To study the treatment of advanced lung adenocarcinoma in the elderly with pemetrexed combined with platinum drugs. 200 elderly patients who had been treated for advanced lung adenocarcinoma in our hospital were enrolled as research objects. They were randomly divided into control group and research group, each containing 100 patients. The control group was given Pemetrexed therapy and routine nursing mode, while the research group was given pemetrexed combined with platinum drugs and evidence-based nursing mode. The therapeutic effect and nursing effect of the two groups were compared. The overall treatment effective rate of the research was 85.00% and that of the control group was 60.00%, indicating the research group had significant advantage over the control group, p<0.05. The incidence of adverse reactions including nausea, vomiting, constipation, diarrhea, bone marrow suppression, fatigue and fatigue, and hair loss was significantly lower in the research group (22.00%) than that in the control group (45.00%), p<0.05. The quality of life of the research group was higher than that of the control group, p<0.05. For the elderly patients with advanced lung adenocarcinoma, the implementation of pemetrexed combined with platinum drug can help patients get better treatment results.
: This study aimed to evaluate changes in fusional vergence after strabismus surgery and to explore predictive parameters and the impact of fusional vergence on surgical outcomes. All patients diagnosed with intermittent exotropia (IXT) between March 2015 and October 2017 were included. Orthoptic assessments, including visual acuity, cover test, and mean fusional vergence (breakage/recovery, both negative and positive), were measured using a synoptophore. Subjects with symptomatic exotropia who underwent strabismus surgery were included. The primary outcome measure was the surgical success (SS) rate at a 6-month follow-up, with adverse effects such as over-correction and under-correction also evaluated. Data were analyzed using SPSS version 20.0. Surgical success was achieved in 62 patients (75.61%) at the 6-month follow-up. The postoperative fusional divergence breakpoints for the SS group and the surgical failure (SF) group were -7.52 ± 4.14 degrees and -10.00 ± 5.96 degrees (P = 0.040), respectively. The postoperative fusional convergence breakpoints for the SS group and the SF group were 10.03 ± 4.36 degrees and 4.65 ± 7.27 degrees (P < 0.001), respectively. The postoperative amplitude of fusional divergence was higher in the SS group compared to the SF group (P = 0.008). There was a significant difference in the duration of deviation (2.08 ± 0.84 vs. 4.23 ± 1.36, P < 0.001) between the groups, suggesting that the success rate of surgery is affected by the cumulative disease duration. Subjective deviation (-8.00 vs. -11.00, P = 0.049) and the amplitude of fusional divergence (6.52 ± 4.10 vs. 4.80 ± 2.59, P = 0.032) were also significantly different between the SS and SF groups. Postoperative breakpoints of fusional divergence and convergence, as well as the amplitude, were distinct between the SS and SF groups. Duration of deviation, angle of deviation, and subjective deviation were independent factors for (SS). Subjective deviation exhibited a predictive index for (SS) and may also reflect the severity of strabismus.
Abstract Background The prevalence of microvascular complications in type 2 diabetes mellitus (T2DM) is increasing. The effect of lipid profiles on diabetic microvascular complications remains debated. This research aimed to study the correlation between lipid profiles and microvascular complications. Methods This retrospective cross-sectional study included 1096 T2DM patients. The patients were divided into the control, diabetic retinopathy (DR), nephropathy (DKD), and peripheral neuropathy (DPN) groups based on the existence of corresponding complications. The lipid profiles were analyzed, and the effect on complications was assessed by logistic regression. Results Compared with the control group, the diabetic microvascular complications group had a higher dyslipidemia rate. The rate of high TGs increased significantly with an increasing number of complications. High TG levels contributed to the risk of DKD, DR, and DPN [odds ratios (ORs): 2.447, 2.267, 2.252; 95% confidence interval: 1.648–3.633, 1.406–3.655, 1.472–3.445]. In the age (years) > 55, T2DM duration (years) > 10, and HbA1c (%) ≥ 7 groups, the risk of high TGs was higher for DKD (ORs: 2.193, 2.419, 2.082), DR (ORs: 2.069, 2.317, 1.993), and DPN (ORs: 1.811, 1.405, 1.427). Conclusion High TG levels increase the risk of diabetic microvascular complications, and patients with older age, longer T2DM duration, and higher HbA1c levels are recommended to keep lipid levels more strictly.
