David R. Head

Vanderbilt University Medical Center

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Cheryl L. Willman

University of New Mexico

Frederick R. Appelbaum

University of Washington

Keith Shults

Incell Corporation (United States)

Leanne A. Flye

Covance (United States)

Kenneth J. Kopecky

Fred Hutch Cancer Center

Robert C. Briggs

Virginia Tech

Greg Stelzer

Fluidigm (United States)

Susana C. Raimondi

St. Jude Children's Research Hospital

Sara A. McClintock-Treep

Vanderbilt University Medical Center

Madan Jagasia

Vanderbilt University

Cooperative Institutions

St. Jude Children's Research Hospital

109

University of Tennessee Health Science Center

Vanderbilt University Medical Center

Vanderbilt University

University of Tennessee at Knoxville

Memorial Sloan Kettering Cancer Center

SWOG Cancer Research Network

The University of Texas MD Anderson Cancer Center

National Institutes of Health

City Of Hope National Medical Center

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Supplementary Figure 1 from Dysregulated Human Myeloid Nuclear Differentiation Antigen Expression in Myelodysplastic Syndromes: Evidence for a Role in Apoptosis

Robert C. Briggs Keith Shults Leanne A. Flye Sara A. McClintock-Treep Madan Jagasia

Supplementary Figure 1 from Dysregulated Human Myeloid Nuclear Differentiation Antigen Expression in Myelodysplastic Syndromes: Evidence for a Role in Apoptosis

Expression (computer science)

10.1158/0008-5472.22366503

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Citations (0)

Reproducibility of the French‐American‐British classification of acute Leukemia: The southwest oncology group experience

American Journal of Hematology (1985)

David R. Head Richard A. Savage Lizardo Cerezo Catherine Craven John N. Bickers

Abstract After initial French‐American‐British (FAB) diagnosis by a multiinstitutional Southwest Oncology Group panel, slides of acute leukemia cases were recirculated to panel members for second review. The reproducibility of the FAB classification is analyzed. The classification is reproducible in the 70% range in panel reviewer hands and allows remarkable reproducibility in the morphologic and cytochemical distinction of acute lymphoid leukemia (ALL) from acute myeloid leukemia (AML). The limitations of a morphologic and cytochemical classification of acute leukemia are discussed. A simplification of the FAB system, merging M1, M2, and M4 as M7, is proposed; this simplification improves the system's reproducibility.

10.1002/ajh.2830180108

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Citations (42)

A Double-Blind Placebo-Controlled Trial of Granulocyte Colony-Stimulating Factor in Elderly Patients With Previously Untreated Acute Myeloid Leukemia: A Southwest Oncology Group Study (9031)

Blood (1998)

John E. Godwin Kenneth J. Kopecky David R. Head Cheryl L. Willman Catherine P. Leith

Regimen

Daunorubicin

10.1182/blood.v91.10.3607

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Citations (312)

Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17)

Blood (1995)

Jonathan D. Licht Christine Chomienne André Goy Alex Chen Amy A. Scott

Tretinoin

10.1182/blood.v85.4.1083.bloodjournal8541083

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Citations (354)

Mutational Burden in Acute Myeloid Leukemia Is Largely Age Dependent

Blood (2015)

Aaron C. Shaver Adam C. Seegmiller Stephen A. Strickland Robert Daber Sanjay Mohan

NPM1

10.1182/blood.v126.23.2605.2605

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Citations (1)

Hematologic Abnormalities and Acute Myeloid Leukemia in Children and Adolescents Administered Intensified Chemotherapy for the Ewing Sarcoma Family of Tumors

The American journal of pediatric hematology/oncology (2000)

Howard Lin Catherine A. Poquette Neyssa Marina David R. Head Alvida M. Cain

Current treatment of the Ewing sarcoma family of tumors (ESFT) includes intensive multiagent chemotherapy with topoisomerase II inhibitors, alkylating agents, and granulocyte colony-stimulating factor (G-CSF). This treatment approach has been associated with myelodysplasia and acute myeloid leukemia. Because macrocytosis and thrombocytopenia are distinctive features of myelodysplasia, the authors evaluated a cohort of patients treated for ESFT to determine the degree and duration of macrocytosis and thrombocytopenia and their relation with the development of therapy-related hematologic malignancies.The study group consisted of 73 patients with ESFT treated on two consecutive protocols (EW92 and EW87). Both chemotherapy regimens incorporated the same agents but differed in cumulative drug dose, dose per course, and the use of G-CSF. Platelet counts and the mean corpuscular volume (MCV) of erythrocytes were determined at diagnosis and during follow-up visits after completion of treatment.Patients in the EW92 group had significantly greater MCVs after treatment than did the less intensively treated EW87 group. These changes persisted throughout the 40-month observation period. Patients in the EW92 group also had lesser mean platelet counts after treatment than those in the EW87 group. MCV differences (from baseline) were inversely related to platelet counts. The cumulative incidence of treatment-related acute myeloid leukemia was 7.8%+/-4.7% at 4 years in the EW92 group and zero in the EW87 group.Patients treated for ESFT with intensive chemotherapy that includes large doses of alkylators, topoisomerase II inhibitors, and G-CSF characteristically have persistently elevated MCVs and decreased platelet counts after completion of therapy. These hematologic abnormalities may represent stem cell damage, predisposing patients to myelodysplasia and acute myeloid leukemia, but further study is needed to establish this relation.

