Danila Capoccia

Sapienza University of Rome

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Frida Leonetti

Sapienza University of Rome

Maria Gisella Cavallo

Sapienza University of Rome

Ilaria Barchetta

Sapienza University of Rome

Laura Bertoccini

Sapienza University of Rome

Marco Giorgio Baroni

University of L'Aquila

Gianfranço Silecchia

Sapienza University of Rome

Flavia Agata Cimini

Sapienza University of Rome

Claudio Di Cristofano

Sapienza University of Rome

Caterina Chiappetta

Policlinico Umberto I

Valentina Ceccarelli

Sapienza University of Rome

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Sapienza University of Rome

Policlinico Umberto I

Università Campus Bio-Medico

Istituto Pasteur

Creative Research Enterprises (United States)

Istituti di Ricovero e Cura a Carattere Scientifico

University of Cagliari

University of Pisa

Università Cattolica del Sacro Cuore

Ospedale Santa Maria Goretti

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Association ofFTOPolymorphisms with Early Age of Obesity in Obese Italian Subjects

Experimental Diabetes Research (2012)

Federica Sentinelli Michela Incani Federica Coccia Danila Capoccia Valentina M. Cambuli

Obesity is recognized as a major health problem worldwide. Genetic factors play a major role in obesity, and genomewide association studies have provided evidence that several common variants within the fat mass- and obesity-associated ( FTO ) gene are significantly associated with obesity. Very limited data is available on FTO in the Italian population. Aims of our study are to investigate: (1) the association of FTO gene SNPs rs9939609 and rs9930506 with body mass index (BMI) and obesity-related parameters in a large cohort (n=752) of Italian obese subjects; (2) the association between the two FTO SNPs and age of onset of obesity. Our results demonstrate a strong association between FTO SNPs rs9939609 (P<0.043) and rs9930506 (P<0.029) with BMI in the Italian population. FTO rs9930506 was significantly associated with higher BMI in a G allele dose-dependent manner (BMI+1.4 kg/m 2 per G allele). We also observed that the association with BMI of the two FTO variants varied with age, with the carriers of the risk alleles developing an increase in body weight earlier in life. In conclusion, our study further demonstrates a role of the genetic variability in FTO on BMI in a large Italian population.

FTO gene

Genome-wide Association Study

Genetic Association

Minor allele frequency

10.1155/2012/872176

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Citations (43)