Abstract The noise in a sector or quadrupele mass spectrometer is determined by the source, i.e. the number of ions present in the signal, whereas in Fourier‐transform ion cyclotron resonance it is detector limited. In addition, the Fourier transform spreads white noise equally over the whole spectrum. Thus the accuracy for broad‐band spectra is generally rather low. However, the precision, i.e. the reproducibility of successive spectra, is astonishingly high. This fact has been used with much success, for example in collisionally activated dissociation in Hadamard spectra. It is shown that photofragmentation spectra are also very reproducible and thus allow—at least in principle—a ‘kinetic deconvolution’ of a series of such spectra. In such a case, nonlinear regression has to be applied to the data. Since in most kinetics problems several exponential functions are involved, and since it is well known that these exponential functions are notoriously difficult to approximate with a Marquardt‐Levenberg algorithm, the validity of the results may be questionable. Three examples (protonated benzene, cycloheptatriene, deuterated toluene) are chosen to demonstrate some of the difficulties and pitfalls of the procedure.
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To develop and set up a new culture system, which can apply pressure to cultured cells with open cycling air. The effects of this new system on the pH value, HCO(3)(-) concentration, O(2) pressure (pO(2)), CO2 pressure (pCO(2)) and the proliferation of retinal pigment epithelium (RPE) were tested to evaluate its efficiency in the study of glaucoma.In the open cycling air pressure control culture system, the pressure inside the culture flasks was controlled by increase or decrease of the perfuse airflow. The influence of different culture systems (normal pressure culture system, open cycling air pressure control system and occlusive pressure control system) on the pH value, HCO(3)(-) concentration, pO(2), pCO(2) and proliferation of RPE were tested. The data were analyzed with SPSS software.The open cycling air pressure control culture system worked effectively, the pressure inside the culture flask can be controlled from 0 to 100 mm Hg. The difference of pH value, HCO(3)(-) concentration, pO(2), and pCO(2) of culture medium and the proliferation of RPE between normal pressure culture system and open cycling air pressure control system were not significant (P = 0.927, 0.887, 0.818, 0.770, 0.719, respectively). There was significant difference in these data between normal pressure culture system and occlusive pressure control system (P = 0.001, 0.000, 0.000, 0.000, 0.000, respectively).A new designed standard culture system applying pressure to cells with open cycling air was effective at pressure controlling and pH value, HCO(3)(-) concentration, pO(2) and pCO(2) controlling. This system may act as an ideal model in the experimental study of glaucoma.
Background There is no large population-based study of the distribution and changing trend of strabismus surgeries in China. This study aimed to investigate the distribution and the changing trend of strabismus surgery in a tertiary hospital of China. Methods A retrospective study of all the strabismus surgeries performed in Beijing Tongren Eye Center from 2003 to 2012 was carried out. Characteristics analyzed included the type of strabismus, age, and gender. Results Totally 26 524 strabismus surgeries were performed in Tongren Eye Center during the 10-year period. The number of surgeries increased steadily from 1 507 in 2003 to 3 482 in 2008 and slightly decreased to 3 124 in 2009, but there was a sharp drop to 2 569 in 2010 and then kept relatively steady at 2 760 in 2011 and 2 463 in 2012. Intermittent exotropia (30.3%) was the most common among all kinds of strabismus. The number of strabismus surgeries performed on children under 12 years of age (43.60%) was significantly higher than those of the other age groups ( P <0.05). Unilateral superior oblique paralysis was the most common subtype of paralytic strabismus (8.64%). Conclusions The type distribution of strabismus surgery has changed during the recent decade. The age and type distribution of different strabismus remained basically constant, among which intermittent exotropia was the most common.
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