Yoshihide Takaki

Nagasaki University

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Issei Nishimori

Radiation Effects Research Foundation

Masao Kishikawa

Osaka Dental University

Ichiro Sekine

Sendai Kousei Hospital

Kazuko Matsuo

Nagasaki University

Koretsune FUJINO

Nagasaki University

Masayori Ozaki

Nagasaki University

Minoru Honda

Kyoto University

Hideo Namiki

Queen's Medical Center

Masahiro Ito

Fujita Health University Hospital

Masao Kishikawa

Cooperative Institutions

Nagasaki University

Nagasaki Medical Center

The University of Tokyo

Kyoto University

Nagasaki University Hospital

Sendai Kousei Hospital

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital

Osaka Medical and Pharmaceutical University

Fujita Health University Hospital

Fujita Health University

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Experimental Hypertension Inducesed by Long-Term Psychogenic Stress and Vascular Changes in Rats

The Journal of Japan Atherosclerosis Society (1983)

Ichiro Sekine Masao Kishikawa Yoshihide Takaki Kazuhiro Shimizu Kazuko Matsuo

Male Wistar rats weighing 280g were subjected to the stress condition in which the rats were thrusted unceasingly and harassingly with a bamboo stick by the reseacher, for twenty minutes a day for a period of three and twelve months. The blood pressure reached a high mean value (191±3 S. E.) in twelve months. Mean organweight to body-weight ratios of heart, kidney and adrenal gland when compared to nonstressed controls were increased, and that of thymus was decreased. One of the animals subjected to the stress developed significant vascular pathology in the form of panarteritis like arteriopathy and simple fibrous intimal thickening, and others disclosed nothing of vascular changes. The analysis of relative thickness of media to radius in the branches of coronary arteries resulted in no change between subjected rats and controls in thickness of media, compared to that of spontaneously hypertensive reats (SHR) which disclosed medial hypertrophy.

Compensatory hypertrophy

10.5551/jat1973.11.1_159

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Multiple Myeloma of Atomic Bomb Survivors -Autopsy Cases in the Nagasaki District (1946-1980)-

Acta medica Nagasakiensia (1985)

Masao Kishikawa Yoshihide Takaki Mika Ikeyama Masachika Iseki Hisayoshi Kondo

TitleMultiple Myeloma of Atomic Bomb Survivors -Autopsy Cases in theNagasaki District (1946-1980)-Author(s)Kishikawa, Masao; Takaki, Yoshihide; Ikeyama, Mika; Iseki, Masachika;Kondo, Hisayoshi; Nishimori, IsseiCitation Acta medica Nagasakiensia. 1985, 30(1-3), p.249-255Issue Date 1985-10-25URL http://hdl.handle.net/10069/15683Right

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PRIMARY MALIGNANT FIBROUS HISTIOCYTOMA OF THE ENDOMETRIUM

Acta Pathologica Japonica (1983)

Yoshihide Takaki Masao Kishikawa Ichiro Serine Issei Nishimori Mitsuro Hieata

Malignant fibrous histiocytoma (MFH) has become one of the most common malignancies occurring in soft tissue. To our knowledge, the present case is the first of MFH occurring in the endometrium. The uterus removed from a 47‐year‐old woman demonstrated a large multinodular endometrial lesion with gross invasive foci in the myometrium and the left oviduct. Microscopically, the endometrial tumor and the invasive lesions were composed of dense sheets of markedly pleomorphic cells consisting of fibroblast‐like cells, histiocyte‐like cells, foamy histiocytes, benign appearing multinucleated giant cells resembling either osteoclasts or Touton giant cells, and bizarre tumor giant cells. Some of the tumor cells showed phagocytic activities. The tumor cells were oriented in a random or haphazard fashion and classical storiform and fascicular patterns were not observed. The tumor was diagnosed as MFH consisting exclusively of so‐called pleomorphic pattern. The patient is alive without evidence of disease, months following total hysterectomy and bilateral salpingo‐oophorectomy.

Primary (astronomy)

10.1111/j.1440-1827.1983.tb02130.x

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Effects of Dilazep on Hypertensive Nephropathy in the Spontaneously Hypertensive Rat (SHR) and Stroke Prone SHR (SHRSP)

Japanese Heart Journal (1984)

Yoshihide Takaki Ichiro Sekine Kazuko Matsuo Junichi Miyazaki Issei Nishimori

Hypertensive Nephropathy

Stroke

Spontaneously hypertensive rat

10.1536/ihj.25.872

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Immunological Studies on Renal Vasotoxic Substance

The Journal of Japan Atherosclerosis Society (1982)

Yoshiaki Yushita Yoshihide Takaki Masao Kishikawa Issei Nishimori

We have reported that the renal vasotoxic substance is included in the microsomal fraction of renal cortical extracts, and that the fraction has no-pressor effect.In this experiment, Ouchterlony method and immuno-electrophoretic analysis are used in order to identify the renal vasotoxic substance in serum immunologically. Antigen-antibody reactions are performed using the rat serum which is treated with transient renal ischemia, and using anti-rat renal microsomal fraction rabbit serum. Ouchterlony method points out specific antigen antibody reaction lines clearly. Immuno-electrophoretic analysis also points out five bands corresponding with α1, α2, β, γ-globulin levels.This results suggest a possibility that the injured kidney releases the renal vasotoxic substance which results in various vascular lesions.

Ouchterlony double immunodiffusion

Immunodiffusion

10.5551/jat1973.10.1_53

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Malignant Lymphoma of the Brain Associated with Multiple Sclerosis-Like Manifestations

Acta Medica Nagasakiensia (1986)

Masao Kishikawa Yoshihide Takaki Minoru Honda Masachika Iseki Issei Nishimori

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Cardiovascular Pathology in Spontaneously Hypertensive Rats Chronically Exposed to Combined Restraint and Electric Stimulation

Japanese Heart Journal (1984)

Ichiro Sekine Masahiro Ito Minoru Honda Yoshihide Takaki Kazuko Matsuo

10.1536/ihj.25.894

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