Jacques De Graef

Centre Hospitalier Universitaire de Saint-Pierre

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M.C. Woussen-Colle

Université Libre de Bruxelles

Marie-Claire Woussen Colle

Morris J. Karnovsky

University of Southern California

G. F. Bahr

Armed Forces Institute of Pathology

Merton Sandler

Universidad de Londres

André Mathias Baptista

Universidade de São Paulo

Walter Chavin

Wayne State University

D Velican

Spitalul Clinic Colentina

Arnold M. Seligman

Johns Hopkins University

Gabriel C. Godman

Columbia University

Cooperative Institutions

Columbia University

Harvard University

Karolinska Institutet

Albert Einstein College of Medicine

United States Department of Veterans Affairs

Johns Hopkins University

National Institutes of Health

University of Pennsylvania

Yale University

University of Milan

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BROMOCRIPTINE AND GASTRIN SECRETION

The Lancet (1978)

Pierre Reding Jacques De Graef P Barbier

10.1016/s0140-6736(78)90990-x

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Citations (6)

Presence of helodermin‐like peptides of the VIP‐secretin family in mammalian salivary glands and saliva

FEBS Letters (1985)

Patrick Robberecht Philippe De Neef André Vandermeers Marie‐Claire Vandermeers‐Piret Michal Svoboda

Helodermin is a biologically active peptide isolated from the venom of the Gila monster lizard ( Heloderma suspectum ) whose structure is related to that of vasoactive intestinal peptide and secretin. Using a specific radioimmunoassay based on antisera prepared by immunizing rabbits with natural helodermin, we demonstrated the presence of helodermin‐like material in mammalian salivary glands, including parotid, submaxillary and sublingual glands from rat and dog, and parotid and submaxillary glands from man. All helodermin‐like materials had an apparent molecular mass of 4–12 kDa. Dog saliva, collected after pilocarpine stimulation, revealed similar immunoreactivity with a major component around 6 kDa.

Secretin

Secretin family

Salivary Proteins

10.1016/0014-5793(85)80445-2

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Citations (24)

Influence of the stimulation state of the parietal cells on the inhibitory effect of omeprazole on gastric acid secretion in dogs

Gastroenterology (1986)

Jacques De Graef M.C. Woussen-Colle

Pentagastrin

Parietal cell

Cimetidine

10.1016/0016-5085(86)90565-2

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Citations (56)

Third International Congress of Histochemistry and Cytochemistry

Springer eBooks (1968)

Muneaki Abe M. Akamatsu Takaharu Matsumoto Nobuo Ohuchi Tomichi Masuya

Cytochemistry

10.1007/978-1-4899-2791-0_1

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Citations (11)

Effect of feeding on catabolism and activity of exogenous gastrin in dogs.

PubMed (1976)

Marie-Claire Woussen Colle J. M. Limbosch Francis Keuppens Jacques De Graef

The effect of meal upon the catabolism and activity of exogenous gastrin was tested in 4 antrectomized and 4 non antrectomized dogs with Heidenhain pouches. In both antrectomized and non antrectomized dogs infused with exogenous gastrin, the meal decreased the serum gastrin level. This decrease amounted to about 20%, 60 minutes after feeding and the gastrinemia then returned gradually to control levels. In non antrectomized dogs, infusion of a near maximal dose of gastrin increased the acid response to the meal to a level above the maximal histamine acid output. Exogenous gastrin also increased the acid response to a meal in antrectomized dogs. These data indicate: 1) That feeding increases the metabolic clearance rate of exogenous gastrin. This effect could be at least partly related to changes in the intestinal blood flow. 2) That, after feeding, one or several hormones capable of stimulating the acid secretion but unrelated to gastrin are probably released. These hormones could be of major importance in the response of denervated pouches to feeding.

Catabolism

Gastrointestinal hormone

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Les glycoprotéines du mucus gastrique du chien. ii. Etude comparée des glycoprotéines des muqueuses et des secrétions fundiques et antrales

Archives françaises des maladies de l'appareil digestif (1975)

Marie-Claire Woussen Colle C Rasinski Jacques De Graef

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Effect of vagotomy and atropine on plasma somatostatin response to a meal in conscious dogs

Regulatory Peptides (1988)

M.C. Woussen-Colle Christine Lalieu Christian Simoens Jacques De Graef

10.1016/0167-0115(88)90088-2

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Citations (13)

LA PLACE DE L'EXPLORATION FONCTIONNELLE GASTRIQUE, DANS LE CONTROLE POST-OPERATOIRE DES VAGOTOMIES CHIRURGICALES

Journal De Chirurgie (1976)

Jacques De Graef

Better knowledge of the physiology of gastric acid secretion and especially of the effects of insulin on secretion permits better definition of the indications for gastric functional investigation after vagotomy. The most reliable estimation of the effects of vagotomy is obtained by determining (before and after) the basal acid secretion, maximal, and post-insulinic secretions. The results should be expressed as hourly output and not in relation to arbitrary criteria based on the titratable acid of the gastric juice. This investigation may be used to determine the quality of vagotomies carried out on a group of patients and to compare series of subjects in which different types of vagotomy were carried out. The tests at present available do not, however, determine precisely the effects of vagotomy in a particular patient. Their use for drawing up individual prognosis has not been demonstrated but their value is far from negligible in the diagnosis of recurrence.

Basal (medicine)

Titratable acid

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Immunoreactive helodermin-like peptides in rat: A new class of mammalian neuropeptides related to secretin and VIP

Biochemical and Biophysical Research Communications (1985)

Patrick Robberecht Jacques De Graef Marie-Claire Woussen Marie‐Claire Vandermeers‐Piret André Vandermeers

Bovine serum albumin

Gel permeation chromatography

Secretin

10.1016/0006-291x(85)90422-x