Cumulative incidence

Macrocytosis

Cumulative dose

Platelet Transfusion

10.1097/00043426-200007000-00008

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Citations (47)

Refractory Anemia With Ringed Sideroblasts in Children

Journal of Pediatric Hematology/Oncology (1999)

Gcf Chan David R. Head Winfred C. Wang

Three pediatric patients with refractory anemia with ringed sideroblasts (RARS) are presented. Bone marrow aspirates were examined using Romanowsky and Prussian blue iron stains in all three patients, and electron microscopic analysis was performed in one patient. All three patients had cytogenetic analysis of the bone marrow. Other studies included analysis of serum iron, total iron-binding capacity, ferritin, copper, vitamins B6 and B12, and folate levels. Antibody titers to Parvovirus, HIV, and other viruses were measured. The patients had contrasting clinical courses. Patients 1 and 2 had dysplastic hematopoietic features and cytogenetic findings (with either partial or one allele loss of chromosome 7), suggestive of my-elodysplastic syndrome. Patient 1 experienced acute myeloid leukemia (AML) and had a good response to AML-directed therapy. Patient 2 had prolonged cytopenias and underwent bone marrow transplantation (BMT). Patient 3 had features suggestive of refractory anemia associated with mitochondrial cytopathy, including normal cytogenetics with pronounced vacuolization of marrow precursors. His anemia regressed spontaneously a few months after diagnosis. These patients represent two subgroups of pediatric RARS. Patients with the myelodysplastic syndrome (MDS) type may progress to cytopenias or leukemia and may require aggressive therapy; the type is characterized by clonal cytogenetic findings. The non-MDS type, which may relate to mitochondrial cytopathy, often shows spontaneous regression and requires only supportive treatment; it has normal cytogenetic findings.

Sideroblastic anemia

10.1097/00043426-199909000-00015

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Citations (4)

A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases

Leukemia (2003)

Henrik Hasle Charlotte M. Niemeyer J M Chessells Irith Baumann John M. Bennett

Chronic myelomonocytic leukemia

Juvenile myelomonocytic leukemia

Cytopenia

10.1038/sj.leu.2402765

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Citations (430)

Human herpesvirus-8 (HHV-8) associated with small non-cleaved cell lymphoma in a child with AIDS

American Journal of Hematology (1999)

Charles T. Leach Christopher Frantz David R. Head Shou‐Jiang Gao Kenneth L. McClain

The association of human herpesvirus-8 (HHV-8) with a small non-cleaved cell lymphoma is described in a child with the acquired immunodeficiency syndrome (AIDS) who developed a malignant pleural effusion and radiologic evidence of multiple solid tumors. HHV-8 DNA and Epstein-Barr virus DNA were identified in pleural fluid cells by polymerase chain reaction (PCR) amplification. The serum antibody titer against lytic HHV-8 proteins was 1:640; antibodies to latent HHV-8 proteins were not detected. Cytogenetic analysis of malignant cells revealed three abnormal karyotypes sharing the common finding of a t(8;14) translocation. Rearrangement of c-myc was demonstrated by PCR analysis. Oligoclonal JH immunoglobulin bands were found. Insufficient pleural fluid cells were available to permit localization of HHV-8 to malignant cells by in situ hybridization. This malignancy contrasts with HHV-8-associated lymphomas reported in adult patients with AIDS with respect to cell morphology, c-myc translocation, and oligoclonal immunoglobulin gene rearrangement. HHV-8 is associated with a wider spectrum of malignancies than recognized previously.

Primary effusion lymphoma

Gene rearrangement

Human herpesvirus 6

Lytic cycle

10.1002/(sici)1096-8652(199903)60:3<215::aid-ajh8>3.0.co;2-f

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Citations (13)

Childhood acute lymphoblastic leukemia with equivocal chromosome markers of the t(I;I9) translocation

Genes Chromosomes and Cancer (1995)

Leonid V. Filatov Frederick G. Behm Ching‐Hon Pui David R. Head James R. Downing

The t(1;19)(q23;p13) or its derivative encodes an E2A-PBXI fusion transcript and protein that has been shown to have important prognostic and therapeutic implications in patients with acute lymphoblastic leukemia (ALL). We describe two childhood cases in which a der(22)t(1;22)(q21-23;p13) cytogenetically mimicked a der(19)t(1;19)(q23;p13). In one case, which was phenotyped as early pre-B ALL with hyperdiploidy but lacked evidence of an E2A-PBX1 gene fusion by molecular study, the poor banding quality of chromosomes led to misinterpretation of the cytogenetic findings; a correct diagnosis was established only after analysis by the fluorescence in situ hybridization (FISH) method. The second case, which was classified as pseudodiploid pre-B ALL, had both a derivative 19 and a derivative 22 but lacked sufficient cells for evaluation of E2A-PBX1 gene fusion. This case was included in order to compare the der(19)t(1;19) and the der(22)t(1;22) and to pinpoint the difficulty in distinguishing these markers. FISH analysis can resolve diagnostic uncertainty in cases of ALL with equivocal chromosome 19 markers.

Derivative chromosome

Breakpoint

10.1002/gcc.2870130205

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Citations (12)