients with exacerbation of bronchiectasis. 100 patients with age between 23 and 88 years old with chest CT documentated bronchiectasis were included. Blood test were collected at admission in the hospital. There was a good correlation between classical markers such as CRP, ESR, white blood cells and NLR. PLR, however correlated only with ESR from the inflammatory markers and with the values og hemoglobin and hematocrit. We did not see higher values in patients with COPD and bronchiectasis when compared with patients with bronchiectasis alone, howevere patients with COPD GOLD stage 2 and bronchiectasis had higher values of NLR and PLR when compared with other stages. NLR, more than PLR can be safley used in evaluating inflammation in patients with exacerbation of bronchiectasis.

10.37358/rc.19.11.7665

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Increased Vascular Endothelial Growth Factor Serum Level and the Role of +936C/T Gene Polymorphism in Chronic Obstructive Pulmonary Disease

Medicina (2021)

Ana Florica Chiş Ruxandra Râjnoveanu Milena Adina Man Doina Adina Todea Bogdan Augustin Chiș

Background and Objectives: Chronic obstructive pulmonary disease (COPD) represents a debilitating disease, with rising morbidity and mortality. Vascular endothelial growth factor (VEGF) plays a major role in angiogenesis, vascular permeability, and airway remodeling. The purpose of this study was to investigate the relationship between VEGF serum levels and VEGF +936 C/T gene polymorphism (rs3025039) with COPD, for the first time in a Romanian population. Materials and Methods: In total, 120 participants from Transylvania were included in this case-control study. Serum levels of VEGF were determined using an enzyme-linked immune-sorbent assay and rs3025039 was investigated by high molecular weight genomic deoxyribonucleic acid (DNA). Spirometric values, arterial blood gas analysis, and the Six Minute Walk Test (6MWT) outcome were also determined. Results: The serum level of VEGF was higher in the COPD group versus controls (p < 0.001), with a positive correlation with the 6MWT outcome. No significant difference was observed in the VEGF serum levels between VEGF +936C/T genotypes. There was no difference in the VEGF +936C/T genotype between COPD patients and healthy subjects (chi2 test p = 0.92, OR = 1.04, 95%CI = 0.41-2.62), but the presence of the T allele was significantly linked to the presence of COPD (chi2 test p = 0.02, OR = 2.36, 95%CI = 1.12-4.97). Conclusions: Higher VEGF serum levels were found in moderate and severe COPD and were positively correlated with the distance in the 6MWT. No significant difference was found between CC, CT, and TT genotypes of rs3025039 and the presence of COPD. The presence of the T allele was found to be linked to COPD and also to the degree of airway obstruction.

10.3390/medicina57121351

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STUDY OF CORRELATION BETWEEN SEVERAL DIAGNOSTIC TESTS FOR LATENT TUBERCULOSIS

Amalia Ioana G Carmen Monica Pop

Summary Tuberculosis (TB) is a disease caused by bacteria n amed Mycobacterium tuberculosis (MT) and it has a global impact on health. Our aim was to evaluate the performance of several tests for latent TB diagnosis. We determine d the accuracy of tuberculin skin test (TST) and QuantiFERON-TB Gold (QFT-G) for diagnosis of TB, by comparing data obtained from two groups: one with active TB and one without active TB, but with a high risk of TB infection. For active TB we calculated f or TST a sensitivity of 88.2%, a specificity of 72.3%, a positive predictive value o f 86.6% and a negative predictive value of 75%. %. For active TB we calculated for QFT-G a sensitivity of 82.3%, a specificity of 94.5%, a positive predictive value of 85% and a negative predictive value of 93.3%. Also, we found a fair agreement between QFT-G and TST (k=0.384; p=0.01). We demonstrated the high accuracy of QFT-G for immunologic diagnosis of TB in a

Active tuberculosis

QuantiFERON

Tuberculosis diagnosis

Gold standard (test)

Skin test

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Six-minute walk test outcome in COPD patients

Palestrica of the third millennium - Civilization and Sport (2018)

Ana Florica Chiş Ruxandra Râjnoveanu Milena Adina Man Doina Adina Todea Bogdan Augustin Chiș

10.26659/pm3.2018.19.3.170

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MORBIDITY BY TUBERCULOSIS IN THE JIU VALLEY: RELATION WITH DIAGNOSTIC PRACTICE AND THE IMPACT ON THERAPEUTIC RESULTS

Medicine and Pharmacy Reports (2016)

Nicolae Petre Daniela Homorodean Carmen Monica Pop

In the last two and a half decades the dynamics of tuberculosis has been modelled by social and economic conditions, with consequences on the life style, and effects on the onset and evolution of the disease. The Jiu Valley is an area with social problems: mining, mines closing down and ceasing activity, poverty. We looked for a relationship between changes of life style in the Jiu Valley and the dynamics of tuberculosis.We studied 528 patients who asked for medical services in different hospitals in the Jiu Valley between 2010-2013. We structurally characterized this group, we identified the characteristics of life style, and we assessed the health state, in particular the relation with tuberculosis.We found out that the quality of life was influenced by the health state, especially by tuberculous disease. Quality of life was influenced by the life style, professional factors and their long term consequences. The study evidenced a strong relationship between apparently very different factors such as life style, professional factors on one side and those characterizing tuberculosis.We report the first detailed epidemiological data on tuberculosis in an economically poor area, the Jiu Valley.

10.15386/cjmed-649

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